A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice

The Microbead Occlusion Model of Ocular Hypertension in Mice

Glaucoma - Methods in Molecular Biology ◽

10.1007/978-1-4939-7407-8_3 ◽

2017 ◽

pp. 23-39 ◽

Cited By ~ 11

Author(s):

David J. Calkins ◽

Wendi S. Lambert ◽

Cathryn R. Formichella ◽

William M. McLaughlin ◽

Rebecca M. Sappington

Keyword(s):

Ocular Hypertension ◽

Occlusion Model

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The Microbead Occlusion Model: A Paradigm for Induced Ocular Hypertension in Rats and Mice

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.09-3947 ◽

2010 ◽

Vol 51 (1) ◽

pp. 207 ◽

Cited By ~ 166

Author(s):

Rebecca M. Sappington ◽

Brian J. Carlson ◽

Samuel D. Crish ◽

David J. Calkins

Keyword(s):

Ocular Hypertension ◽

Occlusion Model ◽

Rats And Mice

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Correlation of Angiographic Coronary Anatomy With Tc99m Sestamibi SPECT Imaging Using a Balloon Occlusion Model in Patients Undergoing Coronary Angioplasty

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)87914-4 ◽

1998 ◽

Vol 31 (2) ◽

pp. 441A

Author(s):

D Fram

Keyword(s):

Coronary Angioplasty ◽

Balloon Occlusion ◽

Spect Imaging ◽

Coronary Anatomy ◽

Occlusion Model

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IOP Lowering Effects of Ocimum basilicum Seed Extract in Two Rabbit Models of Ocular Hypertension

Journal of Clinical and Health Sciences ◽

10.24191/jchs.v4i1.7281 ◽

2019 ◽

Vol 4 (1) ◽

pp. 39

Author(s):

Renu Agarwal ◽

SK Gupta ◽

Sushma Srivastava ◽

Rohit Saxena

Keyword(s):

Ocular Hypertension ◽

Antioxidant Properties ◽

Ocimum Basilicum ◽

Seed Extract ◽

Water Loading ◽

Antiglaucoma Medication ◽

Lowering Effect ◽

Significant Difference ◽

The Mean ◽

And Control

Introduction: Ocimum basilicum (OB), a herb known for its antihypertensive, anticholinesterase and antioxidant properties was investigated for possible intraocular pressure (IOP) lowering effects in rabbits with ocular hypertension (OHT). Methods: The IOP lowering effect of a single drop of OB extract (OBE) was evaluated in oculonormotensive rabbits using three concentrations (0.25, 0.5 and 1% w/v). The concentration showing maximum IOP reduction was further evaluated in rabbits with water-loading and steroid-induced OHT. Results: IOP lowering effect of OBE 0.5% in oculonormotensive rabbit eyes was significantly greater compared to OBE 0.25% (p<0.05) but was comparable (p>0.05) to OBE 1%. Therefore, 0.5% concentration was selected for further evaluation. Pretreatment with OBE (0.5%) caused significantly lower increase in IOP after water loading amounting to 23.39% above baseline as compared to 54.00% in control eye, 15 minutes post water loading. At 60 minutes, post water loading, mean IOP rise was 95.12% and 63.58% in control and test eyes, respectively. Significant difference between the mean IOP of two eyes persisted during the 2nd hr. In rabbits with steroid induced OHT, OBE 0.5% produced a mean IOP reduction of 24.73% at the end of first hr and the mean peak IOP reduction of 31.63% was observed at the end of 2 hr. A significant difference between the IOP of test and control eyes persisted from 1 to 6 hr. Conclusions: Ocimum basilicum seed extract showed significant IOP lowering effect in rabbits with water loading and steroid induced OHT, however, its utility as an effective antiglaucoma medication needs further investigations.

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