DISSEMINATED INTRAVASCULAR COAGULATION A primer for primary care physicians Diagnosis of this potentially life-threatening coagulation disorder can be confusing unless physicians are aware of when it might occur. Drs Messmore and Wehrmacher give a brief overview of the disease, highlight its causes, and explain options for its managment.

2002 ◽  
Vol 111 (3) ◽  
Author(s):  
Harry Messmore ◽  
William Wehrmacher
Keyword(s):  
Primary Care ◽  
Disseminated Intravascular Coagulation ◽  
Primary Care Physicians ◽  
Coagulation Disorder ◽  
Intravascular Coagulation ◽  
Life Threatening

scholarly journals ALK-Negative Anaplastic Large Cell Lymphoma Presenting as Disseminated Intravascular Coagulation and Hemophagocytic Lymphohistiocytosis: A Potentially Fatal Presentation

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Uroosa Ibrahim ◽  
Amina Saqib ◽  
Maryam Rehan ◽  
Jean Paul Atallah
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Anaplastic Large Cell Lymphoma ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Lymph Node Biopsy ◽  
Intravascular Coagulation ◽  
Primary Disorder ◽  
Life Threatening ◽  
Large Cell Lymphoma

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder that can be familial in etiology or a result of infections, malignancy, and autoimmune or inflammatory disorders. Disseminated intravascular coagulation (DIC) is common in patients admitted to intensive care units and can confound and delay the diagnosis of HLH. We present a case of a 69-year-old female who presented with dyspnea and malaise. Her condition declined rapidly with laboratory parameters consistent with DIC. In addition, she had a ferritin of 32,522 ng/mL, low haptoglobin, and elevated LDH, and bone marrow biopsy showed hemophagocytic lymphohistiocytes. She was started on HLH-directed therapy, and later, a diagnosis of ALK-negative anaplastic large cell lymphoma was made on an excisional inguinal lymph node biopsy specimen. Our case emphasizes the importance of prompt recognition, diagnosis, and treatment of HLH while workup for a primary disorder is still being pursued.

Paraneoplastic syndromes of gynecologic neoplasms.

1997 ◽  
Vol 15 (3) ◽  
pp. 1272-1282 ◽  
Author(s):  
A A Ashour ◽  
C F Verschraegen ◽  
A P Kudelka ◽  
J J Kavanagh
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Paraneoplastic Syndromes ◽  
Gynecologic Malignancies ◽  
Intravascular Coagulation ◽  
Underlying Malignancy ◽  
Life Threatening ◽  
Comprehensive Search ◽  
Gynecologic Neoplasms

PURPOSE AND DESIGN The purpose of this review is to define and describe the paraneoplastic syndromes associated with gynecologic neoplasms. A comprehensive search of MEDLINE from 1966 to January 1996 and Cancerlit was performed. One hundred twenty-two reports were reviewed. RESULTS Twenty-four paraneoplastic syndromes have been associated with gynecologic malignancies. Six anatomic systems are affected by these syndromes. However, except for disseminated intravascular coagulation and hypercalcemia, these syndromes are rare. CONCLUSION Paraneoplastic syndromes are not frequently associated with gynecologic malignancies. The diagnosis of these syndromes is essential, as they can be occasionally life-threatening. Some paraneoplastic syndromes can be used as marker of progression or regression of the underlying malignancy.

scholarly journals Linfohistiocitose Hemofagocítica Secundária a Infeção por Epstein-Barr: Raridade e Gravidade num Adulto Imunocompetente

2019 ◽  
Vol 32 (1) ◽  
pp. 78
Author(s):  
Andreia Sofia Costa ◽  
Anusca Paixão ◽  
Henrique Santos ◽  
Fernando Salvador
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Epstein Barr Virus ◽  
Clinical Case ◽  
Specific Treatment ◽  
Supportive Therapy ◽  
Intravascular Coagulation ◽  
Barr Virus ◽  
Life Threatening ◽  
Epstein Barr

Hemophagocytic lymphohistiocytosis is a rare, aggressive and life-threatening syndrome, characterized by an excessive immune activation. It is triggered by multiple stimuli, with infections having an important role. The most common infectious trigger is viral infection, particularly by Epstein-Barr virus. Coagulation disorders are common in hemophagocytic lymphohistiocytosis and disseminated intravascular coagulation can be present in severe cases. We report a clinical case of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis, complicated with disseminated intravascular coagulation which evolved favorably with only supportive therapy and without specific treatment.

scholarly journals Massive Bleeding as the First Clinical Manifestation of Metastatic Prostate Cancer due to Disseminated Intravascular Coagulation with Enhanced Fibrinolysis

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Mónica Palma Anselmo ◽  
Gustavo Nobre de Jesus ◽  
João Madeira Lopes ◽  
Rui M. M. Victorino ◽  
João Meneses Santos
Keyword(s):  
Prostate Cancer ◽  
Disseminated Intravascular Coagulation ◽  
Case Reports ◽  
Specific Antigen ◽  
Aminocaproic Acid ◽  
Massive Bleeding ◽  
Coagulation Disorder ◽  
Intravascular Coagulation ◽  
Multiple Bone Metastases ◽  
Epsilon Aminocaproic Acid

Disseminated intravascular coagulation (DIC) is the most frequent coagulation disorder associated with metastatic prostate adenocarcinoma. However, DIC with enhanced fibrinolysis as an initial presentation of prostate cancer is extremely rare. The appropriate treatment to control bleeding in these situations is challenging, controversial, and based on isolated case reports in the literature. A 66-year-old male presented at the emergency department with acute severe spontaneous ecchymoses localized to the limbs, laterocervical hematoma, and hemothorax. Prostate specific antigen level was 385 μg/L, bone scintigraphy revealed multiple bone metastases, and prostate biopsy confirmed adenocarcinoma (Gleason 9; 4 + 5). Laboratory investigation showed a pattern of enhanced fibrinolysis rather than the more common intravascular coagulation mechanism. Epsilon aminocaproic acid in monotherapy was initiated with a clear and rapid control of bleeding manifestations. This rare case of massive bleeding due to DIC with enhanced fibrinolysis as the first manifestation of prostate cancer suggests that in selected cases where the acute bleeding dyscrasia is clearly associated with a dominant fibrinolysis mechanism it is possible to use an approach of monotherapy with antifibrinolytics.

scholarly journals Management of Chronic Disseminated Intravascular Coagulation Associated with Aortic Aneurysm/Dissection

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Shigeru Koba ◽  
Tomoya Yamaguchi ◽  
Kenji Miki ◽  
Hiroshi Makihara ◽  
Shinsaku Imashuku
Keyword(s):  
Aortic Aneurysm ◽  
Elderly Patients ◽  
Disseminated Intravascular Coagulation ◽  
Underlying Disease ◽  
Hemorrhagic Diathesis ◽  
Disease Extent ◽  
Intravascular Coagulation ◽  
Life Threatening ◽  
Aneurysm Dissection ◽  
Uncertain Etiology

Disseminated intravascular coagulation (DIC) is a systemic life-threatening process that can cause thrombosis and hemorrhage. Chronic DIC has been associated with aortic aneurysm/dissection. Aortic aneurysm/dissection should be included in the differential diagnosis of elderly patients with hemorrhagic diathesis due to DIC of uncertain etiology. Treatment depends on various factors, including the severity of underlying disease, extent of DIC, and patient comorbidities, as well as the ability of the patient to maintain activities of daily living once discharged from the hospital. This report describes the clinical characteristics of four elderly patients with chronic DIC associated with aortic aneurysm/dissection who were treated in our institution. We also offer the recommendations around most appropriate nonsurgical treatment of these patients.

AM:STARs: Acute Emergencies in Adolescents, Vol. 26, No. 3

2016 ◽  
Keyword(s):  
Primary Care ◽  
Emergency Department ◽  
Primary Care Physicians ◽  
Health Problems ◽  
Health Concerns ◽  
Life Threatening

Adolescents frequently present to the emergency department or to primary care physicians for acute health concerns that range from minor to life-threatening. This issue of AM:STARs focuses on many of the more urgent and emergent health problems and concerns that bring adolescents to clinics, private offices, and emergency department settings.

Sign in / Sign up

Export Citation Format

Share Document