scholarly journals Ortho- and Ectopic Zebrafish Xeno-Engraftment of Ocular Melanoma to Recapitulate Primary Tumor and Experimental Metastasis Development

10.3791/62356 ◽  
2021 ◽  
Author(s):  
Arwin Groenewoud ◽  
Jie Yin ◽  
B. Ewa Snaar-Jagalska
Keyword(s):  
Primary Tumor ◽  
Ocular Melanoma ◽  
Experimental Metastasis ◽  
Metastasis Development

scholarly journals P2.03b-005 Correlation between Primary Tumor Location and Brain Metastasis Development or Peritumoral Brain Edema in Lung Cancer

2017 ◽  
Vol 12 (1) ◽  
pp. S935
Author(s):  
Katalin Fabian ◽  
Márton Gyulai ◽  
József Furák ◽  
Péter Várallyay ◽  
Márta Jäckel ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Brain Metastasis ◽  
Brain Edema ◽  
Primary Tumor ◽  
Tumor Location ◽  
Primary Tumor Location ◽  
Peritumoral Brain Edema ◽  
Metastasis Development

scholarly journals Overexpression of Smad7 Blocks Primary Tumor Growth and Lung Metastasis Development in Osteosarcoma

2014 ◽  
Vol 20 (19) ◽  
pp. 5097-5112 ◽  
Author(s):  
Audrey Lamora ◽  
Julie Talbot ◽  
Gwenola Bougras ◽  
Jérôme Amiaud ◽  
Marion Leduc ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Lung Metastasis ◽  
Primary Tumor ◽  
Primary Tumor Growth ◽  
Metastasis Development

Experimental metastasis and primary tumor growth in mice with hemophilia A

2006 ◽  
Vol 4 (5) ◽  
pp. 1056-1062 ◽  
Author(s):  
F. LANGER ◽  
A. AMIRKHOSRAVI ◽  
S. B. INGERSOLL ◽  
J. M. WALKER ◽  
B. SPATH ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Primary Tumor ◽  
Hemophilia A ◽  
Experimental Metastasis ◽  
Primary Tumor Growth

scholarly journals Comparison of tumor microenvironment in primary and paired metastatic ER+/HER2- breast cancers: results of a pilot study

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Annalisa Zeppellini ◽  
Stefania Galimberti ◽  
Biagio Eugenio Leone ◽  
Claudia Pacifico ◽  
Francesca Riva ◽  
...  
Keyword(s):  
Pilot Study ◽  
Tumor Microenvironment ◽  
Cancer Progression ◽  
Primary Tumor ◽  
Control Group ◽  
Breast Cancers ◽  
Dynamic Setting ◽  
Metastasis Development ◽  
Metastatic Process

Abstract Background Tumor microenvironment (TME) is a dynamic setting and changes in TILs and their subpopulations are potential candidates to influence the metastatic process. Aim of this pilot study is to describe the changes occurring between primary breast cancers and their paired metastases in terms of TILs composition. To assess if these changes influence the process of metastasis development, we used a control group of patients. Methods We retrospectively identified 18 Luminal patients, for whom primary and metastatic tissue were available (cases) and 18 paired-matched patients (controls), not relapsed after at least 9 years of follow-up, and we quantified TILs and their composition (i.e. T CD8+ and CD4+/FOXP3+). The presence of TILs was defined as ≥10%. Results Our results showed that the microenvironment composition of relapsed patients was poor of TILs (median = 5%, I-III quartiles = 0.6–5%), CD8+ (2.5%, 0–5%) and CD4+/FOXP3 + (0%, 0–0.6%) in the primary tumor. Comparable results were observed in their related metastases (TILs 3.8%, 0.6–5%; CD8+ 0%, 0–1.3%; CD4+/FOXP3+ 0%,0–1.9%). On the contrary, the microenvironment in the control group was richer of TILs (5%, 5–17.5%) in comparison to cases, both in primary tumor (p = 0.035) and related metastases (p = 0.018). Although CD8+ in controls were similar to cases at primary tumor (p = 0.6498), but not at metastasis (p = 0.0223), they expressed only one part on the TILs subpopulations (p = 0.0060), while TILs in the cases at primary tumor were almost completely CD8+ (p = 0.5034). Conclusions These findings suggest that the lack of activation of immune system in the primary tumor might influence the multifactor process of cancer progression.

Platelet Glycoprotein 1b-1X in Hemostasis and Malignancy.

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. sci-21-sci-21
Author(s):  
Jerry Ware ◽  
Shashank Jain
Keyword(s):  
Breast Cancer ◽  
Primary Tumor ◽  
Thrombus Formation ◽  
Coagulation Factors ◽  
Tumor Burden ◽  
Membrane Receptors ◽  
Platelet Glycoprotein ◽  
Experimental Metastasis ◽  
Arterial Circulation ◽  
New Information

Abstract The platelet paradigm in hemostasis and thrombosis involves an initiation step dependent upon platelet membrane receptors binding to ligands on a damaged or inflamed vascular surface. Once bound to the surface, platelets provide a unique microenvironment supporting the accumulation of more platelets and the elaboration of a fibrin-rich network produced by coagulation factors. This paradigm has been established from decades of research. The platelet-specific receptor, glycoprotein (GP) Ib-IX, is critical in this process and can initiate the formation of a platelet-rich thrombus by tethering the platelet to a thrombogenic surface. Several ligands binding to GP Ib-IX have been identified, but von Willebrand factor (vWF) and the resultant GP Ib-IX/vWF axis has emerged as a major initiator of platelet thrombus formation in the arterial circulation. Newer, emerging data supports a role for platelets in pathological events beyond the prevention of blood loss. We have obtained data supporting the hypothesis that platelet GP Ib-IX contributes to malignancy. Knockout and transgenic mouse colonies have been generated in our laboratory and bred to C57BL/6J animals to generate several congenic strains (> 10 generation backcrosses) with dysfunctional platelet GP Ib-IX. These colonies have been used to characterize tumor metastasis and primary tumor growth in syngeneic models where the host animals are immunocompetent. The results demonstrate platelet GP Ib-IX contributes to tumorigenesis, as a functional absence of GP Ib-IX correlates with a significant reduction in the number of metastatic foci using models of experimental metastasis. In addition, an absence of GP Ib-IX significantly reduces primary tumor burden. A second series of experiments has determined that platelet GP VI, a key activation receptor on the surface of platelets also contributes to progression of experimental metastasis. The importance of metastasis in the prognosis for recovery from cancer can not be over-emphasized. Indeed, the spread of metastatic disease represents a fundamental change in significantly shortening the lifespan of patients with breast cancer. Thus, understanding the molecules that regulate metastasis identifies potential targets for therapeutic intervention that could significantly improve the prognosis for the breast cancer patient. Several decades of prior work in hemostasis and thrombosis has placed this project in a position to quickly provide new information and understanding on the links between hemostasis and cancer.

scholarly journals Inhibition of tissue factor by ixolaris reduces primary tumor growth and experimental metastasis in a murine model of melanoma

2012 ◽  
Vol 130 (3) ◽  
pp. e163-e170 ◽  
Author(s):  
Andreia Da Silva de Oliveira ◽  
Luize G. Lima ◽  
Andréa Mariano-Oliveira ◽  
Daniel E. Machado ◽  
Luiz E. Nasciutti ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Tissue Factor ◽  
Murine Model ◽  
Primary Tumor ◽  
Experimental Metastasis ◽  
Primary Tumor Growth

Significance of Primary Tumor Location and Histology for Brain Metastasis Development and Peritumoral Brain Edema in Lung Cancer

Oncology ◽  
2016 ◽  
Vol 91 (5) ◽  
pp. 237-242 ◽  
Author(s):  
Katalin Fábián ◽  
Márton Gyulai ◽  
József Furák ◽  
Péter Várallyay ◽  
Márta Jäckel ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Brain Metastasis ◽  
Brain Edema ◽  
Primary Tumor ◽  
Tumor Location ◽  
Primary Tumor Location ◽  
Peritumoral Brain Edema ◽  
Metastasis Development

404: Immune Mediated Survival Advantage and Primary Tumor Control of Cryoablation Compared to Nephrectomy in a Murine Model of Advanced Renal Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 132-132 ◽  
Author(s):  
Sean P. Hedican ◽  
Eric R. Wilkinson ◽  
Thomas F. Warner ◽  
Fred T. Lee ◽  
Stephen Y. Nakada
Keyword(s):  
Renal Cancer ◽  
Murine Model ◽  
Primary Tumor ◽  
Survival Advantage ◽  
Tumor Control ◽  
Advanced Renal Cancer ◽  
Immune Mediated
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