Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection

10.3791/62115 ◽  
2021 ◽  
Author(s):  
Zhe Zhang Ryan Lew ◽  
Jing Liu ◽  
Hsiao Hui Ong ◽  
Vivian Jiayi Tan ◽  
Annika Luukkainen ◽  
...  
Keyword(s):  
Virus Infection ◽  
Cell Activation ◽  
Respiratory Virus ◽  
Immune Cell ◽  
Innate Immune ◽  
Innate Immune Cell ◽  
Immune Cell Activation ◽  
Culture Model ◽  
Respiratory Virus Infection ◽  
Contact Free

scholarly journals Antibody Conjugation of Fluorescent Nanodiamonds for Targeted Innate Immune Cell Activation

2021 ◽  
Author(s):  
Lorena P. Suarez-Kelly ◽  
Steven H. Sun ◽  
Casey Ren ◽  
Isaac V. Rampersaud ◽  
David Albertson ◽  
...  
Keyword(s):  
Cell Activation ◽  
Immune Cell ◽  
Innate Immune ◽  
Innate Immune Cell ◽  
Immune Cell Activation ◽  
Antibody Conjugation ◽  
Fluorescent Nanodiamonds

scholarly journals Proinflammatory Effects of Respiratory Syncytial Virus–Induced Epithelial HMGB1 on Human Innate Immune Cell Activation

2018 ◽  
Vol 201 (9) ◽  
pp. 2753-2766 ◽  
Author(s):  
Kempaiah Rayavara ◽  
Alexander Kurosky ◽  
Susan J. Stafford ◽  
Nisha J. Garg ◽  
Allan R. Brasier ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Cell Activation ◽  
Immune Cell ◽  
Innate Immune ◽  
Innate Immune Cell ◽  
Immune Cell Activation ◽  
Syncytial Virus

scholarly journals Brain TSPO-PET predicts later disease progression independent of relapses in multiple sclerosis

Brain ◽  
2020 ◽  
Vol 143 (11) ◽  
pp. 3318-3330
Author(s):  
Marcus Sucksdorff ◽  
Markus Matilainen ◽  
Jouni Tuisku ◽  
Eero Polvinen ◽  
Anna Vuorimaa ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Disease Progression ◽  
Cell Activation ◽  
Immune Cell ◽  
Innate Immune ◽  
Innate Immune Cell ◽  
Immune Cell Activation ◽  
Normal Appearing White Matter ◽  
Multiple Sclerosis Disease

Abstract Overactivation of microglia is associated with most neurodegenerative diseases. In this study we examined whether PET-measurable innate immune cell activation predicts multiple sclerosis disease progression. Activation of microglia/macrophages was measured using the 18-kDa translocator protein (TSPO)-binding radioligand 11C-PK11195 and PET imaging in 69 patients with multiple sclerosis and 18 age- and sex-matched healthy controls. Radioligand binding was evaluated as the distribution volume ratio from dynamic PET images. Conventional MRI and disability measurements using the Expanded Disability Status Scale were performed for patients at baseline and 4.1 ± 1.9 (mean ± standard deviation) years later. Fifty-one (74%) of the patients were free of relapses during the follow-up period. Patients had increased activation of innate immune cells in the normal-appearing white matter and in the thalamus compared to the healthy control group (P = 0.033 and P = 0.003, respectively, Wilcoxon). Forward-type stepwise logistic regression was used to assess the best variables predicting disease progression. Baseline innate immune cell activation in the normal-appearing white matter was a significant predictor of later progression when the entire multiple sclerosis cohort was assessed [odds ratio (OR) = 4.26; P = 0.048]. In the patient subgroup free of relapses there was an association between macrophage/microglia activation in the perilesional normal-appearing white matter and disease progression (OR = 4.57; P = 0.013). None of the conventional MRI parameters measured at baseline associated with later progression. Our results strongly suggest that innate immune cell activation contributes to the diffuse neural damage leading to multiple sclerosis disease progression independent of relapses.

scholarly journals Exploiting Innate Immune Cell Activation of a Copper-Dependent Antimicrobial Agent during Infection

2014 ◽  
Vol 21 (8) ◽  
pp. 977-987 ◽  
Author(s):  
Richard A. Festa ◽  
Marian E. Helsel ◽  
Katherine J. Franz ◽  
Dennis J. Thiele
Keyword(s):  
Antimicrobial Agent ◽  
Cell Activation ◽  
Immune Cell ◽  
Innate Immune ◽  
Innate Immune Cell ◽  
Immune Cell Activation

Rhamnogalacturonan-I-Type Polysaccharide Purified from Broccoli Exerts Anti-Metastatic Activities Via Innate Immune Cell Activation

2019 ◽  
Vol 22 (5) ◽  
pp. 451-459 ◽  
Author(s):  
Bong-Shin Kwak ◽  
Dahyun Hwang ◽  
Sue Jung Lee ◽  
Hyuk-Jun Choi ◽  
Ho-Young Park ◽  
...  
Keyword(s):  
Cell Activation ◽  
Immune Cell ◽  
Innate Immune ◽  
Innate Immune Cell ◽  
Rhamnogalacturonan I ◽  
Immune Cell Activation

scholarly journals Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo

2016 ◽  
Vol 254 ◽  
pp. 228-236 ◽  
Author(s):  
Siroon Bekkering ◽  
Inge van den Munckhof ◽  
Tim Nielen ◽  
Evert Lamfers ◽  
Charles Dinarello ◽  
...  
Keyword(s):  
Cell Activation ◽  
Immune Cell ◽  
Innate Immune ◽  
Innate Immune Cell ◽  
Immune Cell Activation ◽  
Epigenetic Remodeling

Modulation of innate immune cell activation and function by Polysaccharide Krestin (PSK)

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
CA Wenner ◽  
H Wang ◽  
A Hill-Force ◽  
MR Martzen ◽  
MR Verneris
Keyword(s):  
Cell Activation ◽  
Immune Cell ◽  
Innate Immune ◽  
Innate Immune Cell ◽  
Immune Cell Activation ◽  
And Function
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