scholarly journals 3-Dimensional Resin Casting and Imaging of Mouse Portal Vein or Intrahepatic Bile Duct System

10.3791/4272 ◽  
2012 ◽  
Author(s):  
Teagan J. Walter ◽  
Erin E. Sparks ◽  
Stacey S. Huppert
Keyword(s):  
Bile Duct ◽  
Portal Vein ◽  
Intrahepatic Bile Duct ◽  
Duct System ◽  
3 Dimensional ◽  
Bile Duct System

scholarly journals Cholangiogenic potential of human deciduous pulp stem cell-converted hepatocyte-like cells

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Ratih Yuniartha ◽  
Takayoshi Yamaza ◽  
Soichiro Sonoda ◽  
Koichiro Yoshimaru ◽  
Toshiharu Matsuura ◽  
...  
Keyword(s):  
Bile Duct ◽  
Liver Fibrosis ◽  
Intrahepatic Bile Duct ◽  
Duct System ◽  
Hepatic Differentiation ◽  
Fibrotic Liver ◽  
Bile Duct System ◽  
Recipient Liver ◽  
Stimulation Of

Abstract Background Stem cells from human exfoliated deciduous teeth (SHED) have been reported to show the in vivo and in vitro hepatic differentiation, SHED-Heps; however, the cholangiogenic potency of SHED-Heps remains unclear. Here, we hypothesized that SHED-Heps contribute to the regeneration of intrahepatic bile duct system in chronic fibrotic liver. Methods SHED were induced into SHED-Heps under cytokine stimulation. SHED-Heps were intrasplenically transplanted into chronically CCl4-treated liver fibrosis model mice, followed by the analysis of donor integration and hepatobiliary metabolism in vivo. Immunohistochemical assay was examined for the regeneration of intrahepatic bile duct system in the recipient liver. Furthermore, SHED-Heps were induced under the stimulation of tumor necrosis factor alpha (TNFA). Results The intrasplenic transplantation of SHED-Heps into CCl4-treated mice showed that donor SHED-Heps behaved as human hepatocyte paraffin 1- and human albumin-expressing hepatocyte-like cells in situ and ameliorated CCl4-induced liver fibrosis. Of interest, the integrated SHED-Heps not only expressed biliary canaliculi ATP-binding cassette transporters including ABCB1, ABCB11, and ABCC2, but also recruited human keratin 19- (KRT19-) and KRT17-positive cells, which are considered donor-derived cholangiocytes, regenerating the intrahepatic bile duct system in the recipient liver. Furthermore, the stimulation of TNFA induced SHED-Heps into KRT7- and SRY-box 9-positive cells. Conclusions Collectively, our findings demonstrate that infused SHED-Heps showed cholangiogenic ability under the stimulation of TNFA in CCl4-damaged livers, resulting in the regeneration of biliary canaliculi and interlobular bile ducts in chronic fibrotic liver. Thus, the present findings suggest that SHED-Heps may be a novel source for the treatment of cholangiopathy.

Distortion in TGFβ1 peptide immunolocalization in biliary atresia: Comparison with the normal pattern in the developing human intrahepatic bile duct system

1995 ◽  
Vol 45 (11) ◽  
pp. 815-824 ◽  
Author(s):  
Carolyn E. L. Tan ◽  
Vivian S. W. Chan ◽  
Rita Y. Y. Yong ◽  
Vijayalaxmy Vijayan ◽  
Wan L. Tan ◽  
...  
Keyword(s):  
Bile Duct ◽  
Biliary Atresia ◽  
Intrahepatic Bile Duct ◽  
Duct System ◽  
Normal Pattern ◽  
Bile Duct System

scholarly journals Ascending Cholangitis due to Heavy Lifting

2017 ◽  
Vol 11 (2) ◽  
pp. 500-503
Author(s):  
M.J. Bakkum ◽  
R.J.L.F. Loffeld
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Gallstone Disease ◽  
Duct System ◽  
Common Risk Factor ◽  
Present Case Report ◽  
Curative Therapy ◽  
Bile Duct System ◽  
Duodenal Reflux ◽  
The Common

Gallstone disease is the most common risk factor for cholangitis. In an anatomically normal bile duct system, cholangitis does not occur without the presence of stones. Endoscopic retrograde cholangiography with papillotomy and stone extraction is a well-established curative therapy for gallstones in the common bile duct. More important, papillotomy prevents recurrent episodes. The present case report describes a 73-year-old male with recurring cholangitis in a clear bile duct system after previous papillotomy. An etiology of duodenal reflux into the common bile duct due to heavy lifting is proposed.

SURGICAL ASPECTS OF LIVER DISEASE

PEDIATRICS ◽  
1955 ◽  
Vol 16 (1) ◽  
pp. 135-137
Author(s):  
Orvar Swenson ◽  
John Herbert Fisher
Keyword(s):  
Liver Disease ◽  
Bile Duct ◽  
Obstructive Jaundice ◽  
Duct System ◽  
Congenital Atresia ◽  
Surgical Exploration ◽  
Bile Duct System ◽  
Surgical Aspects ◽  
Prolonged Jaundice

IN THE care of infants with prolonged jaundice, the surgeon is particularly concerned with those suspected of having obstruction of the extrahepatic ducts. In 1927, Ladd was the first to correct successfully congenital atresia of the bile duct system. At that time, and for some time afterwards, there was great enthusiasm and hope that a considerable number of infants with signs of obstructive jaundice could be helped. Unfortunately, events have not proved this to be so. According to various reports, only 2 to 3 per cent of infants with clinical obstructive jaundice prove to have an atresia of the extrahepatic duct system which is amenable to surgery. To select these few patients who have atresia of the extrahepatic duct out of the large number of jaundiced infants is a difficult task. Formerly, it was common practice to subject all these infants to extensive surgical exploration at 6 to 8 weeks of age to be sure that no correctable lesion was overlooked. Gellis was the first to call attention to the fact that these explorations, particularly in infants under 3 months, were not without hazard. Among the cases he reviewed there were some deaths directly attributable to the diagnostic explorations. Consequently, it has become common practice to delay exploration on these infants until they are 5 to 6 months of age. This practice seems reasonable to circumvent the problem of deaths after exploration, for this hazard is a great deal less after the infants are 6 months or more of age.

scholarly journals Histochemical Study on the Bile Duct System of Normal Rats

1990 ◽  
Vol 39 (3) ◽  
pp. 421-424
Author(s):  
Shin-ichi ITAGAKI ◽  
Chiyo DOI ◽  
Tomotari MITSUOKA ◽  
Kunio DOI
Keyword(s):  
Bile Duct ◽  
Histochemical Study ◽  
Duct System ◽  
Bile Duct System

The Bile Duct System and its Anatomical Variations

Endoscopy ◽  
1989 ◽  
Vol 21 (S 1) ◽  
pp. 300-308 ◽  
Author(s):  
K. Charels ◽  
G. Klöppel
Keyword(s):  
Bile Duct ◽  
Anatomical Variations ◽  
Duct System ◽  
Bile Duct System

scholarly journals Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome

Development ◽  
2010 ◽  
Vol 137 (23) ◽  
pp. 4061-4072 ◽  
Author(s):  
J. J. Hofmann ◽  
A. C. Zovein ◽  
H. Koh ◽  
F. Radtke ◽  
G. Weinmaster ◽  
...  
Keyword(s):  
Bile Duct ◽  
Portal Vein ◽  
Intrahepatic Bile Duct ◽  
Alagille Syndrome ◽  
Duct Development
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