Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice

10.3791/57570 ◽  
2020 ◽  
Author(s):  
Akihiro Fukushima ◽  
Moeko Fujii ◽  
Hideki Ono
Keyword(s):  
Pain Tests

Reference values of mechanical and thermal pain tests in a pain-free population

2011 ◽  
Vol 15 (4) ◽  
pp. 376-383 ◽  
Author(s):  
Alban Y. Neziril ◽  
Pasquale Scaramozzinol ◽  
Ole K. Andersenl ◽  
Anthony H. Dickensonl ◽  
Lars Arendt-Nielsenl ◽  
...  
Keyword(s):  
Reference Values ◽  
Thermal Pain ◽  
Pain Tests

Comparison of Five Experimental Pain Tests to Measure Analgesic Effects of Alfentanil

2001 ◽  
Vol 95 (1) ◽  
pp. 22-29 ◽  
Author(s):  
Martin Luginbühl ◽  
Thomas W. Schnider ◽  
Steen Petersen-Felix ◽  
Lars Arendt-Nielsen ◽  
Alex M. Zbinden
Keyword(s):  
Response Curve ◽  
Plasma Concentrations ◽  
Experimental Pain ◽  
Pain Tolerance ◽  
Time Effect ◽  
Intraindividual Variation ◽  
Pressure Pain ◽  
Pain Tests ◽  
Ice Water ◽  
Concentration Response Curve

Background Several experimental pain models have been used to measure opioid effects in humans. The aim of the current study was to compare the qualities of five frequently used experimental pain tests to measure opioid effects. Methods The increase of electrical, heat, and pressure pain tolerance and the decrease of ice-water and ischemic pain perception was determined at baseline and at four different plasma concentrations of alfentanil (n = 7) administered as target controlled infusion or placebo (n = 7). A linear mixed-effects modeling (NONMEM) was performed to detect drug, placebo, and time effect as well as interindividual and intraindividual variation of effect. Results Only the electrical, ice-water, and pressure pain tests are sensitive to assess a concentration-response curve of alfentanil. At a plasma alfentanil concentration of 100 ng/ml, the increase in pain tolerance compared with baseline was 42.0% for electrical pain, 22.2% for pressure pain, and 21.7% for ice-water pain. The slope of the linear concentration-response curve had an interindividual coefficient of variation of 58.3% in electrical pain, 35.6% in pressure pain, and 60.0% in ice-water pain. The residual error including intraindividual variation at an alfentanil concentration of 100 ng/ml was 19.4% for electrical pain, 6.1% for pressure pain, and 13.0% for ice-water pain. Electrical pain was affected by a significant placebo effect, and pressure pain was affected by a significant time effect. Conclusion Electrical, pressure, and ice-water pain, but not ischemic and heat pain, provide significant concentration-response curves in the clinically relevant range of 200 ng/ml alfentanil or lower. The power to detect a clinically relevant shift of the curve is similar in the three tests. The appropriate test(s) for pharmacodynamic studies should be chosen according to the investigated drug(s) and the study design.

Stimulation-produced analgesia in rats: Assessment by two pain tests and correlation with self-stimulation

1980 ◽  
Vol 68 (2) ◽  
pp. 295-309 ◽  
Author(s):  
Stephen G. Dennis ◽  
Manon Choinière ◽  
Ronald Melzack
Keyword(s):  
Pain Tests ◽  
Self Stimulation

Comparative effects of different uptake inhibitor antidepressants in two pain tests in mice

1992 ◽  
Vol 6 (2) ◽  
pp. 75-82 ◽  
Author(s):  
D. Ardid ◽  
H. Marty ◽  
J. Fialip ◽  
AM Privat ◽  
A. Eschalier ◽  
...  
Keyword(s):  
Uptake Inhibitor ◽  
Pain Tests

Antinociceptive effects of the novel anxiolytic buspirone in three pain tests in rats

Pain ◽  
1989 ◽  
Vol 39 (1) ◽  
pp. 109-113 ◽  
Author(s):  
James Giordano ◽  
LaVerne Rogers
Keyword(s):  
The Novel ◽  
Antinociceptive Effects ◽  
Pain Tests

scholarly journals Reliability of four experimental mechanical pain tests in children

2013 ◽  
pp. 103 ◽  
Author(s):  
Ann-Britt Langager Soee ◽  
Thomsen ◽  
Liselotte Skov ◽  
Birte Tornøe
Keyword(s):  
Pain Tests
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