Design and Rationale of a Real-Life Study to Compare Treatment Strategies for Cardiovascular Risk Factors: The CRUCIAL Study

2010 ◽  
Vol 122 (2) ◽  
pp. 7-15 ◽  
Author(s):  
José Zamorano ◽  
Serap Erdine ◽  
Abel Pavia Lopez ◽  
Jae-Hyung Kim ◽  
Ayman Al Khadra ◽  
...  
2019 ◽  
Vol Volume 12 ◽  
pp. 297-307 ◽  
Author(s):  
Gábor Tomisa ◽  
Alpár Horváth ◽  
Zsuzsanna Szalai ◽  
Veronika Müller ◽  
Lilla Tamási

CNS Spectrums ◽  
2003 ◽  
Vol 8 (11) ◽  
pp. 824-831 ◽  
Author(s):  
Ramit Ravona-Springer ◽  
Michael Davidson ◽  
Shlomo Noy

ABSTRACTThe distinction between Alzheimer's disease and vascular dementia, the two most common types of dementia, has been undermined by recent advances in epidemiologic, clinical, imaging, and neuropathological studies. Cardiovascular risk factors, traditionally regarded as distinguishing criteria between the two entities, have been shown to be associated with both AD and vascular dementia. In this article, we propose mechanisms of action of cardiovascular risk factors in AD, suggest possible explanations for the overlap with vascular dementia and discuss the implications this might have on future differential diagnosis, research, and treatment strategies.


2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
B Igual Munoz ◽  
E S L C Elena Sanchez Lacuesta ◽  
J L D G Jose Luis Diez Gil ◽  
M F V Maria Ferre Valverdu ◽  
F T M Francisco Ten Morro ◽  
...  

Abstract Intramyocardial hemorrhage (IMH) is considered a marker of tissue damage severity in patients with reperfused ST-segment elevation myocardial infarction (STEMI) and has been associated with a poor prognosis despite successful revascularization of the culprit artery . We aim to study the impact of cardiovascular risk factors and treatment strategies on the presence of IMH studied with T2* -w cardiovascular magnetic resonance (CMR) in this clinical setting METHODS A prospective observational study including patients with repefused STEMI who underwent an MRI during the first week post-revascularization were conducted . The presence of IMH was analyzed in ECG triggered T2 * w sequences as presence of hipointensity area . Clinical data including cardiovascular risk factors and treatment strategies at cath lab were studied. RESULTS 94 patients with reperfused STEMI were included. Demographic data are shown at the the table. No significant association was observed between the presence of IMH and the different treatment strategies used. All data were introduced in a multivariate model including presence of thrombus, total ischemia time and culprit coronary artery. The analysis showed previous infarction as an independent risk factor (OR: 6 p = 0.03, CI: 1.1-29) while history of hypertension (OR: 0.9, p = 0.04, CI: 0.1- 0.9) and systolic blood pressure showed independent protective effect (OR: 0.3 p = 0.02 IC: 0.9-0.99.) CONCLUSIONS. 1. Previous infarction was shown to be an independent risk factor for IMH . 2. Arterial hypertension and systolic blood pressure showed a protective effect. Age (years) 62 ±13 Male sex 72 (77) Diabetes mellitus 32 (34) Hypertension 53 (56) Hyperlipidaemia 52 (55) Current or prior smoking 55 (58) Time to reperfusion 203 (142-300) Infarct-related artery LAD 38 (41) RCA 49 (52) Cx 7 (7) Infarct size (% LV mass) 18 ± 11 MO (% LV mass) 3.15 (1.44-5.48) Abstract P824 Figure. Intramyocardial hemorraghe T2* sequences


2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Philippe Latry ◽  
Mathieu Molimard ◽  
Bernard Dedieu ◽  
Thierry Couffinhal ◽  
Bernard Bégaud ◽  
...  

2018 ◽  
Vol 8 (11) ◽  
pp. 1267-1273 ◽  
Author(s):  
Yongshi Yang ◽  
Yin Wang ◽  
Lin Yang ◽  
Jingru Wang ◽  
Nan Huang ◽  
...  

2009 ◽  
Vol 71 (9) ◽  
pp. 937-943 ◽  
Author(s):  
Kaarin J. Anstey ◽  
Richard Burns ◽  
Peter Butterworth ◽  
Tim D. Windsor ◽  
Helen Christensen ◽  
...  

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