scholarly journals Primary Culture of Adult Rat Heart Myocytes

10.3791/1308 ◽  
2009 ◽  
Author(s):  
Xianghua Xu ◽  
Henry M. Colecraft
Keyword(s):  
Primary Culture ◽  
Rat Heart ◽  
Adult Rat ◽  
Rat Heart Myocytes

Intracellular free Ca2+ and the hypercontracture of adult rat heart myocytes

1986 ◽  
Vol 245 (2) ◽  
pp. 426-435 ◽  
Author(s):  
Mindy R. Lambert ◽  
J.David Johnson ◽  
Karla G. Lamka ◽  
Gerald P. Brierley ◽  
Ruth A. Altschuld
Keyword(s):  
Rat Heart ◽  
Adult Rat ◽  
Rat Heart Myocytes

scholarly journals Release of enzymes from adult rat heart myocytes.

1982 ◽  
Vol 51 (5) ◽  
pp. 560-568 ◽  
Author(s):  
M P Murphy ◽  
C Hohl ◽  
G P Brierley ◽  
R A Altschuld
Keyword(s):  
Rat Heart ◽  
Adult Rat ◽  
Rat Heart Myocytes

scholarly journals Effect of Anticancer Quinones on Reactive Oxygen Production by Adult Rat Heart Myocytes

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
James H. Doroshow
Keyword(s):  
Hydrogen Peroxide ◽  
Oxygen Consumption ◽  
Mitomycin C ◽  
Rat Heart ◽  
Hydrogen Peroxide Production ◽  
Anthracycline Antibiotics ◽  
Adult Rat ◽  
Radical Cascade ◽  
Rat Heart Myocytes ◽  
Oxygen Radical Production

This study investigated the effect of anthracycline antibiotics, mitomycin C, and menadione on oxygen consumption and hydrogen peroxide production by intact, beating, rat heart myocytes. Doxorubicin produced a dose-dependent increase in the rate of cyanide-resistant respiration by beating myocytes. The anthracycline analogs 4-demethoxydaunorubicin, 4 ′ -epidoxorubicin, 4 ′ -deoxydoxorubicin, and menogaril, as well as the anticancer quinones mitomycin C and menadione, also significantly increased oxygen consumption by cardiac myocytes. However, 5-iminodaunorubicin (which has a substituted quinone group) and mitoxantrone (which is not easily reduced by flavin dehydrogenases) had no effect on cardiac respiration. Both catalase (43%) and acetylated cytochrome c (19%) significantly decreased oxygen consumption that had been stimulated by doxorubicin; furthermore, extracellular hydrogen peroxide production was increased from undetectable control levels to 1.30 ± 0.02  nmol/min/107 myocytes ( n = 4 , P < 0.01 ) in the presence of 400 μM doxorubicin. These experiments suggest that the anthracycline antibiotics and other anticancer quinones stimulate cardiac oxygen radical production in intact heart myocytes; such a free radical cascade could contribute to the cardiac toxicity of these drugs.

scholarly journals Carnitine transport in isolated adult rat heart myocytes and the effect of 7,8-diOH chlorpromazine.

1981 ◽  
Vol 48 (3) ◽  
pp. 378-385 ◽  
Author(s):  
J Bahl ◽  
T Navin ◽  
A A Manian ◽  
R Bressler
Keyword(s):  
Rat Heart ◽  
Adult Rat ◽  
Carnitine Transport ◽  
Rat Heart Myocytes

scholarly journals Degradation and resynthesis of adenine nucleotides in adult rat heart myocytes.

1987 ◽  
Vol 262 (28) ◽  
pp. 13527-13533
Author(s):  
R A Altschuld ◽  
L M Gamelin ◽  
R E Kelley ◽  
M R Lambert ◽  
L E Apel ◽  
...  
Keyword(s):  
Rat Heart ◽  
Adenine Nucleotides ◽  
Adult Rat ◽  
Rat Heart Myocytes
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