scholarly journals Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution

10.3791/4161 ◽  
2012 ◽  
Author(s):  
Serhan O. Isikman ◽  
Waheb Bishara ◽  
Aydogan Ozcan
Keyword(s):  
Super Resolution ◽  
On Chip

Wavelength scanning achieves pixel super-resolution in holographic on-chip microscopy

2016 ◽  
Author(s):  
Wei Luo ◽  
Zoltan Göröcs ◽  
Yibo Zhang ◽  
Alborz Feizi ◽  
Alon Greenbaum ◽  
...  
Keyword(s):  
Super Resolution ◽  
Wavelength Scanning ◽  
On Chip

scholarly journals Holographic pixel super-resolution in portable lensless on-chip microscopy using a fiber-optic array

Lab on a Chip ◽  
2011 ◽  
Vol 11 (7) ◽  
pp. 1276 ◽  
Author(s):  
Waheb Bishara ◽  
Uzair Sikora ◽  
Onur Mudanyali ◽  
Ting-Wei Su ◽  
Oguzhan Yaglidere ◽  
...  
Keyword(s):  
Fiber Optic ◽  
Super Resolution ◽  
On Chip ◽  
Optic Array

Nanosecond Pulsed Electric Field Lab‐on‐Chip Integrated in Super‐Resolution Microscope for Cytoskeleton Imaging

2019 ◽  
Vol 5 (3) ◽  
pp. 1900669 ◽  
Author(s):  
Daniel Havelka ◽  
Djamel Eddine Chafai ◽  
Ondrej Krivosudský ◽  
Anastasiya Klebanovych ◽  
František Vostárek ◽  
...  
Keyword(s):  
Electric Field ◽  
Super Resolution ◽  
Pulsed Electric Field ◽  
Lab On Chip ◽  
Nanosecond Pulsed Electric Field ◽  
On Chip

scholarly journals Autofocusing Algorithm for Pixel-Super-Resolved Lensfree On-Chip Microscopy

2021 ◽  
Vol 9 ◽  
Author(s):  
Yumin Wu ◽  
Linpeng Lu ◽  
Jialin Zhang ◽  
Zhuoshi Li ◽  
Chao Zuo
Keyword(s):  
Focal Plane ◽  
Super Resolution ◽  
Propagation Distance ◽  
Low Noise ◽  
Wide Field ◽  
Low Resolution ◽  
Image Sharpness ◽  
Critical Function ◽  
Microscopy Technique ◽  
On Chip

In recent years, lensfree on-chip microscopy has developed into a promising and powerful computational optical microscopy technique that allows for wide-field, high-throughput microscopic imaging without using any lenses. However, due to the limited pixel size of the state-of-the-art image sensors, lens-free on-chip microscopy generally suffers from low imaging resolution, which is far from enough to meet the current demand for high-resolution microscopy. Many pixel super-resolution techniques have been developed to solve or at least partially solve this problem by acquiring a series of low-resolution holograms with multiple lateral sub-pixel shifting or axial distances. However, the prerequisite of these pixel super-resolution techniques is that the propagation distance of each low-resolution hologram can be obtained precisely, which faces two major challenges. On the one hand, the captured hologram is inherent pixelated and of low resolution, making it difficult to determine the focal plane by evaluating the image sharpness accurately. On the other hand, the twin-image is superimposed on the backpropagated raw hologram, further exacerbating the difficulties in accurate focal plane determination. In this study, we proposed a high-precision autofocusing algorithm for multi-height pixel-super-resolved lensfree on-chip microscopy. Our approach consists of two major steps: individual preliminary estimation and global precise estimation. First, an improved critical function that combines differential critical function and frequency domain critical function is proposed to obtain the preliminary focus distances of different holograms. Then, the precise focus distances can be determined by further evaluating the global offset of the averaged, low-noise reconstruction from all backpropagated holograms with preliminary focus distances. Simulations and experimental results verified the validity and effectiveness of the proposed algorithm.

Multi-angle illumination with pixel super-resolution enables lensfree on-chip tomography

SPIE Newsroom ◽  
2011 ◽  
Author(s):  
Serhan Isikman ◽  
Waheb Bishara ◽  
Uzair Sikora ◽  
Oguzhan Yaglidere ◽  
Aydogan Ozcan
Keyword(s):  
Super Resolution ◽  
On Chip

scholarly journals Single-photon avalanche diode imagers in biophotonics: review and outlook

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Claudio Bruschini ◽  
Harald Homulle ◽  
Ivan Michel Antolovic ◽  
Samuel Burri ◽  
Edoardo Charbon
Keyword(s):  
Single Photon ◽  
Photon Counting ◽  
Super Resolution ◽  
Cmos Technology ◽  
Time Resolved ◽  
Avalanche Diode ◽  
The Past ◽  
Fast Pace ◽  
On Chip ◽  
Super Resolution Microscopy

Abstract Single-photon avalanche diode (SPAD) arrays are solid-state detectors that offer imaging capabilities at the level of individual photons, with unparalleled photon counting and time-resolved performance. This fascinating technology has progressed at a very fast pace in the past 15 years, since its inception in standard CMOS technology in 2003. A host of architectures have been investigated, ranging from simpler implementations, based solely on off-chip data processing, to progressively “smarter” sensors including on-chip, or even pixel level, time-stamping and processing capabilities. As the technology has matured, a range of biophotonics applications have been explored, including (endoscopic) FLIM, (multibeam multiphoton) FLIM-FRET, SPIM-FCS, super-resolution microscopy, time-resolved Raman spectroscopy, NIROT and PET. We will review some representative sensors and their corresponding applications, including the most relevant challenges faced by chip designers and end-users. Finally, we will provide an outlook on the future of this fascinating technology.

scholarly journals Super-Resolution Microscopy: On-Chip Super-Resolution Imaging with Fluorescent Polymer Films (Adv. Funct. Mater. 27/2019)

2019 ◽  
Vol 29 (27) ◽  
pp. 1970188
Author(s):  
Chenlei Pang ◽  
Jingxi Li ◽  
Mingwei Tang ◽  
Jianpu Wang ◽  
Ioanna Mela ◽  
...  
Keyword(s):  
Polymer Films ◽  
Super Resolution ◽  
Resolution Imaging ◽  
Fluorescent Polymer ◽  
On Chip ◽  
Super Resolution Microscopy

scholarly journals Directly addressable GaN-based nano-LED arrays: fabrication and electro-optical characterization

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Daria D. Bezshlyakh ◽  
Hendrik Spende ◽  
Thomas Weimann ◽  
Peter Hinze ◽  
Steffen Bornemann ◽  
...  
Keyword(s):  
Light Emitting Diode ◽  
Rapid Development ◽  
Super Resolution ◽  
Optical Characterization ◽  
Light Sources ◽  
Light Emitting ◽  
Line Array ◽  
Core Elements ◽  
On Chip ◽  
Led Arrays

Abstract The rapid development of display technologies has raised interest in arrays of self-emitting, individually controlled light sources atthe microscale. Gallium nitride (GaN) micro-light-emitting diode (LED) technology meets this demand. However, the current technology is not suitable for the fabrication of arrays of submicron light sources that can be controlled individually. Our approach is based on nanoLED arrays that can directly address each array element and a self-pitch with dimensions below the wavelength of light. The design and fabrication processes are explained in detail and possess two geometries: a 6 × 6 array with 400 nm LEDs and a 2 × 32 line array with 200 nm LEDs. These nanoLEDs are developed as core elements of a novel on-chip super-resolution microscope. GaN technology, based on its physical properties, is an ideal platform for such nanoLEDs.

scholarly journals Lensfree on-chip microscopy over a wide field-of-view using pixel super-resolution

2010 ◽  
Vol 18 (11) ◽  
pp. 11181 ◽  
Author(s):  
Waheb Bishara ◽  
Ting-Wei Su ◽  
Ahmet F. Coskun ◽  
Aydogan Ozcan
Keyword(s):  
Super Resolution ◽  
Field Of View ◽  
Wide Field ◽  
Wide Field Of View ◽  
On Chip
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