scholarly journals Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

10.3791/52415 ◽  
2015 ◽  
Author(s):  
Aliya Gifford ◽  
Theodore F. Towse ◽  
Ronald C. Walker ◽  
Malcolm J. Avison ◽  
E. Brian Welch
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Adipose Tissue ◽  
Magnetic Resonance ◽  
Brown Adipose Tissue ◽  
Magnetic Resonance Images ◽  
Emission Tomography ◽  
Adipose Tissue Depots ◽  
Positron Emission ◽  
Brown Adipose

Recent advances in the detection of brown adipose tissue in adult humans: a review

2018 ◽  
Vol 132 (10) ◽  
pp. 1039-1054 ◽  
Author(s):  
Frank J. Ong ◽  
Basma A. Ahmed ◽  
Stephan M. Oreskovich ◽  
Denis P. Blondin ◽  
Tahniyah Haq ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Metabolic Activity ◽  
Cold Exposure ◽  
Emission Tomography ◽  
Positron Emission ◽  
Brown Adipose ◽  
Pet Ct

The activation of brown adipose tissue (BAT) is associated with reductions in circulating lipids and glucose in rodents and contributes to energy expenditure in humans indicating the potential therapeutic importance of targetting this tissue for the treatment of a variety of metabolic disorders. In order to evaluate the therapeutic potential of human BAT, a variety of methodologies for assessing the volume and metabolic activity of BAT are utilized. Cold exposure is often utilized to increase BAT activity but inconsistencies in the characteristics of the exposure protocols make it challenging to compare findings. The metabolic activity of BAT in response to cold exposure has most commonly been measured by static positron emission tomography of 18F-fluorodeoxyglucose in combination with computed tomography (18F-FDG PET-CT) imaging, but recent studies suggest that under some conditions this may not always reflect BAT thermogenic activity. Therefore, recent studies have used alternative positron emission tomography and computed tomography (PET-CT) imaging strategies and radiotracers that may offer important insights. In addition to PET-CT, there are numerous emerging techniques that may have utility for assessing BAT metabolic activity including magnetic resonance imaging (MRI), skin temperature measurements, near-infrared spectroscopy (NIRS) and contrast ultrasound (CU). In this review, we discuss and critically evaluate the various methodologies used to measure BAT metabolic activity in humans and provide a contemporary assessment of protocols which may be useful in interpreting research findings and guiding the development of future studies.

scholarly journals Repeatability of Quantitative Brown Adipose Tissue Imaging Metrics on Positron Emission Tomography with 18F-Fluorodeoxyglucose in Humans

2019 ◽  
Vol 30 (1) ◽  
pp. 212-224.e4 ◽  
Author(s):  
Tyler J. Fraum ◽  
John P. Crandall ◽  
Daniel R. Ludwig ◽  
Sihao Chen ◽  
Kathryn J. Fowler ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Emission Tomography ◽  
Tissue Imaging ◽  
18F Fluorodeoxyglucose ◽  
Positron Emission ◽  
Brown Adipose
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