Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

10.3791/61546 ◽  
2020 ◽  
Author(s):  
Michaela Olthoff ◽  
Federico Franchi ◽  
Karen M. Peterson ◽  
Ramasamy Paulmurugan ◽  
Martin Rodriguez-Porcel
Keyword(s):  
Stem Cells ◽  
Reperfusion Injury ◽  
Murine Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Intramyocardial Delivery

scholarly journals Murine Model of Intestinal Ischemia-reperfusion Injury

10.3791/53881 ◽  
2016 ◽  
Author(s):  
Ekaterina O. Gubernatorova ◽  
Ernesto Perez-Chanona ◽  
Ekaterina P. Koroleva ◽  
Christian Jobin ◽  
Alexei V. Tumanov
Keyword(s):  
Reperfusion Injury ◽  
Murine Model ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Intestinal Ischemia Reperfusion

Flaxseed Protects Against the Inflammatory Phase of Lung Ischemia Reperfusion Injury in a Murine Model

2010 ◽  
Vol 158 (2) ◽  
pp. 358
Author(s):  
S.S. Razi ◽  
G. Schwartz ◽  
D. Boone ◽  
X. Li ◽  
S. Belsley ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Murine Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Inflammatory Phase

Protective Effects of Micro-Injected Adipose-Derived Mesenchymal Stem Cells on Ovarian Ischemia/Reperfusion Injury in Rats

2021 ◽  
Vol 7 (4) ◽  
pp. 237
Author(s):  
Burcu Kasap ◽  
Sukru Kasap ◽  
Seda Vatansever ◽  
Remziye Kendirci ◽  
Osman Yilmaz ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Protective Effects

scholarly journals Targeting chronic cardiac remodeling with cardiac progenitor cells in a murine model of ischemia/reperfusion injury

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0173657 ◽  
Author(s):  
Janine C. Deddens ◽  
Dries A. Feyen ◽  
Peter-Paul Zwetsloot ◽  
Maike A. Brans ◽  
Sailay Siddiqi ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Progenitor Cells ◽  
Murine Model ◽  
Cardiac Remodeling ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cardiac Progenitor Cells

scholarly journals PR-39, a potent neutrophil inhibitor, attenuates myocardial ischemia-reperfusion injury in mice

2000 ◽  
Vol 279 (6) ◽  
pp. H2824-H2828 ◽  
Author(s):  
Michaela R. Hoffmeyer ◽  
Rosario Scalia ◽  
Chris R. Ross ◽  
Steven P. Jones ◽  
David J. Lefer
Keyword(s):  
Myocardial Ischemia ◽  
Reperfusion Injury ◽  
Murine Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Polymorphonuclear Neutrophil ◽  
Leukocyte Rolling ◽  
Rat Mesentery ◽  
Myocardial Ischemia Reperfusion Injury ◽  
Myocardial Ischemia Reperfusion

We investigated the effects of PR-39, a recently discovered neutrophil inhibitor, in a murine model of myocardial ischemia-reperfusion injury. Mice were given an intravenous injection of vehicle ( n = 12) or PR-39 ( n = 9) and subjected to 30 min of coronary artery occlusion followed by 24 h of reperfusion. In addition, the effects of PR-39 on leukocyte rolling and adhesion were studied utilizing intravital microscopy of the rat mesentery. The area-at-risk per left ventricle was similar in vehicle- and PR-39-treated mice. However, myocardial infarct per risk area was significantly ( P < 0.01) reduced in PR-39 treated hearts (21.0 ± 3.8%) compared with vehicle (47.1 ± 4.8%). Histological analysis of ischemic reperfused myocardium demonstrated a significant ( P < 0.01) reduction in polymorphonuclear neutrophil (PMN) accumulation in PR-39-treated hearts ( n = 6, 34.3 ± 1.7 PMN/mm2) compared with vehicle-treated myocardium ( n = 6, 59.7 ± 3.1 PMN/mm2). In addition, PR-39 significantly ( P < 0.05) attenuated leukocyte rolling and adherence in rat inflamed mesentery. These results indicate that PR-39 inhibits leukocyte recruitment into inflamed tissue and attenuated myocardial reperfusion injury in a murine model of myocardial ischemia-reperfusion.

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