scholarly journals Combining Microfluidics and Microrheology to Determine Rheological Properties of Soft Matter during Repeated Phase Transitions

10.3791/57429 ◽  
2018 ◽  
Author(s):  
Matthew D. Wehrman ◽  
Melissa J. Milstrey ◽  
Seth Lindberg ◽  
Kelly M. Schultz
Keyword(s):  
Phase Transitions ◽  
Rheological Properties ◽  
Soft Matter

Using μ2rheology to quantify rheological properties during repeated reversible phase transitions of soft matter

Lab on a Chip ◽  
2017 ◽  
Vol 17 (12) ◽  
pp. 2085-2094 ◽  
Author(s):  
Matthew D. Wehrman ◽  
Melissa J. Milstrey ◽  
Seth Lindberg ◽  
Kelly M. Schultz
Keyword(s):  
Phase Transitions ◽  
Rheological Properties ◽  
Soft Matter ◽  
Single Sample ◽  
Fluid Exchange ◽  
Reversible Phase ◽  
Surrounding Fluid

A novel microfluidic design enables repeated phase transitions in a single sample by surrounding fluid exchange and microrheological characterization.

Physical Principles Underlying the Complex Biology of Intracellular Phase Transitions

2020 ◽  
Vol 49 (1) ◽  
pp. 107-133 ◽  
Author(s):  
Jeong-Mo Choi ◽  
Alex S. Holehouse ◽  
Rohit V. Pappu
Keyword(s):  
Phase Transitions ◽  
Rheological Properties ◽  
Recent Work ◽  
Driving Forces ◽  
Rna Molecules ◽  
Associative Polymers ◽  
Different Types ◽  
Condensate Formation ◽  
The Impact ◽  
Physical Principles

Many biomolecular condensates appear to form via spontaneous or driven processes that have the hallmarks of intracellular phase transitions. This suggests that a common underlying physical framework might govern the formation of functionally and compositionally unrelated biomolecular condensates. In this review, we summarize recent work that leverages a stickers-and-spacers framework adapted from the field of associative polymers for understanding how multivalent protein and RNA molecules drive phase transitions that give rise to biomolecular condensates. We discuss how the valence of stickers impacts the driving forces for condensate formation and elaborate on how stickers can be distinguished from spacers in different contexts. We touch on the impact of sticker- and spacer-mediated interactions on the rheological properties of condensates and show how the model can be mapped to known drivers of different types of biomolecular condensates.

scholarly journals Defect-Mediated Phase Transitions in Active Soft Matter

2014 ◽  
Vol 112 (16) ◽  
Author(s):  
Christoph A. Weber ◽  
Christopher Bock ◽  
Erwin Frey
Keyword(s):  
Phase Transitions ◽  
Soft Matter

Rheological properties and the mechanical signatures of phase transitions in weakly-segregated rod-coil block copolymers

Soft Matter ◽  
2009 ◽  
Vol 5 (12) ◽  
pp. 2453 ◽  
Author(s):  
Bradley D. Olsen ◽  
Nerayo P. Teclemariam ◽  
Susan J. Muller ◽  
Rachel A. Segalman
Keyword(s):  
Phase Transitions ◽  
Block Copolymers ◽  
Rheological Properties

scholarly journals Phase Transitions in Soft Matter Induced by Selective Solvation

2011 ◽  
Vol 84 (6) ◽  
pp. 569-587 ◽  
Author(s):  
Akira Onuki ◽  
Ryuichi Okamoto ◽  
Takeaki Araki
Keyword(s):  
Phase Transitions ◽  
Soft Matter ◽  
Selective Solvation

Rheological properties of phase transitions in polydisperse and monodisperse colloidal rod systems

AIChE Journal ◽  
2021 ◽  
Author(s):  
Shiqin He ◽  
Dominic R. Pascucci ◽  
Marco Caggioni ◽  
Seth Lindberg ◽  
Kelly M. Schultz
Keyword(s):  
Phase Transitions ◽  
Rheological Properties

High Pressure X-ray Studies of Lipid Membranes and Lipid Phase Transitions

2014 ◽  
Vol 228 (10-12) ◽  
Author(s):  
Nicholas J. Brooks ◽  
John M. Seddon
Keyword(s):  
High Pressure ◽  
Phase Transitions ◽  
Lipid Membranes ◽  
Soft Matter ◽  
Lipid Membrane ◽  
Lipid Phase ◽  
Pressure Jump ◽  
X Ray ◽  
Lipid Phase Transitions ◽  
X Ray Scattering

AbstractHydrostatic pressure has dramatic effects on biomembrane structure and stability and is a key thermodynamic parameter in the context of the biology of deep sea organisms. Furthermore, high-pressure and pressure-jump studies are very useful tools in biophysics and biotechnology, where they can be used to study the mechanism and kinetics of lipid phase transitions, biomolecular transformations, and protein folding/unfolding. Here, we first give an overview of the technology currently available for X-ray scattering studies of soft matter systems under pressure. We then illustrate the use of this technology to study a variety of lipid membrane systems.

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