Optical Coherence Tomography in Vitreoretinal Interface Disorders

2018 ◽  
pp. 236-243
Keyword(s):  
Optical Coherence Tomography ◽  
Time Domain ◽  
Treatment Modalities ◽  
Optical Coherence ◽  
Vitreoretinal Interface ◽  
Swept Source ◽  
Appearance Time ◽  
Swept Source Oct ◽  
New Treatment ◽  
Pathologic Processes

Optical coherence tomography (OCT), which is in use for about 20 years, facilitated the evaluation of the vitreoretinal interface, improved our understanding of its pathologic processes, and paved the way to new treatment approaches. By order of appearance, time-domain, spectral-domain, and swept-source OCT technologies redefined vitreoretinal interface disorders and their treatment modalities.

scholarly journals Extratympanic Observation of Middle and Inner Ear Structures in Rodents Using Optical Coherence Tomography

2020 ◽  
Vol 13 (2) ◽  
pp. 106-112 ◽  
Author(s):  
Se-Joon Oh ◽  
Il-Woo Lee ◽  
Soo-Geun Wang ◽  
Soo-Keun Kong ◽  
Hong-Ki Kim ◽  
...  
Keyword(s):  
Animal Model ◽  
Optical Coherence Tomography ◽  
Inner Ear ◽  
Oval Window ◽  
Diagnostic Information ◽  
Optical Coherence ◽  
Swept Source ◽  
Diagnostic Technology ◽  
Swept Source Oct ◽  
Rats And Mice

Objectives. This study aimed to investigate whether optical coherence tomography (OCT) provides useful information about the microstructures of the middle and inner ear via extratympanic approach and thereby could be utilized as an alternative diagnostic technology in ear imaging.Methods. Five rats and mice were included, and the swept-source OCT system was applied to confirm the extent of visibility of the middle and inner ear and measure the length or thickness of the microstructures in the ear. The cochlea was subsequently dissected following OCT and histologically evaluated to compare with the OCT images.Results. The middle ear microstructures such as ossicles, stapedial artery and oval window through the tympanic membrane with the OCT could be confirmed in both rats and mice. It was also possible to obtain the inner ear images such as each compartment of the cochlea in the mice, but the bone covering bulla needed to be removed to visualize the inner ear structures in the rats which had thicker bulla. The bony thickness covering the cochlea could be measured, which showed no significant differences between OCT and histologic image at all turns of cochlea.Conclusion. OCT has been shown a promising technology to assess real-time middle and inner ear microstructures noninvasively with a high-resolution in the animal model. Therefore, OCT could be utilized to provide additional diagnostic information about the diseases of the middle and inner ear.

A NEW AND MODERN DIGNOSTIC TECHNIQUE: SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY (SS-OCT)

2013 ◽  
Vol 5 (2) ◽  
pp. 31-33
Author(s):  
Prakash Lokhande
Keyword(s):  
Optical Coherence Tomography ◽  
High Resolution ◽  
Optical Imaging ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Swept Source ◽  
Non Invasive ◽  
Treatment Technologies ◽  
High Resolution Images ◽  
Swept Source Oct

ABSTRACT Innovative technique has been introduced in the field of dentistry for the purpose of diagnosis and treatment. Technologies like laser, composite curing techniques, optical imaging have been utilized in the field of dentistry. OCT(optical coherence tomography) is a recent. technique which creates cross-sectional high resolution images. SS-OCT(Swept -Source optical coherence tomography) is a variant of optical coherence tomography, which provides instant imaging with high resolution, non-invasive and ease of handling. This article provides a overview of Swept -Source OCT and its application in the field of dentistry.

scholarly journals Evaluating posterior vitreous detachment by widefield 23-mm swept-source optical coherence tomography imaging in healthy subjects

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yoshiaki Chiku ◽  
Takao Hirano ◽  
Yoshiaki Takahashi ◽  
Ayako Tuchiya ◽  
Marie Nakamura ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Healthy Subjects ◽  
Posterior Vitreous Detachment ◽  
Internal Limiting Membrane ◽  
Optical Coherence ◽  
Swept Source ◽  
Vitreous Detachment ◽  
Swept Source Oct ◽  
B Scan Images ◽  
Sd Oct

AbstractPosterior vitreous detachment (PVD) is a separation between the posterior vitreous cortex and internal limiting membrane. Although PVD was historically considered an acute event, recent studies using spectral-domain optical coherence tomography (SD-OCT) revealed a gradual progression of PVD in healthy subjects. Although SD-OCT improved PVD studies, the narrow imaging angle and long examination time were problematic to allow wide angle capture. The Xephilio OCT-S1 (Canon), a swept-source OCT (SS-OCT) device, can obtain up to 23-mm of widefield B-scan images in a single acquisition. We used this widefield SS-OCT to quantitatively evaluate the PVD stage in 214 healthy subjects aged 4–89 years and determine whether PVD stages differ between the bilateral eyes of each patient. Age was significantly positively correlated with the overall PVD stage (ρ = 0.7520, P < 0.001). Interestingly, partial PVD occurred in children as young as 5 years, indicating that initial PVD onset may occur much earlier than previously reported. Furthermore, PVD stages of the bilateral eyes were highly consistent in 183 subjects (85.5%). Widefield 23-mm SS-OCT thus revealed that PVD started earlier than anticipated, and age was correlated with the symmetry of PVD stage. Widefield 23-mm SS-OCT may also be clinically useful for the evaluation of diseased eyes.

scholarly journals Angiography with optical coherence tomography as a biomarker in multiple sclerosis

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243236
Author(s):  
Beatriz Cordon ◽  
Elisa Vilades ◽  
Elvira Orduna ◽  
María Satue ◽  
Javier Perez-Velilla ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optical Coherence Tomography ◽  
Healthy Subjects ◽  
Optical Coherence ◽  
Swept Source ◽  
Retinal Microvasculature ◽  
Potential Biomarker ◽  
Relapsing Remitting ◽  
Swept Source Oct ◽  
Retinal Vascularization

Purpose To investigate superficial retinal microvascular plexuses detected by optical coherence tomography angiography (OCT-A) in multiple sclerosis (MS) subjects and compare them with healthy controls. Methods A total of 92 eyes from 92 patients with relapsing-remitting MS and 149 control eyes were included in this prospective observational study. OCT-A imaging was performed using Triton Swept-Source OCT (Topcon Corporation, Japan). The vessel density (VD) percentage in the superficial retinal plexus and optic disc area (6 x 6 mm grid) was measured and compared between groups. Results MS patients showed a significant decrease VD in the superior (p = 0.005), nasal (p = 0.029) and inferior (p = 0.040) parafoveal retina compared with healthy subjects. Patients with disease durations of more than 5 years presented lower VD in the superior (p = 0.002), nasal (p = 0.017) and inferior (p = 0.022) parafoveal areas compared with healthy subjects. Patients with past optic neuritis episodes did not show retinal microvasculature alterations, but patients with an EDSS score of less than 3 showed a significant decrease in nasal (p = 0.024) and superior (p = 0.006) perifoveal VD when compared with healthy subjects. Conclusions MS produces a decrease in retinal vascularization density in the superficial plexus of the parafoveal retina. Alterations in retinal vascularization observed in MS patients are independent of the presence of optic nerve inflammation. OCT-A has the ability to detect subclinical vascular changes and is a potential biomarker for diagnosing the presence and progression of MS.

scholarly journals Evaluating Posterior Vitreous Detachment By Widefield 23-mm Swept-Source Optical Coherence Tomography Imaging In Healthy Subjects

2021 ◽  
Author(s):  
Yoshiaki Chiku ◽  
Takao Hirano ◽  
Yoshiaki Takahashi ◽  
Ayako Tuchiya ◽  
Marie Nakamura ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Healthy Subjects ◽  
Posterior Vitreous Detachment ◽  
Internal Limiting Membrane ◽  
Optical Coherence ◽  
Swept Source ◽  
Vitreous Detachment ◽  
Swept Source Oct ◽  
B Scan Images ◽  
Sd Oct

Abstract Posterior vitreous detachment (PVD) is a separation between the posterior vitreous cortex and internal limiting membrane. Although PVD was historically considered an acute event, recent studies using spectral-domain optical coherence tomography (SD-OCT) revealed a gradual progression of PVD in healthy subjects. Although SD-OCT improved PVD studies, the narrow imaging angle and long examination time were problematic to allow wide angle capture. The Xephilio OCT-S1 (Canon), a swept source OCT (SS-OCT) device, can obtain up to 23-mm of widefield B-scan images in a single acquisition. We used this widefield SS-OCT to quantitatively evaluate the PVD stage in 214 healthy subjects aged 4–89 years and determine whether PVD stages differ between the bilateral eyes of each patient. Age was significantly positively correlated with overall PVD stage (ρ=0.7520, P<0.001). Interestingly, partial PVD occurred in children as young as 5 years old, indicating that initial PVD onset may occur much earlier than previously reported.Furthermore, PVD stages of the bilateral eyes were highly consistent in 183 subjects (85.5%). Widefield 23-mm SS-OCT thus revealed that PVD started earlier than anticipated, and age is correlated with the symmetry of PVD stage. Widefield 23-mm SS-OCT may also be clinically useful for the evaluation of diseased eyes.

Detection of neovascularisation in the vitreoretinal interface slab using widefield swept-source optical coherence tomography angiography in diabetic retinopathy

2020 ◽  
pp. bjophthalmol-2020-317983
Author(s):  
Edward S Lu ◽  
Ying Cui ◽  
Rongrong Le ◽  
Ying Zhu ◽  
Jay C Wang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Optic Disc ◽  
Proliferative Diabetic Retinopathy ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Vitreoretinal Interface ◽  
Cross Sectional ◽  
Swept Source ◽  
Detection Rates

AimsTo compare the efficacy of diabetic retinal neovascularisation (NV) detection using the widefield swept-source optical coherence tomography angiography (WF SS-OCTA) vitreoretinal interface (VRI) Angio slab and SS-OCT VRI Structure slab.MethodsA prospective, observational study was performed at Massachusetts Eye and Ear from January 2019 to June 2020. Patients with proliferative diabetic retinopathy (PDR), patients with non-proliferative diabetic retinopathy and patients with diabetes but without diabetic retinopathy were included. All patients were imaged with WF SS-OCTA using the 12×12 mm Angio scan protocol centred on the fovea and optic disc. The en-face SS-OCTA VRI Angio slab and SS-OCT VRI Structure slab were evaluated for the presence or absence of NV. SS-OCTA B-scan was used to classify NV according to cross-sectional morphology (forward, tabletop or flat). All statistical analyses were performed using SPSS V.26.0.ResultsOne hundred and forty-two eyes of 89 participants were included in the study. VRI Angio detected NV at higher rates compared with VRI Structure (p<0.05). Combining VRI Angio and Structure improved detection rates compared with VRI Angio alone (p<0.05). Due to segmentation errors of the internal limiting membrane, NV with flat morphological classification had lower rates of detection on VRI Angio compared with NV with forward and tabletop morphology (p<0.05).ConclusionsWF SS-OCTA 12×12 mm VRI Angio and SS-OCT VRI Structure imaging centred on the fovea and optic disc detected NV with high sensitivity and low false positives. The VRI slab may be useful to diagnose and monitor PDR in clinical practice.

scholarly journals Determination of Referential Rates for Optical Coherence Tomography and Optical Coherence Tomography Angiography Flow Deficits in the Macular Choriocapillaris in Ophthalmologically Healthy Children

Medicina ◽  
2020 ◽  
Vol 56 (5) ◽  
pp. 238
Author(s):  
Viktorija Bakstytė ◽  
Liveta Šniurevičiūtė ◽  
Evelina Šimienė ◽  
Justina Skruodytė ◽  
Ingrida Janulevičienė
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Healthy Children ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Swept Source ◽  
Rnfl Thickness ◽  
Swept Source Oct ◽  
New Research

Background and Objectives: Despite the growing number of new research publications, normative references for children’s optical coherence tomography (OCT) parameters are still not completed. We chose to explore this topic because of the lack of normative parameters that is due to an improvement in different technologies and instruments. Our aim was to determine referential rates of retinal nerve fiber layer (RNFL) thickness and flow deficits (FD%) in the macular choriocapillaris (CC) in normal eyes of ophthalmologically healthy children. Materials and Methods: Ophthalmologically healthy 8- to 14-year-old individuals participated (n = 75) in this study. OCT images were taken using an swept-source-OCT (SS-OCT) instrument (DRI-OCT Triton, Topcon, Tokyo, Japan). The early treatment diabetic retinopathy study (EDTRS) grid (6 × 6 mm) divided the RNFL into the thickness maps. The FD% values of the CC were calculated on the 3 × 3-mm scans in a 1-mm circle (C1), 1.5-mm rim (R1.5), and the entire 2.5-mm circle (C2.5), and on the 6 x 6-mm scans in a 1-mm circle (C1), 1.5-mm rim (R1.5), the entire 2.5-mm circle (C2.5), 2.5-mm rim (R2.5), and 5-mm circle (C5). Results: Both scan quantifications of FD% in the C1, C2.5, and R1.5 sectors were similar, but the 6 × 6-mm scan measurements were statistically significantly smaller than the 3 × 3-mm ones. Significant moderate correlations were found between axial length (AxL) and FD% in the 6 × 6-mm scans, namely C1 (r = −0.347, p = 0.002), C2.5 (r = −0.337, p = 0.003), R1.5 (r = −0.328, p = 0.004), R2.5 (r = −0.306, p = 0.008), and C5 (r = −0.314, p = 0.006). Conclusions: The thinnest RNFL layers were on the temporal and nasal sides. FD% values in the C1, C2.5, and R1.5 sectors were similar between the 3 × 3-mm and 6 × 6-mm scans. The negative moderate correlations between AxL and FD% were found in all C1, C2.5, C5, R1.5, and R2.5 sectors of the 6 × 6-mm scans. Further prospective studies are needed to determine more accurate normative references for children’s OCT parameters.

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