scholarly journals Visualizing the Interrenal Steroidogenic Tissue and Its Vascular Microenvironment in Zebrafish

10.3791/54820 ◽  
2016 ◽  
Author(s):  
Chih-Wei Chou ◽  
Jamie Lin ◽  
Hsin-Yu Hou ◽  
Yi-Wen Liu
Keyword(s):  
Steroidogenic Tissue

Ovarian granulosa cells are a viable source of iPSCs with the capacity for epigenetically-biased differentiation into steroidogenic tissue of the ovary

2013 ◽  
Vol 100 (3) ◽  
pp. S454
Author(s):  
R.M. Anchan ◽  
B. Gerami-Naini ◽  
J. Lindsey ◽  
S. Lipskind ◽  
S.Z. Williams ◽  
...  
Keyword(s):  
Granulosa Cells ◽  
Ovarian Granulosa Cells ◽  
Steroidogenic Tissue

Comparative morphology of the adrenal gland in selected species of the genus Podarcis

1991 ◽  
Vol 12 (2) ◽  
pp. 153-160 ◽  
Author(s):  
V. Laforgia ◽  
A. Capaldo ◽  
L. Varano ◽  
A. Cavagnuolo ◽  
R. Putti
Keyword(s):  
Adrenal Gland ◽  
Comparative Morphology ◽  
Cell Ratio ◽  
A Cells ◽  
A Cell ◽  
Steroidogenic Tissue ◽  
The Relationship

AbstractThe morphology of the adrenal gland and relationships between noradrenalin (NA) and adrenalin (A) cells were studied in selected species of the genus Podarcis. As in other previously-studied genera, the morphology of the adrenal gland is not homogeneous, and the species examined can be divided into two groups according to the relationship between chromaffin and steroidogenic tissue. Podarcis taurica and P. hispanica, in which the two tissues are strongly separated, belong to one group. P. wagleriana, P. muralis, P. sicula, P. pelofionnesiaca and P. melisellensis belong to a second group in which dorsal chromaffin ribbons send digitations between the steroidogenic cords. The NA/A cell ratio is higher in species of the first group than in those of the second.

THE DEVELOPMENT OF ADRENOCORTICOTROPHIN-SENSITIVE ADENYLATE CYCLASE ACTIVITY IN THE FOETAL RABBIT ADRENAL: A CORRELATED BIOCHEMICAL AND MORPHOLOGICAL STUDY

1976 ◽  
Vol 71 (3) ◽  
pp. 333-341 ◽  
Author(s):  
JANET D. M. ALBANO ◽  
PATRICIA M. JACK ◽  
TERESA JOSEPH ◽  
R. P. GOULD ◽  
P. W. NATHANIELSZ ◽  
...  
Keyword(s):  
Adenylate Cyclase ◽  
Morphological Changes ◽  
Smooth Endoplasmic Reticulum ◽  
Major Change ◽  
Cyclase Activity ◽  
Adenylate Cyclase Activity ◽  
Steroidogenic Enzymes ◽  
Ultrastructural Studies ◽  
Steroidogenic Tissue ◽  
Lamellar Type

SUMMARY Proliferation of the smooth endoplasmic reticulum, the site of some hydroxylating steroidogenic enzymes in foetal adrenocortical cells, is the first major change in the process of their differentiation into steroidogenic tissue. This was observed in our ultrastructural studies on foetal rabbit adrenals to begin at about day 19 of development. Morphological changes in the mitochondria, the site of production of other steroidogenic enzymes, occurred at about day 24. The elongated or rod-shaped forms of the earlier stages became flattened and rounded by this time, while the cristae were transformed from a flattened lamellar type of the earlier stages to the tubulo-vesicular form of the adult. Other changes observed included an increase in microvilli and in cell size, with a concomitant increase in thickness of the gland. Adenylate cyclase activity in foetal adrenal homogenates was assessed in response to sodium fluoride (NaF) and ACTH. All preparations responded to NaF. While good responses to ACTH were observed at days 24, 27, 28 and in the neonate, there was a lack of any significant response in the day 19 gland. Foetal ACTH was depressed by administration of cortisol, and the effects of this treatment on both the morphological changes and adenylate cyclase activity was reassessed. The response of foetal adrenals to ACTH was depressed by this treatment and differentiation of the mitochondria was arrested. These results suggest a circumscribed period for the development of ACTH-sensitive adenylate cyclase coinciding with the time at which final differentiation of the mitochondria is completed. Furthermore, both the differentiation of the mitochondria and the development of ACTH-sensitive adenylate cyclase in the foetal adrenal may be dependent on foetal ACTH secretion.

scholarly journals Human Skin is a Steroidogenic Tissue: Steroidogenic Enzymes and Cofactors Are Expressed in Epidermis, Normal Sebocytes, and an Immortalized Sebocyte Cell Line (SEB-1)

2003 ◽  
Vol 120 (6) ◽  
pp. 905-914 ◽  
Author(s):  
Diane Thiboutot ◽  
Kathyrn Gilliland ◽  
Zhaoyuan Cong ◽  
Sami Jabara ◽  
Jan M. McAllister ◽  
...  
Keyword(s):  
Cell Line ◽  
Human Skin ◽  
Steroidogenic Enzymes ◽  
Steroidogenic Tissue

scholarly journals Stimulation of pregnenolone metabolism and aromatase activity by luteinizing hormone in mouse uterus

2000 ◽  
pp. 799-807 ◽  
Author(s):  
S Debnath ◽  
D Mukherjee ◽  
SP Bhattachryya
Keyword(s):  
Luteinizing Hormone ◽  
High Performance ◽  
Aromatase Activity ◽  
Dependent Manner ◽  
Uterine Tissue ◽  
Mouse Uterus ◽  
In Vitro Effects ◽  
Steroidogenic Tissue ◽  
Stimulation Of

In vitro metabolism of pregnenolone (P5) as well as production of 17beta-estradiol (E2) were studied in uteri of untreated and luteinizing hormone (LH)-treated mice that had been ovariectomized (OVX) at late-diestrus stage. In the uteri of untreated mice, [H]pregnenolone was shown to be metabolized to Delta-components such as 17alpha-hydroxypregnenolone (17alpha-P5) and dehydroepiandrosterone (DHEA), whereas LH treatment resulted in significant increases in the formation of progesterone (P4), 17alpha-hydroxyprogesterone (17alpha-P4), androstenedione (AD) and testosterone (T). This was assessed by thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC). The content and release of P4 was shown to be stimulated by LH. Trilostane, an inhibitor of 3beta-hydroxysteroid dehydrogenase (3beta-HSD), inhibited LH-induced P4 synthesis and its release in a dose-dependent manner. A considerable increase in [H]estradiol formation from [H]testosterone was recorded in LH-stimulated uterine tissue as compared with the control, indicating the stimulatory effect of LH on aromatase activity. LH-stimulation in the synthesis of P4 and E2 in OVX mouse uteri was mimicked by dbcAMP (cell-permeable cAMP). Incubation with LH was shown to augment the conversion of P4 to various delta-3-oxosteroids. In vitro effects of LH on the synthesis and metabolism of P4, as well as on the stimulation of aromatase activity, were more pronounced in the uterine tissue of LH-primed OVX mice. Thus the results of the present study indicate that, under specific conditions, the uterus of the mouse behaves like steroidogenic tissue. Its prompt response to LH reveals the probable physiological relevance of the existence of LH receptors of high binding affinity in the uterine tissue of the mouse, as reported earlier.

Further Observations on the Relationships between the SCO and the Adrenal Gland of Lacerta s. sicula Raf.: Effects of Oestrogen Administration during Summer1

1985 ◽  
Vol 6 (3) ◽  
pp. 229-240 ◽  
Author(s):  
A. Ciarletta ◽  
V. D'Uva ◽  
L. Varano ◽  
V. Laforgia
Keyword(s):  
Adrenal Gland ◽  
Blood Vessels ◽  
Subsequent Treatment ◽  
Interstitial Tissue ◽  
Secretory Material ◽  
Oestrogen Treatment ◽  
Interrenal Cells ◽  
Steroidogenic Tissue

AbstractIn order to verify the relationships between the SCO and the adrenal, specimens of Lacerta s. sicula were treated with oestrogens during summer, when the adrenal is very active and the SCO cells are filled with secretory material. After oestrogen treatment the interrenal cells appear reduced in size and large blood vessels appear between the interrenal cords. The SCO cells during the first period of treatment show a clear decrease in the amount of secretory material; subsequent treatment restores the levels of secretory material in the SCO cells cytoplasm, which shows an appearance identical to that exhibited by the control specimens of the same period. The results of these experiments point out that adrenal steroidogenic tissue is affected by the action of oestrogen, whose administration causes inactivation of the interrenal tissue with consequences on the SCO activity confirming the existence of a relationship between adrenal gland, interstitial tissue of the testis and SCO, already pointed out by preceding studies carried out in our laboratory.

Sign in / Sign up

Export Citation Format

Share Document