Progress in the Emergency Management of Hereditary Angioedema: Focus on New Treatment Options in the United States

2012 ◽  
Vol 124 (3) ◽  
pp. 91-100 ◽  
Author(s):  
Jonathan A. Bernstein ◽  
Joseph J. Moellman
Keyword(s):  
United States ◽  
Emergency Management ◽  
Hereditary Angioedema ◽  
Treatment Options ◽  
The United States ◽  
New Treatment

scholarly journals 1167. Trends in Multi-Drug-Resistant Gonorrhea, Gonococcal Isolate Surveillance Project, United States, 1987–2016

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S352-S352
Author(s):  
Sancta St. Cyr ◽  
Ellen Kersh ◽  
Hillard Weinstock ◽  
Elizabeth Torrone
Keyword(s):  
United States ◽  
Antimicrobial Susceptibility ◽  
Treatment Options ◽  
The United States ◽  
Drug Resistant ◽  
Appropriate Treatment ◽  
High Prevalence ◽  
Agar Dilution ◽  
Male Patients ◽  
New Treatment

Abstract Background Neisseria gonorrhoeae’s ability to develop resistance to antibiotics used for treatment and a limited development of new therapies have made this organism one of three urgent threat pathogens in the United States. We provide the first report of US trends in multi-drug-resistant (MDR) and extensively-drug-resistant (XDR) gonorrhea. Methods The Gonococcal Isolate Surveillance Project (GISP) monitors trends in antimicrobial susceptibility in N. gonorrhoeae in the United States. Antimicrobial susceptibility testing by agar dilution is performed on urethral isolates from male patients at participating STD clinics. Minimum inhibitory concentration (MIC) are used to identify isolates with resistance or reduced susceptibility using the following criteria: fluoroquinolones (ciprofloxacin [MIC ≥1.0 μg/mL]) and elevated MICs to cephalosporins (cefixime [MIC ≥0.25 μg/mL], ceftriaxone [MIC ≥0.25 μg/mL]) and macrolides (azithromycin [MIC ≥1.0 μg/mL before 2005 and ≥2.0 μg/mL 2005–2016]). In this analysis, MDR is defined as resistance or elevated MICs to ≥2 classes of antimicrobials; XDR as resistance or elevated MICs to ≥3 classes. This classification excludes penicillin and tetracycline due to their long history and high prevalence of gonococcal resistance. Results During 1987–2016, 159,445 isolates were collected through GISP. In 1998, the first MDR strains were identified. Although only 0.04% of isolates that year, these isolates showed elevated MICs to both cephalosporins and macrolides. By 2010, 1.0% of GISP isolates were MDR with elevated MICs or resistance to two of the cephalosporins, macrolides, or fluoroquinolones. In 2011, the proportion of isolates that were MDR peaked at 1.3%. In 2016, after minor fluctuations, 1.1% of GISP isolates were considered MDR. Only one occurrence of XDR, in 2011, has been seen in GISP. The strain was resistant to fluoroquinolones with elevated MICs to both cephalosporins and macrolides. Conclusion MDR and XDR gonorrhea have remained low over the past three decades; however, dual treatment with cephalosporins and macrolides is the last remaining recommended therapy for N. gonorrhoeae. Until new treatment options become available, a combination of surveillance and ensuring appropriate treatment are needed to delay further resistance. Disclosures All authors: No reported disclosures.

Comparative Economics of On-Demand Treatment Options Approved in the United States for Hereditary Angioedema

2013 ◽  
Vol 131 (2) ◽  
pp. AB33 ◽  
Author(s):  
Geetika Sabharwal ◽  
Natalia Vernon ◽  
Art Zbrozek ◽  
Thomas Machnig ◽  
Timothy J. Craig
Keyword(s):  
United States ◽  
Hereditary Angioedema ◽  
Treatment Options ◽  
The United States ◽  
On Demand ◽  
Comparative Economics

scholarly journals Advances in the Management of Sepsis and the Understanding of Key Immunologic Defects

2011 ◽  
Vol 115 (6) ◽  
pp. 1349-1362 ◽  
Author(s):  
Lee P. Skrupky ◽  
Paul W. Kerby ◽  
Richard S. Hotchkiss
Keyword(s):  
United States ◽  
Intensive Care Unit ◽  
Critical Care ◽  
Intensive Care ◽  
Operating Room ◽  
The United States ◽  
Difficult Problem ◽  
Treatment Algorithms ◽  
New Treatment ◽  
Overall Mortality

Anesthesiologists are increasingly confronting the difficult problem of caring for patients with sepsis in the operating room and in the intensive care unit. Sepsis occurs in more than 750,000 patients in the United States annually and is responsible for more than 210,000 deaths. Approximately 40% of all intensive care unit patients have sepsis on admission to the intensive care unit or experience sepsis during their stay in the intensive care unit. There have been significant advances in the understanding of the pathophysiology of the disorder and its treatment. Although deaths attributable to sepsis remain stubbornly high, new treatment algorithms have led to a reduction in overall mortality. Thus, it is important for anesthesiologists and critical care practitioners to be aware of these new therapeutic regimens. The goal of this review is to include practical points on important advances in the treatment of sepsis and provide a vision of future immunotherapeutic approaches.

scholarly journals Emergency Management Missing from the Pandemic?

2020 ◽  
Vol 18 (7) ◽  
pp. 149-150
Author(s):  
Attila J. Hertelendy, PhD ◽  
William L. Waugh, Jr., PhD
Keyword(s):  
United States ◽  
Emergency Management ◽  
Task Force ◽  
Medical Personnel ◽  
The United States ◽  
First Year ◽  
Protective Equipment ◽  
Protective Measures ◽  
White House ◽  
Pandemic Response

The change in presidential administrations in the United States promises new approaches to deal with the COVID-19 pandemic. The first year of the pandemic response in the United States has been characterized by a lack of national leadership. Moreover, the message from the White House Coronavirus Task Force has been muddled at best. There have been great inconsistencies in how the States have chosen to address spreading infections and increased stress on individual Americans who are trying to protect themselves and their families. The same pattern can be found with the distribution of vaccines and management of vaccinations. Politics has often conflicted with public health concerns. The States have been left to provide personal protective equipment (PPE) to medical personnel and first responders and to formulate their own guidance for protective measures.

Osteopathic considerations in pneumonia

2021 ◽  
pp. 14-20
Author(s):  
Taner B. Celebi ◽  
Jeffrey Muller ◽  
Michael J. Terzella
Keyword(s):  
United States ◽  
Risk Factors ◽  
Treatment Options ◽  
The United States ◽  
Special Consideration ◽  
Associated Risk Factors

Pneumonia contributed to nearly 3 million deaths worldwide in 2016 and 56,000 deaths in the United States alone in 2017, and as such, it is imperative for physicians to understand the causes, subtypes, associated risk factors and treatment options. This article will address each of these, as well as special consideration for the osteopathic approach to care.

Achieving Agility in Disaster Management

2011 ◽  
pp. 1-11
Author(s):  
John R. Harrald
Keyword(s):  
United States ◽  
Decision Making ◽  
Emergency Management ◽  
Open Systems ◽  
Social Science Research ◽  
Science Research ◽  
The United States ◽  
Organizational Systems ◽  
The Social ◽  
Professional Practitioners

A significant body of social science research has concluded that improvisation in distributed, collaborative, open systems is the key to success in responding to and recovering from extreme events. The evolution of emergency management in the United States since the 9-11 attacks has emphasized the development of doctrine, process, and structure. In earlier work I concluded that both the agility desired by the social sciences and the discipline created by the professional practitioners are essential. This article explores how agility can be developed within a disciplined system and concludes that the keys are the development of outcome based goals, adaptive leadership, and technology that supports collaborative sense-making and decision making in open, organizational systems.

The Emerging Hispanic Use of Online Health Information in the United States

2012 ◽  
pp. 251-265
Author(s):  
Nicole St. Germaine-McDaniel
Keyword(s):  
United States ◽  
Health Outcomes ◽  
Health Information ◽  
Sense Of Community ◽  
Treatment Options ◽  
The United States ◽  
English Speakers ◽  
Preventative Care ◽  
Spanish Speaking ◽  
Spanish Speaking Population

As health-information websites become more popular, healthcare corporations have worked quickly to create Spanish-language sites to reach the Spanish-speaking population. However, changes have to be made in order to effectively adapt to the Spanish-speaking audience. In order to be successful, site designers must create a sense of community by having interactive elements and by advertising these sites through radio or television with well-known celebrities or known figures in the healthcare realm. Further, care must be taken to ensure that the information in these sites is culturally appropriate for this audience. The successful health information website can be a strong tool for educating both Spanish and English speakers alike about preventative care, as well as treatment options, which in turn can improve health outcomes.

Delivering Psychological Services to Refugees Resettled in the United States

2019 ◽  
pp. 165-183
Author(s):  
Johanna E. Nilsson ◽  
Sally Stratmann ◽  
Aurora Molitoris ◽  
Marcella A. Beaumont ◽  
Jessica Horine
Keyword(s):  
Mental Health ◽  
United States ◽  
Mental Health Professionals ◽  
Mental Health Treatment ◽  
Treatment Options ◽  
The United States ◽  
Psychological Services ◽  
Health Needs ◽  
Mental Health Needs ◽  
The Status

Approximately 25 million refugees have fled their homelands internationally, and about 3 million have been resettled in the United States. The mental health needs of a population that has fled oppression, violence, and instability are diverse. This chapter seeks to provide a holistic overview of these needs. The introduction covers what defines the status of a refugee, current resettlement policies, and pre- and post-migration experiences and concerns among refugees, including barriers to basic services. Effective mental health treatment options and areas of competence for mental health professionals working with these individuals are discussed, along with future considerations for best meeting the mental health needs of refugees.

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