scholarly journals Isolation of Specific Neuron Populations from Roundworm Caenorhabditis elegans

10.3791/60145 ◽  
2019 ◽  
Author(s):  
Edward M. Germany ◽  
Nataliya Zahayko ◽  
Oleh Khalimonchuk
Keyword(s):  
Caenorhabditis Elegans ◽  
Neuron Populations ◽  
Specific Neuron

scholarly journals Targeting Cre Recombinase to Specific Neuron Populations with Bacterial Artificial Chromosome Constructs

2007 ◽  
Vol 27 (37) ◽  
pp. 9817-9823 ◽  
Author(s):  
S. Gong ◽  
M. Doughty ◽  
C. R. Harbaugh ◽  
A. Cummins ◽  
M. E. Hatten ◽  
...  
Keyword(s):  
Bacterial Artificial Chromosome ◽  
Artificial Chromosome ◽  
Cre Recombinase ◽  
Neuron Populations ◽  
Specific Neuron

scholarly journals A regulatory cascade of three transcription factors in a single specific neuron, DVC, in Caenorhabditis elegans

Gene ◽  
2012 ◽  
Vol 494 (1) ◽  
pp. 73-84 ◽  
Author(s):  
Huiyun Feng ◽  
John S. Reece-Hoyes ◽  
Albertha J.M. Walhout ◽  
Ian A. Hope
Keyword(s):  
Transcription Factors ◽  
Caenorhabditis Elegans ◽  
Regulatory Cascade ◽  
Specific Neuron

scholarly journals Fast retrograde access to projection neuron circuits underlying vocal learning in songbirds

2020 ◽  
Author(s):  
DN Düring ◽  
F Dittrich ◽  
MD Rocha ◽  
RO Tachibana ◽  
C Mori ◽  
...  
Keyword(s):  
Dopaminergic Neurons ◽  
Morphological Analysis ◽  
Vocal Learning ◽  
Projection Neuron ◽  
Neuron Populations ◽  
And Function ◽  
Genetic Targeting ◽  
Learning Circuits ◽  
Specific Neuron

SummaryUnderstanding the structure and function of neural circuits underlying speech and language is a vital step towards better treatments for diseases of these systems. Songbirds, among the few animal orders that share with humans the ability to learn vocalizations from a conspecific, have provided many insights into the neural mechanisms of vocal development. However, research into vocal learning circuits has been hindered by a lack of tools for rapid genetic targeting of specific neuron populations to meet the quick pace of developmental learning. Here, we present a new viral tool that enables fast and efficient retrograde access to projection neuron populations. In zebra finches, Bengalese finches, canaries, and mice, we demonstrate fast retrograde labeling of cortical or dopaminergic neurons. We further demonstrate the suitability of our construct for detailed morphological analysis, for in vivo imaging of calcium activity, and for multicolor brainbow labeling.

The glycomes of Caenorhabditis elegans and other model organisms

2002 ◽  
Vol 69 ◽  
pp. 117-134 ◽  
Author(s):  
Stuart M. Haslam ◽  
David Gems ◽  
Howard R. Morris ◽  
Anne Dell
Keyword(s):  
Caenorhabditis Elegans ◽  
Current Knowledge ◽  
Structural Data ◽  
Model Organisms ◽  
Entire Genome ◽  
C Elegans ◽  
The Face ◽  
Area Of Concern ◽  
Nematode Worm

There is no doubt that the immense amount of information that is being generated by the initial sequencing and secondary interrogation of various genomes will change the face of glycobiological research. However, a major area of concern is that detailed structural knowledge of the ultimate products of genes that are identified as being involved in glycoconjugate biosynthesis is still limited. This is illustrated clearly by the nematode worm Caenorhabditis elegans, which was the first multicellular organism to have its entire genome sequenced. To date, only limited structural data on the glycosylated molecules of this organism have been reported. Our laboratory is addressing this problem by performing detailed MS structural characterization of the N-linked glycans of C. elegans; high-mannose structures dominate, with only minor amounts of complex-type structures. Novel, highly fucosylated truncated structures are also present which are difucosylated on the proximal N-acetylglucosamine of the chitobiose core as well as containing unusual Fucα1–2Gal1–2Man as peripheral structures. The implications of these results in terms of the identification of ligands for genomically predicted lectins and potential glycosyltransferases are discussed in this chapter. Current knowledge on the glycomes of other model organisms such as Dictyostelium discoideum, Saccharomyces cerevisiae and Drosophila melanogaster is also discussed briefly.

A Relationship Between Thermotolerance and Longevity in Caenorhabditis elegans

1998 ◽  
Vol 3 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Glenda A Walker ◽  
David W Walker ◽  
Gordon J Lithgow
Keyword(s):  
Caenorhabditis Elegans
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