Using Computer-based Image Analysis to Improve Quantification of Lung Metastasis in the 4T1 Breast Cancer Model

10.3791/61805 ◽  
2020 ◽  
Author(s):  
Margaret A. Nagai-Singer ◽  
Alissa Hendricks-Wenger ◽  
Rebecca M. Brock ◽  
Holly A. Morrison ◽  
Juselyn D. Tupik ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Image Analysis ◽  
Lung Metastasis ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
Computer Based ◽  
4T1 Breast Cancer

scholarly journals Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade

2017 ◽  
Vol 6 (6) ◽  
pp. e1316437 ◽  
Author(s):  
Chiara Secondini ◽  
Oriana Coquoz ◽  
Lorenzo Spagnuolo ◽  
Thibaud Spinetti ◽  
Sanam Peyvandi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lung Metastasis ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
4T1 Breast Cancer

scholarly journals Systemic inflammation promotes lung metastasis via E-selectin upregulation in mouse breast cancer model

2014 ◽  
Vol 15 (6) ◽  
pp. 789-796 ◽  
Author(s):  
Man Jiang ◽  
Xiaoya Xu ◽  
Yuli Bi ◽  
Jiying Xu ◽  
Chengyong Qin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lung Metastasis ◽  
Systemic Inflammation ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
Mouse Breast Cancer

scholarly journals Theranostic probe for simultaneous in vivo photoacoustic imaging and confined photothermolysis by pulsed laser at 1064 nm in 4T1 breast cancer model

Nanoscale ◽  
2014 ◽  
Vol 6 (24) ◽  
pp. 15228-15235 ◽  
Author(s):  
Min Zhou ◽  
Geng Ku ◽  
Laura Pageon ◽  
Chun Li
Keyword(s):  
Breast Cancer ◽  
Photoacoustic Imaging ◽  
Pulsed Laser ◽  
Tumor Ablation ◽  
Cancer Model ◽  
Single Compartment ◽  
Breast Cancer Model ◽  
Nanoparticle System ◽  
4T1 Breast Cancer

A single-compartment nanoparticle system mediates dual photoacoustic imaging and confined thermolysis for tumor ablation.

scholarly journals Increased Expression of P-Glycoprotein Is Associated with Doxorubicin Chemoresistance in the Metastatic 4T1 Breast Cancer Model

2011 ◽  
Vol 178 (2) ◽  
pp. 838-852 ◽  
Author(s):  
Lili Bao ◽  
Aliyya Haque ◽  
Kamilah Jackson ◽  
Sidhartha Hazari ◽  
Krzysztof Moroz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Model ◽  
P Glycoprotein ◽  
Breast Cancer Model ◽  
4T1 Breast Cancer

scholarly journals Osteopontin binds ICOSL promoting tumor metastasis

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Davide Raineri ◽  
Chiara Dianzani ◽  
Giuseppe Cappellano ◽  
Federica Maione ◽  
Gianluca Baldanzi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Metastasis ◽  
Immune Checkpoints ◽  
Cancer Model ◽  
Therapeutic Approaches ◽  
Breast Cancer Model ◽  
4T1 Breast Cancer ◽  
Anti Tumor Activity

Abstract ICOSL/ICOS are costimulatory molecules pertaining to immune checkpoints; their binding transduces signals having anti-tumor activity. Osteopontin (OPN) is here identified as a ligand for ICOSL. OPN binds a different domain from that used by ICOS, and the binding induces a conformational change in OPN, exposing domains that are relevant for its functions. Here we show that in vitro, ICOSL triggering by OPN induces cell migration, while inhibiting anchorage-independent cell growth. The mouse 4T1 breast cancer model confirms these data. In vivo, OPN-triggering of ICOSL increases angiogenesis and tumor metastatization. The findings shed new light on ICOSL function and indicate that another partner beside ICOS may be involved; they also provide a rationale for developing alternative therapeutic approaches targeting this molecular trio.

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