Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

10.3791/58708 ◽  
2019 ◽  
Author(s):  
Jessica Lavier ◽  
Manon Beaumann ◽  
Steeve Ménetrey ◽  
Lucia Mazzolai ◽  
Anne-Christine Peyter ◽  
...  
Keyword(s):  
Vascular Function ◽  
Hypoxic Exercise ◽  
Function Assessment

scholarly journals Single passive leg movement-induced hyperemia: a simple vascular function assessment without a chronotropic response

2017 ◽  
Vol 122 (1) ◽  
pp. 28-37 ◽  
Author(s):  
Massimo Venturelli ◽  
Gwenael Layec ◽  
Joel Trinity ◽  
Corey R. Hart ◽  
Ryan M. Broxterman ◽  
...  
Keyword(s):  
Vascular Function ◽  
Knee Flexion ◽  
Assessment Method ◽  
Peripheral Stimulus ◽  
Clinical Role ◽  
Chronotropic Response ◽  
Novel Approach ◽  
Leg Movement ◽  
Flexion And Extension ◽  
Function Assessment

Passive leg movement (PLM)-induced hyperemia is a novel approach to assess vascular function, with a potential clinical role. However, in some instances, the varying chronotropic response induced by PLM has been proposed to be a potentially confounding factor. Therefore, we simplified and modified the PLM model to require just a single PLM (sPLM), an approach that may evoke a peripheral hemodynamic response, allowing a vascular function assessment, but at the same time minimizing central responses. To both characterize and assess the utility of sPLM, in 12 healthy subjects, we measured heart rate (HR), stroke volume, cardiac output (CO), mean arterial pressure (MAP), leg blood flow (LBF), and calculated leg vascular conductance (LVC) during both standard PLM, consisting of passive knee flexion and extension performed at 1 Hz for 60 s, and sPLM, consisting of only a single passive knee flexion and extension over 1 s. During PLM, MAP transiently decreased (5 ± 1 mmHg), whereas both HR and CO increased from baseline (6.0 ± 1.1 beats/min, and 0.8 ± 0.01 l/min, respectively). Following sPLM, MAP fell similarly (5 ± 2 mmHg; P = 0.8), but neither HR nor CO responses were identifiable. The peak LBF and LVC response was similar for PLM (993 ± 189 ml/min; 11.9 ± 1.5 ml·min−1·mmHg−1, respectively) and sPLM (878 ± 119 ml/min; 10.9 ± 1.6 ml·min−1·mmHg−1, respectively). Thus sPLM represents a variant of the PLM approach to assess vascular function that is more easily performed and evokes a peripheral stimulus that induces a significant hyperemia, but does not generate a potentially confounding, chronotropic response, which may make sPLM more useful clinically. NEW & NOTEWORTHY Using the single passive leg movement (PLM) technique, a variant of the vascular function assessment PLM, we have identified a novel peripheral vascular assessment method that is more easily performed than PLM, which, by not evoking potentially confounding central hemodynamic responses, may be more useful clinically.

Abstract 146: Relation Between Noninvasive Vascular Function Assessment Methods in Healthy and Obese Adults

Hypertension ◽  
2012 ◽  
Vol 60 (suppl_1) ◽  
Author(s):  
Kacie Dickinson ◽  
Peter Clifton ◽  
Jennifer Keogh
Keyword(s):  
Endothelial Function ◽  
Vascular Function ◽  
Augmentation Index ◽  
Applanation Tonometry ◽  
Obese Adults ◽  
Peripheral Arterial Tonometry ◽  
Cross Sectional ◽  
Bivariate Correlation ◽  
The Relationship ◽  
Function Assessment

Peripheral arterial tonometry (PAT) is a novel method of non-invasive endothelial function assessment. However the physiology underlying PAT and its relationship to established methods of assessment not clear. Therefore we evaluated the relationship between PAT in the digital microcirculation with an established method of ultrasound assessment of flow-mediated dilatation (FMD) in the brachial artery in a sample of healthy and obese subjects. We also compared the augmentation index (AIx) derived from PAT and compared this with AIx derived by radial applanation tonometry (SphygmoCor). Using a cross-sectional design 16 healthy individuals (age 36±16years; BMI 25±5kg/m 2 ) and 14 overweight and obese patients (age 57±7years; BMI 31±6kg/m 2 ) were examined. Vascular function was assessed using FMD and PAT techniques simultaneously after an overnight fast. 14 overweight subjects had augmentation index (AIx) assessed using radial applanation tonometry immediately prior to PAT and FMD procedures. Bivariate correlation analysis was used to assess the relationship between variables. No significant correlations between fasting FMD and PAT were observed in the healthy (r=0.249 p=0.372) or overweight and obese group (r=-0.345 p=0.227). There was no correlation between the endothelium-independent responses to nitroglycerin measured by PAT and brachial ultrasound (r=0.357 p=0.210). AIx derived from EndoPAT was significantly correlated with AIx values obtained with Sphygmocor (r=0.770 p=0.001). In conclusion AIx derived from SphygmoCor and EndoPAT were significantly correlated however PAT and FMD were not related in healthy or obese adults. This may be due to differing vascular biology of the PAT response to hyperaemia in the digital circulation compared with the FMD response measured in conduit vessels. PAT as a method of endothelial function assessment requires further validation in population sub groups.

Residual hepatic mitochondrial function assessment through 13C-methionine, 13C-octanoate and 13C-ketoisocaproate breath tests

2001 ◽  
Vol 120 (5) ◽  
pp. A566-A566
Author(s):  
A ARMUZZI ◽  
M ZOCCO ◽  
M CANDELLI ◽  
C DICAMPLI ◽  
E NISTA ◽  
...  
Keyword(s):  
Mitochondrial Function ◽  
Breath Tests ◽  
Function Assessment

1905: The Effect of Percutaneous Nephrolithotripsy (PCNL) on Renal Function: Assessment with Quantitative Spect of TC 99M-DMSA (QDMSA) Renal Scintigraphy

2004 ◽  
Vol 171 (4S) ◽  
pp. 503-503
Author(s):  
Boaz Moskovitz ◽  
Vladimir Sopov ◽  
Sarel Halachmi ◽  
Michael Mullerad ◽  
Yusef Barbara ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Scintigraphy ◽  
Quantitative Spect ◽  
Percutaneous Nephrolithotripsy ◽  
Function Assessment

The Relationship Between Anthropometric Indexes of Adiposity and Vascular Function in the FATE Cohort

Obesity ◽  
2012 ◽  
Author(s):  
Billie-Jean Martin ◽  
Subodh Verma ◽  
Francois Charbonneau ◽  
Lawrence M. Title ◽  
Eva M. Lonn ◽  
...  
Keyword(s):  
Vascular Function ◽  
Anthropometric Indexes ◽  
The Relationship
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