scholarly journals Use of a Hanging-weight System for Isolated Renal Artery Occlusion

10.3791/2549 ◽  
2011 ◽  
Author(s):  
Almut Grenz ◽  
Julee H. Hong ◽  
Alexander Badulak ◽  
Douglas Ridyard ◽  
Timothy Luebbert ◽  
...  
Keyword(s):  
Renal Artery ◽  
Artery Occlusion ◽  
Weight System ◽  
Renal Artery Occlusion

Use of a hanging-weight system for isolated renal artery occlusion during ischemic preconditioning in mice

2007 ◽  
Vol 292 (1) ◽  
pp. F475-F485 ◽  
Author(s):  
Almut Grenz ◽  
Tobias Eckle ◽  
Hua Zhang ◽  
Dan Yang Huang ◽  
Manfred Wehrmann ◽  
...  
Keyword(s):  
Renal Artery ◽  
Ischemic Preconditioning ◽  
Renal Injury ◽  
Molecular Mechanisms ◽  
Artery Occlusion ◽  
Weight System ◽  
Urinary Flow ◽  
Vascular Pedicle ◽  
Transcriptional Responses ◽  
Renal Artery Occlusion

Renal failure from ischemia contributes to morbidity and mortality. Ischemic preconditioning (IP) represents a powerful strategy for kidney protection, and recent advances in transgenic mice may help elucidate its molecular mechanisms. However, murine IP is technically challenging and experimental details significantly influence results. Thus we developed a novel model for renal IP using a hanging-weight system for isolated renal artery occlusion. In contrast to previous models, this technique eliminates the need for clamping the vascular pedicle (artery/vein). In fact, assessment of renal injury after different time periods of ischemia (10–60 min) revealed highly reproducible increases in plasma creatinine and potassium levels, while creatinine clearance, urinary flow and potassium/sodium excretion were significantly attenuated. Using different numbers of IP cycles, we found maximal protection with four cycles of 4 min of ischemia-reperfusion. In contrast, no significant renal protection was observed with IP of the vascular pedicle. To assess transcriptional responses in this model, we isolated RNA from preconditioned kidneys and found time-dependent induction of erythropoietin mRNA and plasma levels with IP. Taken together, this model provides highly reproducible renal injury and protection by IP, thus minimizing variability associated with previous techniques based on clamping of the renal pedicle. Further studies on renal ischemia/IP in mice may consider this technique.

scholarly journals Osteogenesis imperfecta with right renal artery occlusion

2012 ◽  
Vol 2012 (sep05 2) ◽  
pp. bcr2012006536-bcr2012006536 ◽  
Author(s):  
A. K. Vaish ◽  
N. Kumar ◽  
N. Jain ◽  
A. Agarwal
Keyword(s):  
Osteogenesis Imperfecta ◽  
Renal Artery ◽  
Artery Occlusion ◽  
Renal Artery Occlusion

Renal Function Salvage After Delayed Endovascular Revascularization of Acute Renal Artery Occlusion in Patients With Fenestrated-Branched Endovascular Aneurysm Repair or Visceral Debranching

2018 ◽  
Vol 25 (4) ◽  
pp. 466-473 ◽  
Author(s):  
Franziska Heidemann ◽  
Tilo Kölbel ◽  
E. Sebastian Debus ◽  
Holger Diener ◽  
Sebastian W. Carpenter ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Artery ◽  
Stent Graft ◽  
Aortic Surgery ◽  
Artery Occlusion ◽  
Aspiration Thrombectomy ◽  
Endovascular Revascularization ◽  
Renal Artery Occlusion ◽  
Local Lysis

Purpose: To analyze the renal function and outcome after delayed (>6 hours) endovascular revascularization of acute renal artery occlusion (RAO) in patients with fenestrated-branched endovascular aneurysm repairs (EVARs) or open visceral debranching. Methods: A single-center retrospective analysis was conducted involving 7 patients (mean age 61 years, range 49–72; 5 women) with 9 RAOs treated with endovascular revascularization between December 2014 and March 2017. Three patients had a solitary kidney with chronic renal insufficiency; 1 patient had bilateral occlusions as the acute event. Initial aortic surgery included 5 branched and 1 fenestrated EVAR as well as 1 open visceral debranching operation. Revascularization of the RAO was performed using aspiration thrombectomy, local lysis therapy, and stent-graft relining. The median time between initial aortic surgery and RAO was 10 months (range 0.5–17). Results: Median renal ischemic time to revascularization was 24 hours (range 7–168). Technical success was 100%, with 1 procedure-related access complication. Temporary dialysis dependency occurred in 4 patients. Mean in-hospital stay was 17 days (range 7–32) with 1 postoperative death at day 10 due to cardiac arrest of unknown cause. Mean follow-up was 10.3 months (range 1.5–27) in 5 of 6 discharged patients. During follow-up, 1 reintervention for recurrent occlusion was performed. At follow-up imaging, all renal arteries were patent. No permanent dialysis dependency occurred. Conclusion: Renal function can be salvaged by delayed revascularization for RAO with prolonged renal ischemia. The endovascular approach with aspiration thrombectomy, local lysis, and stent-graft relining is a feasible technique for revascularization after RAO in patients with fenestrated-branched EVAR or open visceral debranching.

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

10.3791/62230 ◽  
2021 ◽  
Author(s):  
Ilias P. Doulamis ◽  
Alvise Guariento ◽  
Mossab Y. Saeed ◽  
Rio S. Nomoto ◽  
Thomas Duignan ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Animal Model ◽  
Renal Artery ◽  
Kidney Injury ◽  
Artery Occlusion ◽  
Large Animal Model ◽  
Large Animal ◽  
Renal Artery Occlusion ◽  
Bilateral Renal Artery

Characterization of the postocclusive response of renal blood flow in the cat

1978 ◽  
Vol 235 (4) ◽  
pp. F286-F290 ◽  
Author(s):  
W. S. Spielman ◽  
H. Osswald
Keyword(s):  
Blood Flow ◽  
Angiotensin Ii ◽  
Renal Artery ◽  
Renal Blood Flow ◽  
Artery Occlusion ◽  
Renal Nerves ◽  
Vasoconstrictor Response ◽  
Renal Artery Occlusion ◽  
Chronic Denervation

In contrast to the postocclusive hyperemia of brain, heart, and skeletal muscle, the hemodynamic response of the kidney following renal artery occlusion is highly variable in that both hyperemia and ischemia have been reported. The present study evaluates the factors influencing the renal response to complete renal artery occlusion (5-60 s) in the anesthetized cat. Marked postocclusive vasoconstriction could only be domonstrated in meclofenamate-treated (10 mg/kg) cats. The delta% renal blood flow (RBF) (30-s occlusion) was 16 +/- 4 in controls and 54 +/- 4 after meclofenamate (n= 10; P less than 0.001). Chronic denervation of the kidney, alpha-adrenergic receptor blockade, or infusion of [Sar1, Ile8]angiotensin II(2 microgram/min per kg) did not affect the postocclusive reduction of RBF, indicating that the vasoconstriction was independent of renal nerves, catecholamines, and circulating angiotesin II. Adenosine injected into the renal artery of five cats caused a dose-dependent transient fall of RBF. A dose of 100 nmol adenosine reduced RBF by 44 +/- 6% whereas after meclofenamate only 1 nmol produced the same degree of vasoconstriction. In summary, this study demonstrates a marked potentiation of the postocclusive vasoconstrictor response and the vasoconstrictive action of adenosine by meclofenamate in the anesthetized animal. No evidence was obtained to support a role for the sympathetic nervous system or circulating angiotensin II in mediating the postocclusive vasoconstriction.

scholarly journals Transient hypertension caused by segmental renal artery occlusion.

BMJ ◽  
1969 ◽  
Vol 4 (5680) ◽  
pp. 408-410 ◽  
Author(s):  
H B Benraad ◽  
T J Benraad ◽  
P W Kloppenborg
Keyword(s):  
Renal Artery ◽  
Artery Occlusion ◽  
Renal Artery Occlusion ◽  
Segmental Renal Artery

Acute Renal Artery Occlusion and Trapped Renal Artery Catheter During Infrarenal AAA Stent Grafting

2013 ◽  
pp. 139-147
Author(s):  
Robert P. Allison ◽  
Anna Maria Belli ◽  
Joo-Young Chun ◽  
Raymond Chung ◽  
Raj Das ◽  
...  
Keyword(s):  
Renal Artery ◽  
Artery Occlusion ◽  
Stent Grafting ◽  
Renal Artery Occlusion
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