scholarly journals Difficulties of diagnosis and treatment in a case of malignant melanoma

2015 ◽  
Vol 62 (3) ◽  
pp. 307-312
Author(s):  
Marieta Petrescu ◽  
◽  
Adrian Alexandru ◽  
Andreea Benga ◽  
Doina Dumitrescu ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Malignant Melanoma ◽  
Mortality Rate ◽  
Stage Iv ◽  
Primary Diagnosis ◽  
Rare Form ◽  
Biological Condition ◽  
Skin Cancers ◽  
Melanoma Patients ◽  
Therapeutic Possibilities

Malignant melanoma is a rare form of skin cancer, which is only about 3-4% of all skin cancers, but results in a mortality rate up to 65-70%. The vast majority of melanomas are diagnosed in stage 0, I and II, but there were cases when the primary diagnosis of malignant melanoma patients was put directly in stage IV metastatic disseminated lymph nodes, lung, liver, spleen, bone, brain. In the case of a patient with metastatic melanoma, poor biological condition limits the diagnostic and therapeutic possibilities.

Surgical Management of Melanoma and Other Skin Cancers

2015 ◽  
Author(s):  
Jennifer A. Wargo ◽  
Kenneth Tenabe
Keyword(s):  
Lymph Node ◽  
Surgical Treatment ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Stage Iv ◽  
Stage Iii ◽  
Non Melanoma Skin Cancer ◽  
Skin Cancers ◽  
Stage Iv Melanoma ◽  
Melanoma Skin

The prevalence of malignant skin cancers has increased significantly over the past several years. Approximately 1.2 million cases of non-melanoma skin cancer are diagnosed per year. More alarming, up to 80,000 cases of melanoma are diagnosed per year, an incidence that has been steadily increasing, with a lifetime risk of 1 in 50 for the development of melanoma. The disturbing increase in the incidence of both non-melanoma skin cancer and melanoma can largely be attributed to the social attitude toward sun exposure. The clinical assessment and management of skin lesions can be challenging. This review describes the assessment process, including thorough history and examination; the need for possible biopsy; and excision criteria. Specific types of skin cancer are distinguished and include basal cell carcinoma; squamous cell carcinoma; and melanoma; and for each type the incidence; epidemiology; histologic subtypes; diagnosis; and both surgical and non-surgical treatments are provided. Stages I-IV of melanoma are detailed, with prognostic factors described. Surgical treatment for stages I and II include description of the margins of excision and sentinel lymph node biopsy. The surgical treatment of Stage III melanoma further includes therapeutic lymph node dissection and isolated limb perfusion. Adjuvant therapies are also presented and include radiotherapy and chemotherapy. The additional treatment of metastasectomy for Stage IV melanoma is described. For both Stage III and IV melanoma, the study of vaccines to host immune cells is reported. For Stage IV melanoma, the text also describes immunotherapy treatment. Operative procedures specific to superficial and deep groin dissections are outlined. This review contains 9 figures, 3 tables, and 96 references.

Management of Malignant Melanoma: Best Practices

2009 ◽  
Vol 13 (2) ◽  
pp. 55-73 ◽  
Author(s):  
Michael Smylie ◽  
Joël Claveau ◽  
Kenneth Alanen ◽  
Raymond Taillefer ◽  
Ralph George ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Best Practices ◽  
Gamma Probe ◽  
Treatment Options ◽  
Stage Iv ◽  
Primary Diagnosis ◽  
Interferon Α ◽  
Node Biopsy ◽  
Stage Iv Disease ◽  
Intraoperative Gamma Probe

Background: Melanoma is a commonly occurring cancer in Canada, with an estimated age-standardized incidence of 10 to 13 per 100,000. An estimated 4,300 new cases were diagnosed, and there were 880 reported deaths in 2005. Objective and Conclusion: The Canadian Expert Panel on Malignant Melanoma has developed best practices to improve the management of malignant melanoma. Sections include recommendations on primary diagnosis, dermatopathologic assessment, and reporting; use of preoperative lymphoscintigraphy and an intraoperative gamma probe to map and biopsy the sentinel lymph node; indications for surgical resection, sentinel node biopsy, and surgery for advanced disease; use of interferon-α adjuvant therapy and treatment options for stage IV disease; and management of central nervous system metastases.

scholarly journals A rare case of intracranial malignant melanoma with an unusual presentation

2016 ◽  
Vol 7 (6) ◽  
pp. 91-93
Author(s):  
Sandeep B V ◽  
Suniti Kumar Saha ◽  
Manpreet Singh Banga ◽  
Partha Ghosh
Keyword(s):  
Skin Cancer ◽  
Malignant Melanoma ◽  
Head And Neck ◽  
Rare Case ◽  
Medical Sciences ◽  
Skin Cancers ◽  
Common Skin ◽  
The Common ◽  
Sixth Decade ◽  
Geographical Locations

Among the common skin cancers, melanoma is the most lethal. Although, it comprises only 3% of all skin cancers diagnosed , it accounts for about  75% of all skin cancer-related deaths. Melanoma is a relatively uncommon skin cancer in geographical locations like India. Its highest incidence is seen in sixth decade . Head and neck melanomas constitute approximately 17% of all cutaneous melanomas .We present a 15 year old male patient who presented with a intracranial melanoma with osteolytic skull lesion.Asian Journal of Medical Sciences Vol.7(5) 2016 91-93

Bleomycin, vinorelbine and trofosfamide in relapsed stage IV cutaneous malignant melanoma patients

2009 ◽  
Vol 64 (5) ◽  
pp. 901-905 ◽  
Author(s):  
Jens Atzpodien ◽  
Lars Morawek ◽  
Michael Fluck ◽  
Martina Reitz
Keyword(s):  
Malignant Melanoma ◽  
Stage Iv ◽  
Cutaneous Malignant Melanoma ◽  
Melanoma Patients

scholarly journals Risks of Squamous Cell Carcinoma of The Lip and Cutaneous Melanoma in Older Australians Using Hydrochlorothiazide (HTCZ)

2020 ◽  
Vol 5 (5) ◽  
Author(s):  
Benjamin Daniels ◽  
Sallie-Anne Pearson ◽  
Claire M Vajdic ◽  
Anton Pottegård ◽  
Nicholas A Buckley ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Malignant Melanoma ◽  
Cutaneous Melanoma ◽  
Conditional Logistic Regression ◽  
Skin Cancer Prevention ◽  
Department Of Veterans Affairs ◽  
Lip Cancer ◽  
Skin Cancers ◽  
Incident Cases ◽  
Control Study

IntroductionHCTZ is first-line treatment for hypertension and among the most commonly used medicines in Australia. Recent evidence suggests increased risks of lip and skin cancers in association with HCTZ use. Objectives and ApproachTo determine the risk of SCC of the lip and melanoma among people prescribed HCTZ in Australia we conducted a case-control study nested within a cohort of Department of Veterans’ Affairs clients 65 years and older in 2004-2015. We identified incident cases of SCC of the lip (lip cancer) and of cutaneous melanoma (malignant melanoma), each matched by sex and age with up to 20 controls through risk-set sampling. We ascertained HCTZ use from dispensing data and classified use according to ever/never use and cumulative use. We estimated odds ratios (ORs) associating HCTZ use with lip cancer and malignant melanoma using conditional logistic regression, adjusting for predefined confounders obtained from dispensing and hospitalisation data. ResultsFor lip cancer (45 cases) ever-use of HCTZ yielded an OR of 2.6 (95%CI: 1.4–5.0) and high HCTZ use (>25,000mg) an OR of 4.7 (1.61–13.7). For malignant melanoma (659 cases) ever-use of HCTZ resulted in an OR of 1.2 (1.0–1.5) and high HCTZ use in an OR of 1.2 (0.8–1.8). Conclusion / ImplicationsOur study provides further evidence that the photosensitising properties of HCTZ may promote SCC carcinogenesis, and possibly melanoma, in susceptible sun-exposed tissues. Our findings are the first from the Australian population—already at elevated risk of developing skin cancer—and add to the growing body of data supporting the need for skin cancer prevention advice and behaviours, and potentially heightened surveillance, for individuals prescribed this medication.

scholarly journals Comparative Analysis of Skin Cancer (Benign vs. Malignant) Detection Using Convolutional Neural Networks

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Mohammed Rakeibul Hasan ◽  
Mohammed Ishraaf Fatemi ◽  
Mohammad Monirujjaman Khan ◽  
Manjit Kaur ◽  
Atef Zaguia
Keyword(s):  
Skin Cancer ◽  
Mortality Rate ◽  
Support Vector ◽  
Work Processes ◽  
Abnormal Growth ◽  
Skin Cells ◽  
Skin Cancers ◽  
Malignant Skin ◽  
Common Skin ◽  
Cancer Spread

We live in a world where people are suffering from many diseases. Cancer is the most threatening of them all. Among all the variants of cancer, skin cancer is spreading rapidly. It happens because of the abnormal growth of skin cells. The increase in ultraviolet radiation on the Earth’s surface is also helping skin cancer spread in every corner of the world. Benign and malignant types are the most common skin cancers people suffer from. People go through expensive and time-consuming treatments to cure skin cancer but yet fail to lower the mortality rate. To reduce the mortality rate, early detection of skin cancer in its incipient phase is helpful. In today’s world, deep learning is being used to detect diseases. The convolutional neural network (CNN) helps to find skin cancer through image classification more accurately. This research contains information about many CNN models and a comparison of their working processes for finding the best results. Pretrained models like VGG16, Support Vector Machine (SVM), ResNet50, and self-built models (sequential) are used to analyze the process of CNN models. These models work differently as there are variations in their layer numbers. Depending on their layers and work processes, some models work better than others. An image dataset of benign and malignant data has been taken from Kaggle. In this dataset, there are 6594 images of benign and malignant skin cancer. Using different approaches, we have gained accurate results for VGG16 (93.18%), SVM (83.48%), ResNet50 (84.39%), Sequential_Model_1 (74.24%), Sequential_Model_2 (77.00%), and Sequential_Model_3 (84.09%). This research compares these outcomes based on the model’s work process. Our comparison includes model layer numbers, working process, and precision. The VGG16 model has given us the highest accuracy of 93.18%.

scholarly journals Nail Mélanoma

2021 ◽  
Vol 6 (1) ◽  
pp. 01-02
Author(s):  
H. Palamino ◽  
F. Elgaitibi ◽  
M. Meziane ◽  
N. Ismaili ◽  
L. Benzekri ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Malignant Melanoma ◽  
Malignant Tumor ◽  
Metastatic Potential ◽  
Rare Form ◽  
High Metastatic Potential

Melanoma is originating from melanocytes, it is a malignant tumor with high metastatic potential. It is the leading cause of moratlity from skin cancer, Nail melanoma is a rare form of malignant melanoma. we report a new case of this rare localization

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