scholarly journals Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord

10.3791/1324 ◽  
2009 ◽  
Author(s):  
John D. Houle ◽  
Arthi Amin ◽  
Marie-Pascale Cote ◽  
Michel Lemay ◽  
Kassi Miller ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Peripheral Nerve ◽  
Nerve Grafting ◽  
Rat Spinal Cord ◽  
Peripheral Nerve Grafting

scholarly journals Reduction in post-spinal cord injury spasticity by combination of peripheral nerve grafting and acidic fibroblast growth factor infusion in monkeys

2021 ◽  
Vol 49 (6) ◽  
pp. 030006052110222
Author(s):  
Wei-Ming Sun ◽  
Chao-Lin Ma ◽  
Jiang Xu ◽  
Ji-Ping He
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Growth Factor ◽  
Peripheral Nerve ◽  
Fibroblast Growth Factor ◽  
Nerve Grafting ◽  
Fibroblast Growth ◽  
Acidic Fibroblast Growth Factor ◽  
Cord Injury ◽  
Peripheral Nerve Grafting

Objective Spasticity is a frequent complication after spinal cord injury (SCI), but the existing therapies provide only limited relief and are associated with adverse reactions. Therefore, we aimed to develop a novel strategy to ameliorate the spasticity induced by SCI. Methods This nonrandomized controlled study used a repeated measurement design. The study involved four monkeys, two of which served as controls and only underwent spinal cord hemisection surgery at the T8 spine level. The other two monkeys underwent transplantation of sural nerve segments into the injured sites and long-term infusion of acidic fibroblast growth factor (aFGF). All monkeys received postoperative exercise training and therapy. Results The combined therapy substantially reduced the spasticity in leg muscle tone, patella tendon reflex, and fanning of toes. Although all monkeys showed spontaneous recovery of function over time, the recovery in the controls reached a plateau and started to decline after 11 weeks. Conclusions The combination of peripheral nerve grafting and aFGF infusion may serve as a complementary approach to reduce the signs of spasticity in patients with SCI.

Expresion of thymosin (TB-4) in central glia of rat spinal cord following peripheral nerve injury

1994 ◽  
Vol 19 ◽  
pp. S146
Author(s):  
Koujiro Tohyama ◽  
Tetsuro Morita ◽  
Noboru Sato ◽  
Hiroyuki Yaginuma ◽  
Yasuo Uchiyama
Keyword(s):  
Spinal Cord ◽  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Rat Spinal Cord

Effects of peripheral nerve injury on delta opioid receptor (DOR) immunoreactivity in the rat spinal cord

2004 ◽  
Vol 361 (1-3) ◽  
pp. 208-211 ◽  
Author(s):  
Laura S. Stone ◽  
Lucy Vulchanova ◽  
Maureen S. Riedl ◽  
Frank G. Williams ◽  
George L. Wilcox ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Peripheral Nerve ◽  
Nerve Injury ◽  
Opioid Receptor ◽  
Peripheral Nerve Injury ◽  
Delta Opioid Receptor ◽  
Rat Spinal Cord

Effects of peripheral nerve injury on alpha-2A and alpha-2C adrenergic receptor immunoreactivity in the rat spinal cord

Neuroscience ◽  
1999 ◽  
Vol 93 (4) ◽  
pp. 1399-1407 ◽  
Author(s):  
L.S. Stone ◽  
L. Vulchanova ◽  
M.S. Riedl ◽  
J. Wang ◽  
F.G. Williams ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Adrenergic Receptor ◽  
Rat Spinal Cord
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