Isolation and Characterization of Patient-derived Pancreatic Ductal Adenocarcinoma Organoid Models

10.3791/60364 ◽  
2020 ◽  
Author(s):  
Hervé Tiriac ◽  
Randall French ◽  
Andrew M. Lowy
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Ductal Adenocarcinoma ◽  
Isolation And Characterization

scholarly journals Omics Approaches in Pancreatic Adenocarcinoma

Cancers ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1052
Author(s):  
Iranzu González-Boja ◽  
Antonio Viúdez ◽  
Saioa Goñi ◽  
Enrique Santamaria ◽  
Estefania Carrasco-García ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Survival Rate ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Ductal Adenocarcinoma ◽  
Curative Intent ◽  
Pancreatic Cancers ◽  
Wide Range ◽  
Prevention And Treatment ◽  
Shed Light

Pancreatic ductal adenocarcinoma, which represents 80% of pancreatic cancers, is mainly diagnosed when treatment with curative intent is not possible. Consequently, the overall five-year survival rate is extremely dismal—around 5% to 7%. In addition, pancreatic cancer is expected to become the second leading cause of cancer-related death by 2030. Therefore, advances in screening, prevention and treatment are urgently needed. Fortunately, a wide range of approaches could help shed light in this area. Beyond the use of cytological or histological samples focusing in diagnosis, a plethora of new approaches are currently being used for a deeper characterization of pancreatic ductal adenocarcinoma, including genetic, epigenetic, and/or proteo-transcriptomic techniques. Accordingly, the development of new analytical technologies using body fluids (blood, bile, urine, etc.) to analyze tumor derived molecules has become a priority in pancreatic ductal adenocarcinoma due to the hard accessibility to tumor samples. These types of technologies will lead us to improve the outcome of pancreatic ductal adenocarcinoma patients.

Morphologic Characterization of Pancreatic Ductal Adenocarcinoma after Neoadjuvant Therapy

Pancreatology ◽  
2017 ◽  
Vol 17 (3) ◽  
pp. S20 ◽  
Author(s):  
Lena Haeberle ◽  
Anne-Christine Kapp ◽  
Irene Esposito
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Neoadjuvant Therapy ◽  
Ductal Adenocarcinoma

Molecular characterization of early precursor lesions of pancreatic ductal adenocarcinoma

Pancreatology ◽  
2018 ◽  
Vol 18 (4) ◽  
pp. S4
Author(s):  
Lisa Frohn ◽  
Lena Häberle ◽  
Wolfgang Göring ◽  
Matthias Wirth ◽  
Irene Esposito
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Molecular Characterization ◽  
Ductal Adenocarcinoma ◽  
Precursor Lesions

The Characterization of “Islet Invasion” in pancreatic Ductal adenocarcinoma

Pancreatology ◽  
2018 ◽  
Vol 18 (4) ◽  
pp. S71
Author(s):  
Ayse Ceren Mutgan ◽  
Umut Calisan ◽  
Yusuf Ceyhun Erdogan ◽  
Helmut Friess ◽  
Güralp O. Ceyhan ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Ductal Adenocarcinoma

scholarly journals The characterization of “islet invasion” in pancreatic ductal adenocarcinoma

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S578 ◽  
Author(s):  
I.E. Demir ◽  
A.C. Mutgan ◽  
H. Friess ◽  
G.O. Ceyhan
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Ductal Adenocarcinoma

scholarly journals Characterization of a dual BET / HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma

2020 ◽  
Vol 147 (10) ◽  
pp. 2847-2861 ◽  
Author(s):  
Xin Zhang ◽  
Tim Zegar ◽  
Tim Weiser ◽  
Feda H. Hamdan ◽  
Benedict‐Tilman Berger ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Hdac Inhibitor ◽  
Ductal Adenocarcinoma

scholarly journals Comparative Characterization of Stroma Cells and Ductal Epithelium in Chronic Pancreatitis and Pancreatic Ductal Adenocarcinoma

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e94357 ◽  
Author(s):  
Ole Helm ◽  
Ruben Mennrich ◽  
Domantas Petrick ◽  
Lisa Goebel ◽  
Sandra Freitag-Wolf ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Ductal Adenocarcinoma ◽  
Ductal Epithelium ◽  
Comparative Characterization

Establishment and Characterization of a New Cell Line (SPH) Derived From a Pancreatic Ductal Adenocarcinoma

Pancreas ◽  
2007 ◽  
Vol 35 (2) ◽  
pp. 188-189
Author(s):  
Dalu Kong ◽  
Nobukazu Nishino ◽  
Miki Shibusawa ◽  
Mitsuo Kusano
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Cell Line ◽  
Ductal Adenocarcinoma ◽  
New Cell Line

Tissue characterization of components of the antigen processing machinery in pancreatic ductal adenocarcinoma

Pancreatology ◽  
2018 ◽  
Vol 18 (4) ◽  
pp. S66-S67
Author(s):  
Greta Donisi ◽  
Giovanni Francesco Castino ◽  
Giovanni Capretti ◽  
Nina Cortese ◽  
Francesca Gavazzi ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Antigen Processing ◽  
Tissue Characterization ◽  
Ductal Adenocarcinoma ◽  
Antigen Processing Machinery ◽  
Processing Machinery
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