scholarly journals Paired Nanoinjection and Electrophysiology Assay to Screen for Bioactivity of Compounds using the Drosophila melanogaster Giant Fiber System

10.3791/3597 ◽  
2012 ◽  
Author(s):  
Monica Mejia ◽  
Mari D. Heghinian ◽  
Alexandra Busch ◽  
Frank Marí ◽  
Tanja A. Godenschwege
Keyword(s):  
Drosophila Melanogaster ◽  
Giant Fiber ◽  
Fiber System ◽  
Giant Fiber System

scholarly journals A computational model of the escape response latency in the Giant Fiber System of Drosophila melanogaster

2018 ◽  
Author(s):  
Hrvoje Augustin ◽  
Asaph Zylbertal ◽  
Linda Partridge
Keyword(s):  
Drosophila Melanogaster ◽  
Computational Model ◽  
Response Latency ◽  
Escape Response ◽  
Membrane Conductance ◽  
Signal Propagation ◽  
Neuronal Membrane ◽  
Giant Fiber ◽  
Fiber System ◽  
Giant Fiber System

ABSTRACTThe Giant Fiber System (GFS) is a multi-component neuronal pathway mediating rapid escape response in the adult fruit-fly Drosophila melanogaster, usually in the face of a threatening visual stimulus. Two branches of the circuit promote the response by stimulating an escape jump followed by flight initiation. Our recent work demonstrated an age-associated decline in the speed of signal propagation through the circuit, measured as the stimulus-to-muscle depolarization response latency. The decline is likely due to the diminishing number of interneuronal gap junctions in the GFS of ageing flies. In this work, we presented a realistic conductance-based, computational model of the GFS that recapitulates our experimental results and identifies some of the critical anatomical and physiological components governing the circuit’s response latency. According to our model, anatomical properties of the GFS neurons have a stronger impact on the transmission than neuronal membrane conductance densities. The model provides testable predictions for the effect of experimental interventions on the circuit’s performance in young and ageing flies.

scholarly journals Axon Termination, Pruning, and Synaptogenesis in the Giant Fiber System of Drosophila melanogaster Is Promoted by Highwire

Genetics ◽  
2017 ◽  
Vol 205 (3) ◽  
pp. 1229-1245 ◽  
Author(s):  
Melissa Borgen ◽  
Kimberly Rowland ◽  
Jana Boerner ◽  
Brandon Lloyd ◽  
Aruna Khan ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Giant Fiber ◽  
Fiber System ◽  
Axon Termination ◽  
Giant Fiber System

scholarly journals Ectopic Expression in the Giant Fiber System ofDrosophila Reveals Distinct Roles for Roundabout (Robo), Robo2, and Robo3 in Dendritic Guidance and Synaptic Connectivity

2002 ◽  
Vol 22 (8) ◽  
pp. 3117-3129 ◽  
Author(s):  
Tanja A. Godenschwege ◽  
Julie H. Simpson ◽  
Xiaoliang Shan ◽  
Greg J. Bashaw ◽  
Corey S. Goodman ◽  
...  
Keyword(s):  
Ectopic Expression ◽  
Synaptic Connectivity ◽  
Giant Fiber ◽  
Fiber System ◽  
Giant Fiber System

scholarly journals Passover: A gene required for synaptic connectivity in the giant fiber system of Drosophila

Cell ◽  
1993 ◽  
Vol 73 (5) ◽  
pp. 967-977 ◽  
Author(s):  
Santosh N. Krishnan ◽  
Erich Frei ◽  
Gary P. Swain ◽  
Robert J. Wyman
Keyword(s):  
Synaptic Connectivity ◽  
Giant Fiber ◽  
Fiber System ◽  
Giant Fiber System
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