scholarly journals Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

10.3791/3872 ◽  
2012 ◽  
Author(s):  
Nutan Prasain ◽  
J. Luke Meador ◽  
Mervin C. Yoder
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Functional Characterization ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Endothelial Colony Forming Cells

Flow cytometric and functional characterization of AC133+ cells from human umbilical cord blood

2000 ◽  
Vol 108 (4) ◽  
pp. 793-800 ◽  
Author(s):  
Mirella Pasino ◽  
Tiziana Lanza ◽  
Fernando Marotta ◽  
Lucia Scarso ◽  
Pierangela De Biasio ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Functional Characterization ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Flow Cytometric

Therapeutic Potential of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

2019 ◽  
Vol 14 (6) ◽  
pp. 460-465 ◽  
Author(s):  
Jing Jia ◽  
Baitao Ma ◽  
Shaoshuai Wang ◽  
Ling Feng
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Tissue Regeneration ◽  
Umbilical Cord Blood ◽  
Therapeutic Potential ◽  
Human Umbilical Cord Blood ◽  
Proliferative Potential ◽  
Human Umbilical Cord ◽  
Preclinical Studies ◽  
Endothelial Colony Forming Cells

Endothelial progenitor cells (EPCs) are implicated in multiple biologic processes such as vascular homeostasis, neovascularization and tissue regeneration, and tumor angiogenesis. A subtype of EPCs is referred to as endothelial colony-forming cells (ECFCs), which display robust clonal proliferative potential and can form durable and functional blood vessels in animal models. In this review, we provide a brief overview of EPCs’ characteristics, classification and origins, a summary of the progress in preclinical studies with regard to the therapeutic potential of human umbilical cord blood derived ECFCs (CB-ECFCs) for ischemia repair, tissue engineering and tumor, and highlight the necessity to select high proliferative CB-ECFCs and to optimize their recovery and expansion conditions.

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