Effects of Discrimination Task Difficulty on N1 and P2 Components of Late Auditory Evoked Potential

2004 ◽  
Vol 15 (06) ◽  
pp. 456-461 ◽  
Author(s):  
Jerry L. Cranford ◽  
Amy K. Rothermel ◽  
Letitia Walker ◽  
Andrew Stuart ◽  
Saravanan Elangovan
Keyword(s):  
Auditory Processing ◽  
Task Difficulty ◽  
Discrimination Task ◽  
Evoked Potential ◽  
Auditory Evoked Potential ◽  
Objective Evidence ◽  
Tonal Stimuli ◽  
Competing Speech ◽  
Selective Effects

The present study investigated the question of whether, in healthy young listeners, increases in discrimination task difficulty will alter the amplitude of either the N1 or P2 components of the late auditory evoked potential (LAEP). Using a stimulus oddball procedure, listeners discriminated changes in the frequency of ongoing tonal stimuli. On different test runs, task difficulty was manipulated by decreasing the size of the frequency differences and/or adding competing speech babble to the nontest ear. Both stimulus procedures produced significant decreases in P2 amplitude but had no effects on N1 amplitudes. This finding of selective effects on later rather than earlier occurring components of the LAEP provides objective evidence that some forms of auditory processing are mediated at more central levels of the system.

Interaction of estrogen with central serotonergic mechanisms in human sensory processing: loudness dependence of the auditory evoked potential and mismatch negativity

2010 ◽  
Vol 25 (12) ◽  
pp. 1614-1622 ◽  
Author(s):  
Valérie Guille ◽  
Andrea Gogos ◽  
Pradeep J Nathan ◽  
Rodney J Croft ◽  
Maarten van den Buuse
Keyword(s):  
Auditory Processing ◽  
Mismatch Negativity ◽  
Repeated Measures ◽  
Evoked Potential ◽  
Partial Agonist ◽  
Auditory Evoked Potential ◽  
Double Blind ◽  
Repeated Measures Design ◽  
Loudness Dependence ◽  
Pre Treatment

Estrogen may be involved in schizophrenia by inhibiting serotonin-1A (5-HT1A) receptor function. We examined the effects of estrogen pre-treatment on modulation of loudness dependence of the auditory evoked potential (LDAEP) and mismatch negativity by the 5-HT1A receptor partial agonist, buspirone. Using a double-blind, placebo-controlled, repeated-measures design in healthy female volunteers, we observed that buspirone treatment significantly increased LDAEP slope. Estrogen increased LDAEP slope on its own, and a further LDAEP increase by buspirone was not seen after estrogen pre-treatment. Similar results were observed for mismatch negativity, where buspirone caused a small increase of latency, although not amplitude, after placebo but not estrogen pre-treatment, which enhanced mismatch negativity latency on its own. These results are in line with our previous findings on prepulse inhibition showing an inhibitory effect of estrogen on the action of buspirone. Taken together, these data suggest that estrogen may inhibit 5-HT1A receptor-mediated disruptions of auditory processing.

scholarly journals Test-Retest of Long Latency Auditory Evoked Potentials (P300) with Pure Tone and Speech Stimuli

2016 ◽  
Vol 21 (02) ◽  
pp. 134-139 ◽  
Author(s):  
Ana Perez ◽  
Karin Ziliotto ◽  
Liliane Pereira
Keyword(s):  
Evoked Potentials ◽  
Auditory Processing ◽  
Pure Tone ◽  
Auditory Evoked Potentials ◽  
Evoked Potential ◽  
Auditory Evoked Potential ◽  
Speech Stimulus ◽  
P300 Latency ◽  
Speech Stimuli ◽  
Long Latency

Introduction Long latency auditory evoked potentials, especially P300, have been used for clinical evaluation of mental processing. Many factors can interfere with Auditory Evoked Potential - P300 results, suggesting large intra and inter-subject variations. Objective The objective of the study was to identify the reliability of P3 components (latency and amplitude) over 4–6 weeks and the most stable auditory stimulus with the best test-retest agreement. Methods Ten normal-hearing women participated in the study. Only subjects without auditory processing problems were included. To determine the P3 components, we elicited long latency auditory evoked potential (P300) by pure tone and speech stimuli, and retested after 4–6 weeks using the same parameters. We identified P300 latency and amplitude by waveform subtraction. Results We found lower coefficient of variation values in latency than in amplitude, with less variability analysis when speech stimulus was used. There was no significant correlation in latency measures between pure tone and speech stimuli, and sessions. There was a significant intrasubject correlation between measures of latency and amplitude. Conclusion These findings show that amplitude responses are more robust for the speech stimulus when compared with its pure tone counterpart. The P300 indicated stability for latency and amplitude measures when the test-retest was applied. Reliability was higher for amplitude than for latency, with better agreement when the pure tone stimulus was used. However, further research with speech stimulus is needed to clarify how these stimuli are processed by the nervous system.

scholarly journals Auditory evoked potential (P300) in cochlear implant users: a scoping review

2020 ◽  
Author(s):  
Maria Stella Arantes do Amaral ◽  
Nelma Ellen Zamberlan-Amorin ◽  
Karina Dal Sasso Mendes ◽  
Sarah Carolina Bernal ◽  
Eduardo Tanaka Massuda ◽  
...  
Keyword(s):  
Cochlear Implant ◽  
Scoping Review ◽  
Auditory Processing ◽  
Evoked Potential ◽  
Web Of Science ◽  
Scientific Evidence ◽  
Auditory Evoked Potential ◽  
Invasive Technique ◽  
Central Auditory Processing ◽  
Lower Amplitude

AbstractIntroductionP300 auditory evoked potential is evoked by a long latency auditory stimulus, which provides information on neural mechanisms underlying central auditory processing, considered an objective and non-invasive technique to study the auditory central nervous system.ObjectiveTo identify and gather scientific evidence regarding the P3 component in adult cochlear implant users.MethodsScoping review of scientific literature, in the search of original articles in Portuguese, Spanish and English, published between 1991 and May 2018, in the following database websites: PubMed / Medline, Embase, LILACS and Web of Science.ResultsA total of 87 articles were identified and exported to the search software Rayyan for study selection - 58 were from Embase, 26 from PubMed and 3 from Web of Science. There were no articles found on LILACS. From those 87 articles, 16 were excluded for being duplicated. Then 71 articles were selected for title, authors, yeas and abstract scanning, from which 50 articles were excluded. From the 21 final articles for full reading, one was excluded for not performing P300, leaving us with 20 selected articles.ConclusionThis review has contributed with evidence that indicates how important it is to include speech stimulation when measuring P300. Regardless of the stimulus being used for P300 elicitation, a pattern of results can be seen a higher latency and a lower amplitude in CI users.

scholarly journals Are evoked potentials clinically useful in the study of patients with Chiari malformation Type 1?

2017 ◽  
Vol 126 (2) ◽  
pp. 606-619 ◽  
Author(s):  
Dulce Moncho ◽  
Maria A. Poca ◽  
Teresa Minoves ◽  
Alejandro Ferré ◽  
Victoria Cañas ◽  
...  
Keyword(s):  
Evoked Potentials ◽  
Chiari Malformation ◽  
Evoked Potential ◽  
Auditory Evoked Potential ◽  
Tonsillar Herniation ◽  
Lower Cranial Nerve ◽  
Objective Evidence ◽  
Neurophysiological Studies ◽  
Chiari Malformation Type 1

OBJECTIVE In this study, the authors describe the brainstem auditory evoked potential (BAEP) and somatosensory evoked potential (SSEP) alterations found in a large cohort of patients with Chiari malformation Type 1 (CM-1), the relationship between the BAEPs/SSEPs and the clinical findings, the abnormalities in patients with associated syringomyelia, and the clinical and neuroradiological risk factors that are associated with abnormal evoked potentials (EPs). METHODS A prospectively collected database containing 545 patients with CM-1 was queried to search for patients satisfying the following criteria: 1) an age of at least 14 years, 2) neuroradiological criteria of CM-1, 3) no prior Chiari-related surgeries, and 4) preoperative EP studies conducted at the authors' institution. The 200 patients included in this cohort were classified into CM-0, CM-1, and CM-1.5 subtypes. Linear, planimetric, and angular measurements of the posterior fossa were conducted, as well as syringomyelia measurements. Two separate multiple logistic regression models were used, one to predict the covariates associated with abnormal BAEPs, and a second model to explore the variables associated with an abnormal SSEP. In these models, the BAEPs and SSEPs were dichotomized as being normal or abnormal. RESULTS Headaches were the main symptom in 70.5% of the patients, and Valsalva-induced headaches were most frequent in patients with CM-1 and CM-1.5 compared with patients with CM-0 (p = 0.031). BAEPs were abnormal in 38.5% of patients, and abnormal SSEPs were found in 43.5% of the entire cohort. Syringomyelia was most frequent in patients with CM-0 (64.3%) and CM-1 (51.1%) compared with those with CM-1.5 (34.7%; p = 0.03). Age (OR 1.03, 95% CI 1.00–1.06), the degree of tonsillar herniation (OR 1.08, 95% CI 1.01–1.16), and lower cranial nerve dysfunction (OR 3.99, 95% CI 1.29–14.01) had a statistically significant correlation with abnormal BAEPs. Only age (OR 1.07, 95% CI 1.04–1.10) and the degree of tonsillar herniation (OR 1.11, 95% CI 1.04–1.19) had a statistically significant correlation with abnormal SSEPs. CONCLUSIONS A high percentage of patients with CM-1 exhibited EP alterations regardless of their clinical or radiological findings. These findings suggest that EPs do not add any clinically relevant information nor are they helpful in establishing which symptomatic patients with CM should undergo surgical treatment. However, BAEP and SSEP studies clearly play an important role in incidentally detected patients with CM and may help to establish objective evidence of subclinical dysfunctions. In addition, neurophysiological studies may help to define subgroups of patients who require further testing and follow-up to personalize strategies for the management of incidental and oligosymptomatic patients.

Cortical Auditory-Evoked Potential and Behavioral Evidence for Differences in Auditory Processing between Good and Poor Readers

2017 ◽  
Vol 28 (06) ◽  
pp. 534-545 ◽  
Author(s):  
Matthew D. Barker ◽  
Abin Kuruvilla-Mathew ◽  
Suzanne C. Purdy
Keyword(s):  
Auditory Processing ◽  
Evoked Potential ◽  
Auditory Evoked Potential ◽  
Poor Readers ◽  
Good Reader ◽  
Behavioral Measures ◽  
Tonal Pattern ◽  
Reader Group ◽  
Good And Poor Readers ◽  
Cortical Auditory Evoked Potential

Background: The relationship between auditory processing (AP) and reading is thought to be significant; however our understanding of this relationship is somewhat limited. Previous studies have investigated the relation between certain electrophysiological and behavioral measures of AP and reading abilities in children. This study attempts to further understand that relation. Purpose: Differences in AP between good and poor readers were investigated using electrophysiological and behavioral measures. Study Sample: Thirty-two children (15 female) aged 9–11 yr were placed in either a good reader group or poor reader group, based on the scores of a nationally normed reading test in New Zealand. Research Design: Children were initially tested using an automated behavioral measuring system that runs through a tablet computer known as “Feather Squadron.” Following the administration of Feather Squadron, cortical auditory-evoked potentials (CAEPs) were recorded using a speech stimulus (/m/) with the HEARLab® Cortical Auditory Evoked Potential Analyzer. Data Collection and Analysis: The children were evaluated on eight subsections of the Feather Squadron, and CAEP waveform peaks were visually identified and averaged. Separate Kruskal–Wallis analyses were performed for the behavioral and electrophysiological variables, with group (good versus poor readers) serving as the between-group independent variable and scores from the Feather Squadron AP tasks as well as CAEP latencies and amplitudes as dependent variables. After the children’s AP status was determined, the entire group was further divided into three groups: typically developing, auditory processing disorder + reading difficulty (APD + RD), and RDs only. Statistical analyses were repeated for these subgroups. Results: Poorer readers showed significantly worse scores than the good readers for the Tonal Pattern 1, Tonal Pattern 2, and Word Double Dichotic Right tasks. CAEP differences observed across groups indicated comorbid effects of RD and AP difficulties. N2 amplitude was significantly smaller for the poor readers. Conclusions: The current study found altered AP in poor readers using behavioral Feather Squadron measures and speech-evoked cortical potentials. These results provide further evidence that intact central auditory function is fundamental for reading development.

scholarly journals Auditory cortex plasticity in musicians

2021 ◽  
Vol 31 (Supplement_2) ◽  
Author(s):  
Cláudia Reis ◽  
Margarida Teixeira
Keyword(s):  
Auditory Cortex ◽  
Auditory Processing ◽  
Evoked Potential ◽  
Auditory Evoked Potential ◽  
Cortical Inhibition ◽  
Control Group ◽  
Average Amplitude ◽  
Inhibition Effect ◽  
Long Latency ◽  
The Right

Abstract Background The objective of this study was to verify wether it was possible to observe greater plasticity of the auditory cortex and greater benefits in terms of auditory processing, better discrimination, attention and identification of rare stimuli, in musicians, verified through the performance of Long Latency Auditory Evoked Potential, P300, with and without competitive noise, in musicians compared to non-musician. Methods 20 individuals were divided into two groups: 8 in the musicians, and 12 in the control group. The P300 values were compared between the two groups and then between the results of the P300 with and without competitive noise, in both groups. Results When comparing the results without competitive noise, it appears that the average amplitude was higher in the group of musicians compared to the control group, in both ears. Latency was lower in the control group, only in the right ear. With competitive noise, in both groups, the average amplitude is lower, compared to the results of the P300 without competitive noise, both in the right ear and in the left ear, and this effect is more considerable in the group of musicians. Regarding latency, theaverage of the P300 with competitive noise, in both ears, with a greater increase in latency values, in the group of musicians. Conclusion Musicians show a greater cortical inhibition effect compared to non-musicians, demonstrating that the musician’s central auditory system shows greater activation, which can result in better performance in functions such as attention and discrimination, due to training by musical practice.

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