scholarly journals Phytochemical Analysis and Anticancer Activity of Azadirachta Indica Ethanolic Extract against A549 Human Lung Cancer Cell Line

2021 ◽  
Vol 2 (4) ◽  
pp. 280-285
Author(s):  
MS Azhagu
Keyword(s):  
Azadirachta Indica ◽  
Human Lung ◽  
A549 Cells ◽  
Cancer Cell Line ◽  
Ethanolic Extract ◽  
Lung Cancer Cell Line ◽  
Human Lung Cancer ◽  
Phytochemical Analysis ◽  
Lung Cancer Cell ◽  
Malignant Growth

Azadirachta indica phytochemicals are found to have against malignant growth and hostile to bacterial properties. In the specific examination, the coupling proficiency of five mixes that are available in the Azadirachta indica with all the eleven proteins through in silico techniques was completed. Plant removes ensure against harmful compound instigated injury by expanding the body’s degrees of cell reinforcement particles, for example, glutathione, and improving the action of cancer prevention agent chemicals. A549 cells treated with Azadirachta indica ethanolic separate in various hours (6, 12, 24 and 36 hours) after the 36 hours the cells development are controlled. As there are re-established interests in home grown based meds to hinder the results of manufactured medications, Azadirachta Indica L. a leaf contains phytochemical intensifies having all the more free revolutionary rummaging just as anticancer exercises.

scholarly journals Phytochemical Analysis and Anticancer Activity of Ethanolic Extract Against A549 Human Lung Cancer Cell Line Azadirachta Indica

2021 ◽  
Vol 2 (1) ◽  
pp. 29-38
Author(s):  
S. Azhagu Madhavan
Keyword(s):  
Lung Cancer ◽  
Azadirachta Indica ◽  
Human Lung ◽  
Cancer Cell Line ◽  
Ethanolic Extract ◽  
Lung Cancer Cell Line ◽  
Human Lung Cancer ◽  
Phytochemical Analysis ◽  
Lung Cancer Cell ◽  
Malignant Growth

Azadirachta indica phytochemicals are found to be effective against malignant growth and hostile to bacterial properties. In the specific examination, the coupling proficiency of five mixes that are available in the Azadirachta indica with all the eleven proteins through in silico techniques was completed. Plant removes harmful compound instigated injury by expanding the body's degrees of cell reinforcement particles. For example, they affect the glutathione, and improving the action of cancer prevention agent chemicals. About 549 cells treated with Azadirachta indica ethanolic separated in various hours (6, 12, 24 and 36 hours). After 36 hours, the cells development was controlled. There are re-established interests in home grown based meds to hinder the results of manufactured medications, Azadirachta Indica L. A leaf contains phytochemical intensifies that has all freer revolutionary rummaging just as anticancer exercises.

scholarly journals The Effects of 2,2',4'-Trihydroxychalcone on the Cell Proliferation, Metastasis, and Apoptosis in Human Lung Cancer Cell Line A549

2021 ◽  
Author(s):  
Jialin Sun ◽  
Zhanqi Cao ◽  
Shiwei Sun ◽  
Zhonghua Sun ◽  
Shuhong Sun ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Human Lung ◽  
Vasculogenic Mimicry ◽  
A549 Cells ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Related Proteins

Abstract Objectives：Our study aimed to evaluate the antitumor effects of 2,2',4'-trihydroxychalcone (7a) on human lung cancer cell line A549. Methods：A549 cells were treated with different concentrations of 7a for different times. The cells without 7a were set as the negative control group. The cell proliferation, invasion, vasculogenic mimicry (VM) formation, heterogeneous adhesion, apoptosis were, respectively, measured by CCK-8, transwell invasion assay, vasculogenic mimicry assay, adhesion assay and flow cytometry. In addition, the expression of related proteins were examined via western blot or ELISA. Results：Our research found that 7a had a significant inhibitory effect on the survival rate of lung cancer A549 cells, while almost had no effect on human lung epithelial BEAS-2B cells and human venous endothelial cells (HUVECs). The migration rate, VM length, invasion and heterogeneous adhesion number of cells treated with 7a significantly decreased as the increase in concentration, while the apoptosis rate increased. Western blot analysis showed that 7a treatment significantly upregulated the expression of E-cadherin, cleaved PARP, Bax, caspase-3, and simultaneously downregulated the expression of MMP-2/9, Bcl-2, p-PI3K, p-Akt, p-MTOR, VEGF, E-selectin and N-cadherin. At the same time, ELISA results found that the pro-angiogenic factor VEGF level in culture media was reduced in the presence of 7a. Additionally, 7a could also reduce the nucleus NF-κB protein level, which would inhibit gene transcription of tumor activity-related proteins. Conclusion：7a might exert inhibitory effects on A549 cells via inhibiting cell proliferation, migration, VM formation, heterogeneous adhesion and inducing apoptosis through suppressing the PI3K/AKT/NF-κB signaling pathway, suggesting that 7a might have therapeutic potential for the treatment of lung cancer.

Toxic effect of TiO2 nanoparticles against human lung cancer cell line A549

2011 ◽  
Vol 31 (10) ◽  
pp. 1091-1095
Author(s):  
Xiao-lin LI ◽  
Yan-fang ZHANG ◽  
Kai TANG ◽  
Ying TANG ◽  
Ruo-bing JIN ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Toxic Effect ◽  
Cell Line ◽  
Cancer Cell ◽  
Human Lung ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell

Effect of magnetosomes on cell proliferation, apoptosis induction and expression of Bcl-2 in the human lung cancer cell line A549

Biologia ◽  
2017 ◽  
Vol 72 (5) ◽  
Author(s):  
Zuzana Varchulova Novakova ◽  
Iveta Gasparova ◽  
Lubica Krajciova ◽  
Matus Molcan ◽  
Ivan Varga ◽  
...  
Keyword(s):  
Drug Transport ◽  
Human Lung ◽  
Cancer Cell Line ◽  
Magnetotactic Bacteria ◽  
Drug Dose ◽  
Lung Cancer Cell Line ◽  
Human Lung Cancer ◽  
Apoptosis Induction ◽  
Lung Cancer Cell ◽  
Targeted Drug

AbstractMagnetosomes are nanoparticles coated with organic membrane produced by magnetotactic bacteria. They appear to be a suitable carrier for the targeted drug transport, which represents a new method of cancer treatment. Advantages of targeted drugs transport are the minimizing of hurt to the organism, specific focusing on certain types of tissues, increased effect of the drug, reduced drug dose and hence side effects. The main goal of the present study was to verify the effect of bacterial magnetic nanoparticles produced by

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