scholarly journals Subcellular Fractionation of Primary Chronic Lymphocytic Leukemia Cells to Monitor Nuclear/Cytoplasmic Protein Trafficking

10.3791/60426 ◽  
2019 ◽  
Author(s):  
Jodie Hay ◽  
Michael W. Moles ◽  
Jennifer Cassels ◽  
Alison M. Michie
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Protein Trafficking ◽  
Subcellular Fractionation ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Cytoplasmic Protein ◽  
Primary Chronic Lymphocytic Leukemia

scholarly journals Genetic modification of primary chronic lymphocytic leukemia cells with a lentivirus expressing CD38

Haematologica ◽  
2010 ◽  
Vol 95 (3) ◽  
pp. 514-517 ◽  
Author(s):  
L. Pearce ◽  
L. Morgan ◽  
T. T. Lin ◽  
S. Hewamana ◽  
R. J. Matthews ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Genetic Modification ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Primary Chronic Lymphocytic Leukemia

scholarly journals Evaluation of bendamustine in combination with fludarabine in primary chronic lymphocytic leukemia cells

Blood ◽  
2014 ◽  
Vol 123 (24) ◽  
pp. 3780-3789 ◽  
Author(s):  
Amal A. El-Mabhouh ◽  
Mary L. Ayres ◽  
Elizabeth J. Shpall ◽  
Veerabhadran Baladandayuthapani ◽  
Michael J. Keating ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Dna Synthesis ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Unscheduled Dna Synthesis ◽  
Key Points ◽  
Primary Chronic Lymphocytic Leukemia

Key Points The fludarabine and bendamustine combination is cytotoxic to CLL cells even in the presence of a protective microenvironment. H2AX activation was maximum with the combination, and unscheduled DNA synthesis induced by bendamustine was blocked by fludarabine.

Sign in / Sign up

Export Citation Format

Share Document