scholarly journals Cryoglobulinemia and sensorimotor polyneuropathy

2020 ◽  
Vol 40 (1) ◽  
pp. 35-37
Author(s):  
Marija Sedlić ◽  
Gordana Sičaja ◽  
Krešimir Luetić ◽  
Hrvoje Budinčević
Keyword(s):  
Hepatitis C ◽  
Peripheral Neuropathy ◽  
Early Diagnosis ◽  
Neurological Manifestations ◽  
Hepatitis C Infection ◽  
Skin Changes ◽  
Sensorimotor Polyneuropathy ◽  
Extrahepatic Manifestation

Secondary cryoglobulinemia is the most common extrahepatic manifestation of hepatitis C. There are different genotypes of hepatitis C, and the ones that are most frequently associated with cryoglobulinemia are genotypes 1b and 2a. Cryoglobulinemia affects various organs and can cause vasculitis, arthralgia, skin changes, glomerulonephritis and neurological manifestations, including peripheral neuropathy. The aim of this report was to emphasize the importance of early diagnosis of hepatitis C infection in patients who are presenting with sensomotor polyneuropathy.

Viral RNA in nerve tissues of patients with hepatitis C infection and peripheral neuropathy

2002 ◽  
Vol 27 (1) ◽  
pp. 102-104 ◽  
Author(s):  
Luisa De Martino ◽  
Simone Sampaolo ◽  
Celeste Tucci ◽  
Lucia Ambrosone ◽  
Alberta Budillon ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Peripheral Neuropathy ◽  
Viral Rna ◽  
Hepatitis C Infection

scholarly journals Anti-Glutamic Acid Decarboxylase Antibody-Associated Ataxia as an Extrahepatic Autoimmune Manifestation of Hepatitis C Infection: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-4
Author(s):  
Amer Awad ◽  
Olaf Stüve ◽  
Marlyn Mayo ◽  
Rafeed Alkawadri ◽  
Bachir Estephan
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cerebellar Ataxia ◽  
Hcv Infection ◽  
Acid Decarboxylase ◽  
High Dose ◽  
Hepatitis C Infection ◽  
Extrahepatic Manifestation ◽  
Immunoglobulin Treatment ◽  
Rule Out

Extrahepatic immunological manifestations of hepatitis C virus (HCV) are well described. In addition, antiglutamic acid decarboxylase (GAD) antibody-associated cerebellar ataxia is well-established entity. However, there have been no reports in the literature of anti-GAD antibody-associated ataxia as an extrahepatic manifestation of HCV infection. We report the case of a young woman with chronic hepatitis C virus and multiple extrahepatic autoimmune diseases including Sjögren syndrome and pernicious anemia who presented with subacute midline cerebellar syndrome and was found to have positive antiglutamic acid decarboxylase (GAD) antibody in the serum and cerebrospinal fluid. An extensive diagnostic workup to rule out neoplastic growths was negative, suggesting the diagnosis of nonparaneoplastic antiglutamic acid decarboxylase antibody-associated cerebellar ataxia as an additional extrahepatic manifestation of hepatitis C virus infection. The patient failed to respond to high-dose steroids and intravenous immunoglobulin. Treatment with the monoclonal antibody rituximab stabilized the disease. We postulate that anti-GAD associated ataxia could be an extrahepatic manifestation of HCV infection.

scholarly journals Association of Peripheral Neuropathy in Hepatitis C Infection with and without Cryoglobulineamia

2021 ◽  
Vol 15 (8) ◽  
pp. 2487-2490
Author(s):  
Asmat Ullah ◽  
Mirwais Kakar ◽  
Bilal Ahmed ◽  
Sadia Jabbar ◽  
Inayat Ullah
Keyword(s):  
Hepatitis C ◽  
Peripheral Neuropathy ◽  
Peripheral Nerve ◽  
Nerve Biopsy ◽  
Cross Sectional Study ◽  
Sural Nerve Biopsy ◽  
Cranial Neuropathy ◽  
Hepatitis C Infection ◽  
Cross Sectional ◽  
Peripheral Nerve Involvement

Objective: The purpose of this study was to find out the association of peripheral neuropathy in hepatitis C infection with and without cryoglobulineamia. Study Design: Cross sectional study Place and Duration: Conducted in Liver Transplant Unit, Gambat Institute of Medical Sciences, Gambat Khairpur Mirs, Sindh for the duration of six months from November 2020 to April 2021. Methods: Total 50 patients who had hepatitis C infection and peripheral neuropathy were included in this study. Patients were aged between 18- 60 years. Detailed demographics of patients including age, sex and body mass index were recorded after taking informed written consent. When symptoms and evidence of peripheral sensory or motor involvement were evident, clinical neuropathy was diagnosed. Sural nerve biopsy was done on patients and the biopsy specimen was evaluated morphologically and morphometrically. Multiple neuropathy, cranial neuropathy, and polyneuropathy are all terms used to describe peripheral nerve involvement. Our research focused on the motor conduction of the median, ulnar, and common peroneal nerves, measuring MCV, CMAP amplitude, and distal latency (DL) in both patients with and without cryoglobulinaemia for each nerve. The SPSS 20.0 version was used to analyze the data. Results: Mean age of the patients was 46.23±9.87 years with mean BMI 29.16±11.27 kg/m2. There were 30 (60%) females and 20 (40%) were males. We found that 35 (70%) patients had CG involvement with peripheral neuropathy and 15 (30%) cases were without CG. Prevalence of polyneuropathy was higher 19 (54.3%) in CG patients as compared to non CG 2 (13.3%). Mononeuropathy or multiple neuropathy was higher in HCV CG patients 13 (37.1%) as compared to HCV non CG patients 4 (26.7%). 25 patients underwent nerve biopsy (20 CG patients and 5 non CG). Prevalence of epineurial vasculitis and fascicular loss of axons was higher in non CG patients while demyelination + axonal degeneration were prevalent in CG patients. MCV of the deep peroneal nerve in patients with CG+ was low as compared to CG. Even though no statistically significant differences were detected, the other neurophysiological measures pointed to a more extensive and severe involvement of peripheral nerve in CG+ patients. Conclusion: We concluded in this study that the association of peripheral neuropathy in HCV patients with cryoglobulinaemia was greater as compared to non-CG HCV patients. It appears that both CG+ and CG patients suffer from peripheral nerve injury via a vasculitic mechanism, as evidenced by clinical and morphological observations. Serum CG levels indicate a more severe and broad neuropathic involvement, however research suggests that cryoglobulins are not the only element in the vasculitic process. Keywords: Cryoglobulinemia, Peripheral Neuropathy, HCV

scholarly journals Extrahepaticus manifesztációk idült hepatitis C-vírus-fertőzöttekben

2017 ◽  
Vol 158 (16) ◽  
pp. 603-611
Author(s):  
Krisztina Hagymási ◽  
Anna Egresi ◽  
Gabriella Lengyel
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Antiviral Agents ◽  
Extrahepatic Manifestations ◽  
Hepatitis C Infection ◽  
Extrahepatic Manifestation ◽  
Direct Antiviral Agents

Abstract: The importance of chronic hepatitis C infection is significant. 3% of the World’s population is infected. There is at least one extrahepatic manifestation in 50% of HCV patients, which makes the prognosis and mortality worse. The pathomechanisms included are cryoglobulin production, immunmechanisms, and direct viral effects. The authors summarize the main extrahepatic manifestations, as well as treatment possibilities. The aim is to draw attention to this colourful infection in order to improve the recognition in the era of the new effective direct antiviral agents. Orv. Hetil., 2017, 158(16), 603–612.

PO32-FR-21 Peripheral neuropathy in viral hepatitis C infection without cryoglobulinemia: five case reports

2009 ◽  
Vol 285 ◽  
pp. S332
Author(s):  
M.A. Rafai ◽  
F.Z. Boulaajaj ◽  
A. Bendahmane ◽  
I. Gam ◽  
R. Alaoui ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Peripheral Neuropathy ◽  
Viral Hepatitis ◽  
Case Reports ◽  
Hepatitis C Infection ◽  
Viral Hepatitis C
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