Genetic, Risk Factors, Pathogenesis and Systemic Diseases in Retinal Artery Occlusion

Retinal artery occlusions ( RAO) are considered an ocular emergency.  It has been estimated to occur with a frequency of about one per 10,000 outpatient visits. It is usually seen over the sixties and can be seen in younger age groups. Retinal artery occlusions are not hereditary diseases but can develop secondary to some hereditary diseases. The most important risk factors for RAO include smoking, oral contraceptive use, pregnancy, antiphospholipid syndrome, hyperhomocysteinemia, acquired protein c deficiency. RAO usually develops due to embolism. Embolic sources are mostly carotid arteries or cardiac origin. RAO is associated with many systemic diseases. The most important of these diseases are HT, DM, cardiovascular diseases, renal diseases, and temporal (giant cell) arteritis.

Author(s):  
Shivcharan Lal Chandravanshi, Sunil Kumar Shrivastava, Priyanka Agnihotri, Smriti Gupta

Aims and Objective - The aim of the present study is to identify risk factors associated with different retinal vascular occlusive diseases (RVOD), such as central retinal artery occlusion (CRAO), hemi-retinal artery occlusion (HRAO), branch retinal artery occlusion (BRAO), cilioretinal artery occlusion (Cilio-RAO), central retinal vein occlusion (CRVO), branch retinal vein occlusion (BRVO), and hemi-retinal vein occlusion (HRVO). Patients and Method - A cross-sectional study on 114 consecutive subjects, aged 24-96 years who have attended at the outpatient department of ophthalmology at Shyam Shah Medical College, Rewa, MP, were included in the study. The Duration of study was January 2016 to December 2017. Only patients with CRAO, BRAO, HRAO, Cilio-RAO, CRVO, BRVO, and HRVO were included in the study. Other retinal vascular disorders such as diabetic vaso-occlusive disease, anterior and posterior ischemic and non-ischemic neuropathy, hypertensive retinopathy, sickle cell retinopathy, retinal telangiectasia, retinopathy of prematurity, were excluded from study. Results - We have included 114 patients, 64 cases (56.14%) males, 50 (43.85%) females, aged 56+/-8 years (range 24-96 years).  Bilateral retinal vascular occlusive disorders were seen in only 4 cases (3.5%). Two patients have bilateral CRVO followed by one case of bilateral BRVO and one case of bilateral CRAO.  Out of 114 patients, branch retinal vein occlusion was seen in 62 cases (54.38%), followed by central retinal vein occlusion in 36 cases (31.57%), CRAO in 8 cases (7.01%), and hemi- retinal vein occlusion in 4 cases (3.50%). Hypertension was the most common, (40 cases, 35.08%) risk factor identified for retinal vascular occlusive disorders followed by diabetes 24 cases (21.05%), combined diabetes and hypertension in 22 cases (19.29%), and atherosclerosis in 18 cases (15.78%). Conclusions - Retinal vascular occlusive diseases have systemic as well as ocular risk factors. Understanding of these risk factors is essential for proper treatment of RVOD. Timely identification of risk factors for RVOD may helpful in decreasing ocular and systemic morbidity in these patients.


2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Grayson Roumeliotis ◽  
Stewart Campbell ◽  
Sumit Das ◽  
Goran Darius Hildebrand ◽  
Peter Charbel Issa ◽  
...  

2019 ◽  
Vol 200 ◽  
pp. 271-272 ◽  
Author(s):  
Patrick Lavin ◽  
Morgan Patrylo ◽  
Matthew Hollar ◽  
Kiersten B. Espaillat ◽  
Howard Kirshner ◽  
...  

2018 ◽  
Vol 196 ◽  
pp. 96-100 ◽  
Author(s):  
Patrick Lavin ◽  
Morgan Patrylo ◽  
Matthew Hollar ◽  
Kiersten B. Espaillat ◽  
Howard Kirshner ◽  
...  

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142852 ◽  
Author(s):  
Seong Joon Ahn ◽  
Kyu Hyung Park ◽  
Na-Kyung Ryoo ◽  
Jeong-Ho Hong ◽  
Cheolkyu Jung ◽  
...  

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Hashim Khan ◽  
Morad Chughtai ◽  
Ahmed A Malik ◽  
Adnan I Qureshi ◽  
Fareed K Suri

Objective: To determine the rate of and risk factors for incident central retinal artery occlusion (CRAO) among patients with sickle cell disease enrolled in a large cohort with longitudinal follow-up. Background: Sickle cell disease increases the risk of ischemic stroke among women but the risk of CRAO is not studied. Design/Methods: A total of 4085 patients from newborns to 77 years-old, were enrolled in Phase 1 of Cooperative Study of Sickle Cell Disease from 23 centers across the US. Participants underwent a baseline examination for assessment of demographics, prior medical history, lab assessments, and clinical data. Post baseline data included routine follow-up examinations, measures of organ damage, and collection of acute and chronic complications. The risk factors for CRAO were identified using Cox Proportional Hazards analysis. Results: A total of 9 (0.002%) of 4085 patients with sickle cell disease developed CRAO over a mean follow-up of 5.2 (95% CI 0.9 - 11.3) months, with an estimated incidence of 0.02 per 100 patient years. The incidence of CRAO was 0.03 per 100 patient years and 0.05 per 100 patient years in men and women, respectively. The history of previous stroke (2.6% versus 0.0%, p=0.7) and the proportion of patients diagnosed with large arterial occlusive disease (55.6% versus 7.7%, p=<0.001) was greater in those who developed CRAO compared to those who did not develop CRAO. History of exchange transfusions (2.7 % versus 22.2 %, p=0.02) and cigarette smoking (13.7 % versus 22.2 %, p =0.4) were more common among patients who developed CRAO. The hematocrit (%) (mean ± SD) was similar between patients who did or did not develop CRAO (29.5 ± 9.6 versus 27.3 ± 5.6, p=0.3). At completion of follow-up, 22.2% (n=2) patients with CRAO reported disability compared with 11.1% (n=455) patients without CRAO (p=0.7) Conclusions: The incidence of CRAO is relatively high among patients with sickle cell disease and was associated with disability.


2007 ◽  
Vol 18 (4) ◽  
pp. 321-326 ◽  
Author(s):  
Rossella Marcucci ◽  
Andrea Sodi ◽  
Barbara Giambene ◽  
Agatina Alessandrello Liotta ◽  
Daniela Poli ◽  
...  

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Jessica Ruzicki ◽  
Eric K. Chin ◽  
David Almeida

Branch retinal artery occlusion (BRAO) is typically associated with irreversible vision and peripheral visual field loss. We report a case of a 62-year-old woman with a BRAO related to several cardiovascular risk factors. Our patient encountered gradual but significant vision recovery months following carotid artery endarterectomy for carotid stenosis.


Sign in / Sign up

Export Citation Format

Share Document