scholarly journals A Systematic Review on Parasite Induced Carcinogenesis

2020 ◽  
Vol 5 (6) ◽  
pp. 1095-1099
Author(s):  
Avinaba Mukherjee
Keyword(s):  
Systematic Review ◽  
Life Cycle ◽  
Immune Evasion ◽  
Parasitic Infection ◽  
Cross Infection ◽  
The Other ◽  
Drug Designing ◽  
Evasion Strategy ◽  
Parasitic Pathogens ◽  
Cell Malignancy

Parasitic pathogens through cross infection exert carcinogenesis in human body. The immune evasion strategy that has been adapted by several parasites is recognized to be associated with human carcinogenicity. In this review, studies have been analyzed which depicts how carcinogenicity occurs through several parasitic infection. Among the parasites that are involved toward developing carcinogenicity, Helminth is found to be dominant as per the recent studies. One reason for this that they mostly have prolonged life cycle than the other parasites, therefore more complex network through molecular endeavour has been adapted by them that would leads the host cell malignancy. This review particularly summarizes the parasites that are involved in carcinogenicity and the mechanism that they adapt to develop so. Targeting the molecules that are being modulated by parasites to trigger carcinogenesis, drug development can be done. Drug designing can also be made by targeting the parasite induced secretory molecules which mainly cross talk to develop carcinogenicity. Specially conjugated therapy of parasitic drugs with anticancer drugs that are target specific should be used at minimum doses so that to block the parasite induced carcinogenicity in host body.

scholarly journals Are electric vehicles eco-friendly products? A review from life cycle and sustainability perspective

2021 ◽  
Vol 343 ◽  
pp. 07002
Author(s):  
Niculina Alexandra Grigore ◽  
Claudiu Vasile Kifor
Keyword(s):  
Systematic Review ◽  
Life Cycle ◽  
Environmental Impact ◽  
Electric Vehicle ◽  
Electric Vehicles ◽  
Automotive Industry ◽  
Point Of View ◽  
The Other ◽  
Internal Factors ◽  
Use Phase

Industry, especially the automotive industry is permanently changing and adapting to the external and internal factors. The appearance of the new types of vehicles – electric vehicles, is a big and important step not only regarding the evolution of the product, but also regarding the advantages of reducing environmental impact. It is promoted the idea that an electric vehicle generates less direct emissions in use phase compared with a conventional one. If we limit to this, we could say that we are dealing with an eco-friendly type of vehicle. The question is, can we extend this idea to the other stages of the life cycle? What about the sustainability of the industry? This article highlights the methods of environmental impact assessment used by researchers for electric vehicles in terms of life cycle and sustainability. The findings of this systematic review demonstrate that even if are a large number of articles addressing electric vehicles, only a small number of them evaluate the electric vehicle from life cycle and sustainability point of view.

A Systematic Review and Catalog of Security Metric during the Secure Software Development Life Cycle

2020 ◽  
Vol 13 ◽  
Author(s):  
Sampada G.C ◽  
Tende Ivo Sake ◽  
Amrita
Keyword(s):  
Systematic Review ◽  
Life Cycle ◽  
Software Development ◽  
Software Security ◽  
Security Assessment ◽  
Security Metrics ◽  
Development Life Cycle ◽  
Development Processes ◽  
Secure Software Development ◽  
Software Development Life Cycle

Background: With the advancement in the field of software development, software poses threats and risks to customers’ data and privacy. Most of these threats are persistent because security is mostly considered as a feature or a non-functional requirement, not taken into account during the software development life cycle (SDLC). Introduction: In order to evaluate the security performance of a software system, it is necessary to integrate the security metrics during the SDLC. The appropriate security metrics adopted for each phase of SDLC aids in defining the security goals and objectives of the software as well as quantify the security in the software. Methods: This paper presents systematic review and catalog of security metrics that can be adopted during the distinguishable phases of SDLC, security metrics for vulnerability and risk assessment reported in the literature for secure development of software. The practices of these metrics enable software security experts to improve the security characteristics of the software being developed. The critical analysis of security metrics of each phase and their comparison are also discussed. Results: Security metrics obtained during the development processes help to improve the confidentiality, integrity, and availability of software. Hence, it is imperative to consider security during the development of the software, which can be done with the use of software security metrics. Conclusion: This paper reviews the various security metrics that are meditated in the copious phases during the progression of the SDLC in order to provide researchers and practitioners with substantial knowledge for adaptation and further security assessment.

scholarly journals Machine Learning in Medical Emergencies: a Systematic Review and Analysis

2021 ◽  
Vol 45 (10) ◽  
Author(s):  
Inés Robles Mendo ◽  
Gonçalo Marques ◽  
Isabel de la Torre Díez ◽  
Miguel López-Coronado ◽  
Francisco Martín-Rodríguez
Keyword(s):  
Machine Learning ◽  
Systematic Review ◽  
Language Processing ◽  
Emergency Services ◽  
Clinical Decision ◽  
Quality Of Healthcare ◽  
The Other ◽  
Other Hand ◽  
Increasing Demand ◽  
Commercial Applications

AbstractDespite the increasing demand for artificial intelligence research in medicine, the functionalities of his methods in health emergency remain unclear. Therefore, the authors have conducted this systematic review and a global overview study which aims to identify, analyse, and evaluate the research available on different platforms, and its implementations in healthcare emergencies. The methodology applied for the identification and selection of the scientific studies and the different applications consist of two methods. On the one hand, the PRISMA methodology was carried out in Google Scholar, IEEE Xplore, PubMed ScienceDirect, and Scopus. On the other hand, a review of commercial applications found in the best-known commercial platforms (Android and iOS). A total of 20 studies were included in this review. Most of the included studies were of clinical decisions (n = 4, 20%) or medical services or emergency services (n = 4, 20%). Only 2 were focused on m-health (n = 2, 10%). On the other hand, 12 apps were chosen for full testing on different devices. These apps dealt with pre-hospital medical care (n = 3, 25%) or clinical decision support (n = 3, 25%). In total, half of these apps are based on machine learning based on natural language processing. Machine learning is increasingly applicable to healthcare and offers solutions to improve the efficiency and quality of healthcare. With the emergence of mobile health devices and applications that can use data and assess a patient's real-time health, machine learning is a growing trend in the healthcare industry.

scholarly journals Life Cycle GHG Emissions of Residential Buildings in Humid Subtropical and Tropical Climates: Systematic Review and Analysis

Buildings ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 6
Author(s):  
Daniel Satola ◽  
Martin Röck ◽  
Aoife Houlihan-Wiberg ◽  
Arild Gustavsen
Keyword(s):  
Systematic Review ◽  
Life Cycle ◽  
Residential Buildings ◽  
Construction Materials ◽  
Ghg Emissions ◽  
Energy Performance ◽  
Cycle Performance ◽  
Tropical Climates ◽  
Building Life Cycle ◽  
Total Life

Improving the environmental life cycle performance of buildings by focusing on the reduction of greenhouse gas (GHG) emissions along the building life cycle is considered a crucial step in achieving global climate targets. This paper provides a systematic review and analysis of 75 residential case studies in humid subtropical and tropical climates. The study investigates GHG emissions across the building life cycle, i.e., it analyses both embodied and operational GHG emissions. Furthermore, the influence of various parameters, such as building location, typology, construction materials and energy performance, as well as methodological aspects are investigated. Through comparative analysis, the study identifies promising design strategies for reducing life cycle-related GHG emissions of buildings operating in subtropical and tropical climate zones. The results show that life cycle GHG emissions in the analysed studies are mostly dominated by operational emissions and are the highest for energy-intensive multi-family buildings. Buildings following low or net-zero energy performance targets show potential reductions of 50–80% for total life cycle GHG emissions, compared to buildings with conventional energy performance. Implementation of on-site photovoltaic (PV) systems provides the highest reduction potential for both operational and total life cycle GHG emissions, with potential reductions of 92% to 100% and 48% to 66%, respectively. Strategies related to increased use of timber and other bio-based materials present the highest potential for reduction of embodied GHG emissions, with reductions of 9% to 73%.

scholarly journals Gasperini Syndrome: A Case Report and Systematic Review and Proposing a New Definition

2020 ◽  
Vol 12 (3) ◽  
pp. 433-439
Author(s):  
Riwaj Bhagat ◽  
Siddharth Narayanan ◽  
Marwa Elnazeir ◽  
Thong Diep Pham ◽  
Robert Paul Friedland ◽  
...  
Keyword(s):  
Systematic Review ◽  
Brain Mri ◽  
Cranial Nerves ◽  
Clinical Manifestations ◽  
The Other ◽  
Neurological Deficits ◽  
Brainstem Stroke ◽  
Neurological Features ◽  
The Right ◽  
Core Features

Gasperini syndrome (GS), a rare brainstem syndrome, is featured by ipsilateral cranial nerves (CN) V–VIII dysfunction with contralateral hemibody hypoesthesia. While there have been 18 reported cases, the GS definition remains ambiguous. We report a new case and reviewed the clinical features of this syndrome from all published reports to propose a new definition. A 57-year-old man with acute brainstem stroke had right CN V–VIII and XII palsies, left body hypoesthesia and ataxia. Brain MRI showed an acute stroke in the right caudal pons and bilateral cerebellum. After a systematic review, we classified the clinical manifestations into core and associate features based on the frequencies of occurring neurological deficits. We propose that a definitive GS requires the presence of ipsilateral CN VI and VII palsies, plus one or more of the other three core features (ipsilateral CN V, VIII palsies and contralateral hemibody hemihypalgesia). Additionally, GS, similar to Wallenberg’s syndrome, represents a spectrum that can have other associated neurological features. The revised definition presented in this study may enlighten physicians with the immediate recognition of the syndrome and help improve clinical localization of the lesions and its management.

scholarly journals Unusual sites of bone involvement in Langerhans cell histiocytosis: a systematic review of the literature

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Nahid Reisi ◽  
Pouran Raeissi ◽  
Touraj Harati Khalilabad ◽  
Alireza Moafi
Keyword(s):  
Systematic Review ◽  
Dendritic Cells ◽  
Rare Disease ◽  
Langerhans Cell Histiocytosis ◽  
Case Reports ◽  
Langerhans Cell ◽  
The Other ◽  
Bone Involvement ◽  
Intracranial Extension ◽  
Pathologic Fractures

Abstract Background Langerhans cell histiocytosis (LCH) is a rare disease that originates from the uncontrolled proliferation and accumulation of bone marrow-derived immature myeloid dendritic cells. Dendritic cells are a type of histiocyte that play an important role in the human immune system and are found in the bone, skin, stomach, eyes, intestines, and lungs. Objective This systematic review aimed to collect and report published case reports of rare bone disease caused by LCH to avoid misdiagnoses or delays in diagnosis. Methods We systematically searched Scopus, PubMed, Embase, and Web of Sciences from August 1, 2000 to December 31, 2019. Studies reporting cases of LCH with rare bone involvement were included. Results We identified 60 articles including 64 cases. Of the identified cases, 31 (48.4%) involved children, and 33 (51.6%) involved adults. Additionally, 46.9% (30 individuals) were from Asian countries. The mean age of the children was 7.6 ± 4.3 years and that of the adults was 36 ± 12 years. The findings indicated that unifocal bone involvements were the most prevalent form of the disease (68.7%), and, overall, the skull and chest wall were the most commonly affected bones in both adults and children. The spine and long bones were the second most commonly affected bones in children, and the spine and jaw were the second most commonly affected bones in adults. Pain and swelling were the most frequent presenting signs among the investigated cases, and loss of consciousness, myelopathy, nerve palsy, visual loss, torticollis and clicking sounds were rare signs. Osteolytic lesions were the most frequent radiologic feature (62.5%), and intracranial hemorrhage, fluid–fluid level, dura and intracranial extension and pathologic fractures were rare radiological features. Total excision, curettage and observation in the unifocal group of patients and systemic chemotherapy in the other groups (i.e., multifocal and multisystem) were the most frequent management approaches. The recovery rates of the unifocal and multifocal groups were 77.3% and 81.8%, respectively, while that of the multisystem group was 55.5%. The rates of recurrence and mortality in the multisystem group were 11% and were higher than those in the other groups. Conclusions LCH is a rare disease that can affect any organ in the human body. However, bone is the most commonly involved organ, and rare bone involvements may be the first or only symptom of the disease due to the rarity of such lesions; a lack of familiarity with them may result in misdiagnosis or delayed diagnosis.

scholarly journals More Than Two Decades of Research on Selective Traditions in Environmental and Sustainability Education—Seven Functions of the Concept

2021 ◽  
Vol 13 (12) ◽  
pp. 6524
Author(s):  
Per J. Sund ◽  
Niklas Gericke
Keyword(s):  
Systematic Review ◽  
Teacher Education ◽  
Sustainability Education ◽  
Qualitative Studies ◽  
The Other ◽  
Research Practice ◽  
Selective Tradition ◽  
Qualitative Systematic Review ◽  
Selective Traditions

This study investigates functions of the concept of selective traditions by means of a qualitative systematic review synthesis of earlier research. The study is based on a review method for integrating qualitative studies and looks for “themes” in or across them. In this case, it is about how the identified publications (twenty-four in total) use the concept of selective traditions. All but two studies stem from the Swedish context. The selective traditions relate to teachers’ approaches to the content, methods and purposes of environmental and sustainability education (ESE). Teachers mainly work within one specific selective tradition. Seven different functions were found in the publications of which five are claimed to be valuable for the development of ESE teaching, while the other two functions are useful in monitoring changes and development in ESE teaching. The results are discussed in terms of the consequences for research, practice and teacher education aiming at offering suggestions on how to develop future (transformative) ESE teaching.

scholarly journals The laboratory findings and different COVID-19 severities: a systematic review and meta-analysis

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Erfan Kazemi ◽  
Reihane Soldoozi Nejat ◽  
Fatemeh Ashkan ◽  
Hossein Sheibani
Keyword(s):  
Systematic Review ◽  
Platelet Count ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Lymphocyte Count ◽  
Leukocyte Count ◽  
Mean Value ◽  
The Other ◽  
Invasive Ventilation ◽  
Laboratory Findings

Abstract Background Abnormal laboratory findings are common in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of this systematic review was to investigate the effect of the level of some laboratory factors (C-reactive protein (CRP), creatinine, leukocyte count, hemoglobin, and platelet count) on the severity and outcome of coronavirus disease 2019 (COVID-19). Methods We searched PubMed, Web of Science, Scopus, and Google Scholar. We collected the articles published before May 26, 2020. We gathered the laboratory factors in groups of patients with COVID-19, and studied the relation between level of these factors with severity and outcome of the disease. Results Mean CRP level, creatinine, hemoglobin, and the leukocytes count in the critically ill patients were significantly higher than those of the other groups (non-critical patients); mean CRP = 54.81 mg/l, mean creatinine = 86.82 μmol/l, mean hemoglobin = 144.05 g/l, and mean leukocyte count = 7.41 × 109. The lymphocyte count was higher in patients with mild/moderate disease (mean: 1.32 × 109) and in the invasive ventilation group (mean value of 0.72 × 109), but it was considerably lower than those of the other two groups. The results showed that the platelet count was higher in critically ill patients (mean value of 205.96 × 109). However, the amount was lower in the invasive ventilation group compared with the other groups (mean level = 185.67 × 109). Conclusion With increasing disease severity, the leukocyte count and the level of CRP increase significantly and the lymphocyte count decreases. There seems to be a significant relation between platelet level, hemoglobin, and creatinine level with severity of the disease. However, more studies are required to confirm this.

The butterfly squid Stoloteuthis leucoptera in the Mediterranean

1991 ◽  
Vol 71 (1) ◽  
pp. 47-51 ◽  
Author(s):  
Lidia Orsi Relini ◽  
Daniela Massi
Keyword(s):  
Life Cycle ◽  
Adult Male ◽  
The Other ◽  
Otter Trawl ◽  
Ligurian Sea ◽  
The Mediterranean ◽  
Unique Species ◽  
Recent Immigration

The presence of Stoloteuthis leucoptera in the Mediterranean is recorded on the basis of three specimens, including an adult male, caught by IKMT and by commercial otter-trawl in the Ligurian Sea. The hypothesis of a recent immigration is discussed.The list of Mediterranean cephalopods (Mangold Wirz, 1963; Torchio, 1968; Bello, 1986; Mangold & Boletzsky, 1987) includes the Sepiolidae of the subfamily Heteroteuthinae, whose members are supposed to be pelagic throughout their life cycle. Mangold Wirz (1963) recognizes in the Mediterranean fauna the unique species Heteroteuthis dispar, the other authors include H. atlantis Voss, which Voss himself (1955) reported at Messina. To this group may now be added Stoloteuthis leucoptera (Verrill, 1878) a species until now recorded in limited Atlantic areas. Verrill (1881) wrote “This species is an exceedingly beautiful one, when living, owing to the elegance and brilliancy of its colours and the gracefulness of its movements. In swimming it moves its fins in a manner analogous to the motion of the wings of a butterfly.”

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