scholarly journals ESSENTIAL OILS, A POSSIBLE SOLUTION TO OVERCOME ANTIMICROBIAL RESISTANCE CRISIS

2015 ◽  
Vol 62 (3) ◽  
pp. 280-283
Author(s):  
Adrian-Vasile Craciun ◽  
◽  
Daniela Chiru ◽  
Otilia Marginean ◽  
◽  
...  
Keyword(s):  
Cell Wall ◽  
Antifungal Activity ◽  
Essential Oils ◽  
Action Spectrum ◽  
Current Medical ◽  
Ideal Solution ◽  
Pathogenic Microorganisms ◽  
Current Medical Practice ◽  
Antifungal Action ◽  
Defensive Mechanisms

Having emerged as an ideal solution against pathogenic microorganisms, antimicrobial medication seems to have lost the battle today. The ability of the living world to survive and adapt exceeds the synthetic products power of action, leading us today to a real crisis of microbial resistance to antibiotics. An unexpected solution may come also from the bosom of nature, by reconsidering the role and place of the essential oils as antimicrobial combat weapons. Defensive mechanisms created by nature, the essential oils demonstrate extraordinary antibacterial, antiviral and antifungal activity. They also help the synthetic antibiotics in their battle. Among the essential oils and the antibiotics, often intervene synergistic or additive interactions. The essential oils favor the antibiotics to penetrate through the cell wall and to extend their action spectrum. Undoubtedly, essential oils can be of crucial help in the current medical practice, through their complex antibacterial, antiviral and antifungal action.

scholarly journals Antifungal activity of Ocotea odorifera (Vell.) Rowher, Ocotea puberula (Rich.) Nees and Cinnamodendron dinisii Schwanke essential oils

2019 ◽  
Author(s):  
P. Mezzomo ◽  
T.L. Sausen ◽  
N. Paroul ◽  
S.S. Roman ◽  
A.A.P. Mielniczki ◽  
...  
Keyword(s):  
Gas Chromatography ◽  
Antifungal Activity ◽  
Essential Oil ◽  
Essential Oils ◽  
Inhibitory Concentration ◽  
Chemical Compounds ◽  
Inhibitory Effect ◽  
Pathogenic Microorganisms ◽  
Biological Interest ◽  
Penicillium Crustosum

AbstractBiocompounds are promising tools with the potential to control pathogenic microorganisms. The medicinal plant species Ocotea odorifera, Ocotea puberula and Cinnamodendron dinisii, distributed along Brazilian biomes, are sources of chemical compounds of biological interest. This study aimed to evaluate the antifungal activity of the essential oils of O. odorifera, O. puberula and C. dinisii essential oils upon the mycotoxin producers Alternaria alternata, Aspergillus flavus and Penicillium crustosum. The essential oils where characterized by gas chromatography coupled to mass spectrometer (CG-MS). The majority compounds identified were: safrol (39.23%) and camphor (31.54%) in O. odorifera, Beta-caryophyllene (25.01%) and spathulenol (17.74%) in O. puberula, and bicyclogermacrene (23.19%) and spathulenol (20.21%) in C. dinisii. The Minimal Inhibitory Concentration (MIC) of antifungal activity considered diameters higher than 10 mm after 72 h of incubation at 30 ºC. A. alternata presented higher resistance to O. odorifera and C. dinisii oils. The inhibitory effect of O. odorifera on A. flavus showed stabilization at oils concentrations between 50% and 80%, increasing at 90% and 100% (pure oil) treatments. We observed that the essential oils of O. odorifera and C. dinisii have potential in the control of the analyzed fungi species. The essential oil of O. odorifera presented a better activity in all the assays, which can be related to the presence of safrole and phenylpropenes, compounds with known antifungal activity.

scholarly journals Antifungal activity of essential oils from Cinnamomum cassia, Myristica fragrans and Syzygium aromaticum against Rhodotorula mucilaginosa

2020 ◽  
Vol 4 (2) ◽  
pp. 3-11
Author(s):  
Juliana Caroline Butzge ◽  
Simone Krause Ferrão ◽  
Letícia Mezzomo ◽  
Luciane Noal Calil ◽  
Adelina Mezzari ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Essential Oils ◽  
Clinical Isolates ◽  
Syzygium Aromaticum ◽  
Main Compound ◽  
Cinnamomum Cassia ◽  
Myristica Fragrans ◽  
Agar Disc ◽  
Antifungal Action ◽  
Clinical Conditions

Rhodotorula genus comprises yeasts from Sporidiobolaceae family. Considered as non-pathogenic until the last two decades, different species of Rhodotorula are emerging as pathogens in humans, with R. mucilaginosa being the most commonly involved in infections, ranging from simpler clinical conditions such as skin manifestations to more severe cases such as meningitis and endocarditis. The major facilitating agents for the emergence of these infections are invasive procedures such as catheter implants. The primary drugs of choice used to treat these infections are amphotericin B and fluconazole. However, some strains of this yeast show different degrees of resistance to these substances, thus justifying the search for new therapeutic agents. Considering this, the present study aims the investigation of the antifungal activity of the essential oils of Cinnamomum cassia (cinnamon), Syzygium aromaticum (clove) and Myristica fragrans (nutmeg) against clinical isolates of R. mucilaginosa. The essential oils were obtained by hydrodistillation and characterized by GC-MS. The investigation of the antifungal action activity was performed by the agar disc-diffusion test followed by the Minimum Inhibitory Concentration (MIC) determination. All the essential oils were species present their oil characterized by the presence of phenylpropanoids, with eugenol (77.6 to 94.4%) as the main compound of clove and E-cinnamaldehyde (90.4 to 100%) of cinnamon. Nutmeg oil is characterized by the presence of showed as main compounds the myristicin (1.8 a 12.8%) and elemicin (4.3 a 11.1%) phenylpropanoids, besides sabinene (28.2 to 44.4%) and terpinen-4-ol (16.0 to 19.5%) monoterpenes. In the investigation of antifungal activity, all the oils showed potential action against clinical isolates of R. mucilaginosa, with MICs ranging from 8 to 500 µg/mL. The results demonstrate that these oils are promising candidates in the search for new anti-Rhodotorula agents, enabling the treatment of aforementioned infections.

Antimicrobial activity of essential oils onto pathogenic microorganisms of interest to dentistry

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
VR Santos ◽  
VA Noronha ◽  
JC Silva ◽  
FF Silva ◽  
TF Machado ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oils ◽  
Pathogenic Microorganisms

Antifungal activity analysis of 3 essential oils (thyme, ajwainand orange) on candida albicans

2017 ◽  
Vol 6 (3) ◽  
pp. 2948-2950
Author(s):  
Vaishnavi Sivakali Subramanian ◽  
◽  
R.V Geetha ◽  
Anitha Roy ◽  
◽  
...  
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Essential Oils ◽  
Activity Analysis

Antifungal Activity Directed Toward the Cell Wall by 2-Cyclohexylidenhydrazo- 4-Phenyl-Thiazole Against Candida albicans

2019 ◽  
Vol 19 (4) ◽  
pp. 428-438 ◽  
Author(s):  
Nívea P. de Sá ◽  
Ana P. Pôssa ◽  
Pilar Perez ◽  
Jaqueline M.S. Ferreira ◽  
Nayara C. Fonseca ◽  
...  
Keyword(s):  
Cell Wall ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Mammalian Cells ◽  
C Elegans ◽  
Buccal Epithelial Cells ◽  
Mutant Strains ◽  
Low Toxicity ◽  
High Concentrations ◽  
Mic Value

<p>Background: The increasing incidence of invasive forms of candidiasis and resistance to antifungal therapy leads us to seek new and more effective antifungal compounds. </P><P> Objective: To investigate the antifungal activity and toxicity as well as to evaluate the potential targets of 2- cyclohexylidenhydrazo-4-phenyl-thiazole (CPT) in Candida albicans. </P><P> Methods: The antifungal activity of CPT against the survival of C. albicans was investigated in Caenorhabditis elegans. Additionally, we determined the effect of CPT on the inhibition of C. albicans adhesion capacity to buccal epithelial cells (BECs), the toxicity of CPT in mammalian cells, and the potential targets of CPT in C. albicans. </P><P> Results: CPT exhibited a minimum inhibitory concentration (MIC) value of 0.4-1.9 µg/mL. Furthermore, CPT at high concentrations (>60 x MIC) showed no or low toxicity in HepG2 cells and <1% haemolysis in human erythrocytes. In addition, CPT decreased the adhesion capacity of yeasts to the BECs and prolonged the survival of C. elegans infected with C. albicans. Analysis of CPT-treated cells showed that their cell wall was thinner than that of untreated cells, especially the glucan layer. We found that there was a significantly lower quantity of 1,3-β-D-glucan present in CPT-treated cells than that in untreated cells. Assays performed on several mutant strains showed that the MIC value of CPT was high for its antifungal activity on yeasts with defective 1,3-β-glucan synthase. </P><P> Conclusion: In conclusion, CPT appears to target the cell wall of C. albicans, exhibits low toxicity in mammalian cells, and prolongs the survival of C. elegans infected with C. albicans.</p>

Chemical composition and antifungal activity of essential oils and their combinations against Botrytis cinerea in strawberries

2021 ◽  
Author(s):  
Josemar Gonçalves de Oliveira Filho ◽  
Guilherme da Cruz Silva ◽  
Aline Cristina de Aguiar ◽  
Lavinia Cipriano ◽  
Henriette Monteiro Cordeiro de Azeredo ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Antifungal Activity ◽  
Essential Oils ◽  
Botrytis Cinerea
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