scholarly journals Real-time Pressure-volume Analysis of Acute Myocardial Infarction in Mice

Author(s):  
Lars Michel ◽  
Pia Stock ◽  
Christos Rammos ◽  
Matthias Totzeck ◽  
Tienush Rassaf ◽  
...  
1989 ◽  
Vol 8 (10) ◽  
pp. 52
Author(s):  
Mitchell W. Krucoff ◽  
Yvette R. Jackson ◽  
Deana L. Burdette ◽  
Rita A. Weber ◽  
Janice S. Stone ◽  
...  

Author(s):  
Divij Khetan

Background: In recent years, real time 3D echocardiography (RT3DE), a novel and non-invasive method has catched the eyes of various cardiologists for evaluating ventricular dyssynchrony. The main aim of the present study was to establish applicability of RT3DE for the assessment of ventricular dyssynchrony in patients with dilated cardiomyopathy (DCMP) and acute myocardial infarction (AMI).Methods: It was a hospital based observational and comparative study which included total 105 patients. Among all the patients, 35 with DCMP, 35 with AMI and 35 healthy patients were included. Various electrocardiographic, 2D and 3D echocardiography parameters were evaluated. Percentage ventricular systolic dyssynchrony index (SDI) was estimated using RT3DE to define ventricular dyssynchrony. The correlation of SDI with left ventricular ejection fraction (LVEF) and QRS duration of all patients was calculated using Pearson correlation co-efficient and regression equation.Results: Age distribution among all three groups was non-significant with mean age 53.56±12.11 years. The RT3DE displayed significantly higher SDI (p=0.001) in DCMP group (16.67±5.81 %) followed by AMI group (8.6±2.2%) and control group (3.14±1.0%). The value of QRS duration was also higher (>140ms) in DCMP patients (142.40±34.71ms) and lower (>120ms) in AMI (108.85±20.67ms) and healthy patients (91.08±8.88ms). No significant correlation of SDI with LVEF among all three groups was observed.Conclusions: The results added more practicality of RT3DE for estimation of ventricular dyssynchrony in patients with varied cardiac conditions and also displayed its utility as an appropriate guide for cardiac resynchronization therapy.


Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Hiroshi Nonogi ◽  
Hiroyuki Yokoyama ◽  
Yoritaka Otsuka ◽  
Yoichiro Kasahara ◽  
Yu Kataoka ◽  
...  

[Purpose] AHA/ACC guidelines recommend routine use of 12-lead ECG and advance notification for patients with acute coronary syndrome. However, transmission of out-of-hospital 12-lead ECG to emergency department is still not spread and ECG interpretation on the prehospital and emergency department is not established. Therefore, we have developed and tested the clinical usefulness of the mobile telemedicine system to transmit 12-lead ECG between moving ambulances and physicians in cardiovascular emergency. [Method] We set up the mobile telemedicine using the third-generation digital mobile phone to promote communications between an ambulance and diverse hospital. Compatibility issue among device vendors was solved by the implementation of open-standard medical waveform encoding rule with motion noise-reduction system. Real time 12-lead ECG was transferred together with vital signs and live video during transfer the patient by an ambulance. The performance of the mobile telemedicine system in the field-test was checked to transfer 12-lead ECG in different scenarios such as transferred ECG from a volunteer moving hand or leg, coughing or twisting body in an ambulance driving on common road or highway. In the next step, we set up the mobile telemedicine on an ambulance to promote communications between moving 5 ambulances in Suita-city and National Cardiovascular Center since 2008 June 2. To establish the efficacy of real-time transmission of out-of-hospital 12-lead ECG, the time-line from the onset of acute myocardial infarction to reperfusion is analyzed. [Results] Totally 36 patters of 12-lead ECG were checked in the field test and all of them were comparable than those original one in the ambulance. Time-delay for transmission of 12 lead ECG was within 10seconds and for one-lead ECG monitoring and vital signs including BP, HR and oxygen saturation was 1 second without the difficulties for the interpretation. [Conclusion] Those results indicate the usefulness and reliability of transmission of 12-lead ECG using the mobile telemedicine system from the ambulance. Further investigation is on-going to determine the efficacy in clinical conditions to reduce the treatment delay for acute myocardial infarction.


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