Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

10.3791/59223 ◽  
2019 ◽  
Author(s):  
Ravan Moret ◽  
Linh Hellmers ◽  
Xin Zhang ◽  
Jessie Gills ◽  
Nathan Hite ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Growth ◽  
Cell Carcinoma ◽  
Urothelial Cell ◽  
Urothelial Cell Carcinoma ◽  
Spontaneous Metastasis ◽  
Orthotopic Xenograft ◽  
Cancer Tumor ◽  
Human Urothelial Cell ◽  
Xenograft Models

scholarly journals Honokiol Is a Potential Therapeutic Agent and Has a Synergistic Effect With 5-FU in Human Urothelial Cell Carcinoma Cells

2019 ◽  
Vol 39 (12) ◽  
pp. 6555-6565 ◽  
Author(s):  
MING-YANG LEE ◽  
CHUNG-SHENG SHI ◽  
YEN-CHEN HSU ◽  
KAO-JEAN HUANG ◽  
SHU-HSIN CHEN ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Cell Carcinoma ◽  
Therapeutic Agent ◽  
Carcinoma Cells ◽  
Urothelial Cell ◽  
Urothelial Cell Carcinoma ◽  
Potential Therapeutic Agent ◽  
Human Urothelial Cell

Whorled Urothelial Cell Carcinoma

2014 ◽  
Vol 22 (5) ◽  
pp. 408-413
Author(s):  
Carlo Patriarca ◽  
Eva Comperat ◽  
Enrico Bollito ◽  
Agazio Ussia ◽  
Giovanni Scola ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Urothelial Cell ◽  
Urothelial Cell Carcinoma

scholarly journals Reactivation of BK Polyomavirus in Urine Cytology Is Not Associated with Urothelial Cell Carcinoma

Viruses ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1412
Author(s):  
Faisal Klufah ◽  
Ghalib Mobaraki ◽  
Axel zur Hausen ◽  
Iryna V. Samarska
Keyword(s):  
Cell Carcinoma ◽  
Urine Cytology ◽  
Urothelial Cell ◽  
The Other ◽  
Urothelial Cell Carcinoma ◽  
Tissue Samples ◽  
Bk Polyomavirus ◽  
Ffpe Tissues ◽  
Immunosuppressed Patients ◽  
History Of

BK polyomavirus (BKPyV) has been associated with some high-grade and special urothelial cell carcinoma (UCC) subtypes in immunosuppressed patients. Here, we evaluated the relationship of BKPyV-positive urine cytology specimens (UCS) with UCC. A large single-institution database was retrospectively searched for UCS positive for decoy cells, suggesting BKPyV infection. These were tested for the presence of BKPyV by PCR and immunohistochemistry (IHC) in urine sediments and formalin-fixed paraffin-embedded (FFPE) tissue samples of UCC. Decoy cells were reported in 30 patients out of the database with 22.867 UCS. Of these 30 patients, 16 (53.3%) had no history of UCC. Six patients out of these 16 had a history of transplantation, 4 had a history of severe chronic medical conditions, and 6 had no chronic disease. The other fourteen patients were diagnosed with either in situ or invasive UCC of the urinary bladder (14/30; 46.6%) prior to the detection of decoy cells in the urine. Nine of these UCC patients received intravesical treatment (BCG or mitomycin) after the first presentation with UCC. However, the clinical data on the treatment of the other five UCC patients was lacking. IHC identified BKPyV-positivity in the urine samples of non-UCC and UCC patients, while no BKPyV positivity was found in FFPE tissues of primary UCCs and metastases. In addition, BKPyV-PCR results revealed the presence of BKPyV DNA in the urine of the UCC cases, yet none in the UCC tissues itself. These data strongly indicate that BKPyV reactivation is not restricted to immunosuppression. It can be found in UCS of the immunocompetent patients and may be related to the intravesical BCG or mitomycin treatment of the UCC patients.

scholarly journals Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition

2012 ◽  
Vol 96 (4) ◽  
pp. 902-910 ◽  
Author(s):  
Martine M Ros ◽  
H Bas Bueno-de-Mesquita ◽  
Ellen Kampman ◽  
Katja KH Aben ◽  
Frederike L Büchner ◽  
...  
Keyword(s):  
Vitamin C ◽  
Cell Carcinoma ◽  
Urothelial Cell ◽  
Urothelial Cell Carcinoma ◽  
Prospective Investigation
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