scholarly journals Alternaric acid: formal synthesis and related studies

2013 ◽  
Vol 9 ◽  
pp. 166-172 ◽  
Author(s):  
Michael C Slade ◽  
Jeffrey S Johnson
Keyword(s):  
Natural Product ◽  
Complex Molecule ◽  
Synthetic Route ◽  
Formal Synthesis ◽  
Silyl Glyoxylates ◽  
Unique Approach ◽  
Alternaric Acid ◽  
Three Component Coupling

A silyl glyoxylate three-component-coupling methodology has been exploited to achieve a formal synthesis, an analogue to an intermediate in a distinct formal synthetic route, and a third (unique) approach to the natural product alternaric acid. Highlighted in this study is the versatility of silyl glyoxylates to engage a variety of nucleophile and electrophile pairs to provide wide latitude in the approach to complex molecule synthesis.

A One-Pot Chemoenzymatic Synthesis of (2S,4R)-4-Methylproline Enables the First Total Synthesis of Antiviral Lipopeptide Cavinafungin B

2018 ◽  
Author(s):  
Christian R. Zwick ◽  
Hans Renata
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Complex Molecule ◽  
Molecular Target ◽  
Chemoenzymatic Synthesis ◽  
General Strategy ◽  
One Pot

We report an efficient ten-step synthesis of antiviral natural product cavinafungin B in 37% overall yield. By leveraging a one-pot chemoenzymatic synthesis of (2S,4R)-4-methylproline and oxazolidine-tethered (Rink-Boc-ATG-resin) SPPS methodology, the assembly of our molecular target could be conducted in an efficient manner.This general strategy could prove amenable to the construction of other natural and unnatural linear lipopeptides. The value of incorporating biocatalytic steps in complex molecule synthesis is highlighted by this work.

scholarly journals Development of a Robust Cytopathic Effect-Based High-Throughput Screening Assay To Identify Novel Inhibitors of Dengue Virus

2012 ◽  
Vol 56 (6) ◽  
pp. 3399-3401 ◽  
Author(s):  
Kevin D. McCormick ◽  
Shufeng Liu ◽  
Jana L. Jacobs ◽  
Ernesto T. A. Marques ◽  
Nicolas Sluis-Cremer ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Natural Product ◽  
High Throughput ◽  
High Throughput Screening ◽  
Cytopathic Effect ◽  
Complex Molecule ◽  
Denv Infection ◽  
Screening Assay ◽  
High Throughput Screening Assay ◽  
Natural Product Library

ABSTRACTWe have developed a robust cytopathic effect-based high-throughput screening assay to identify inhibitors of dengue virus (DENV) infection. Screening of a small natural product library yielded 11 hits. Four of these were found to be potent inhibitors of DENV, although serotype differences were noted. Taken together, these data suggest that screening of larger and more complex molecule libraries may result in the identification of more potent and specific DENV inhibitors.

Facile Access to 3,4-Disubstituted 2H-Chromenes via Domino [4+2] Annulation

Synthesis ◽  
2020 ◽  
Author(s):  
Sure Siva Prasad ◽  
Dirgha Raj Joshi ◽  
Ikyon Kim
Keyword(s):  
Lewis Acid ◽  
Triethyl Phosphite ◽  
Synthetic Route ◽  
One Pot ◽  
Highly Efficient ◽  
Three Component Coupling

AbstractA highly efficient synthetic route to polysubstituted 2H-chromenes was developed utilizing a domino O-alkylation/intramolecular Horner–Wadsworth–Emmons (HWE) olefination of diarylmethylphosphonates, which were readily accessed via Lewis acid mediated one-pot three-component coupling of aldehydes, phenols, and triethyl phosphite.

Total synthesis of PGF2α and 6,15-diketo-PGF1α and formal synthesis of 6-keto-PGF1α via three-component coupling

Tetrahedron ◽  
2019 ◽  
Vol 75 (42) ◽  
pp. 130593
Author(s):  
Taehyeong Kim ◽  
Sung Il Lee ◽  
Sejin Kim ◽  
Su Yong Shim ◽  
Do Hyun Ryu
Keyword(s):  
Total Synthesis ◽  
Formal Synthesis ◽  
Three Component Coupling

A synthetic route to 11-(1H-pyrrol-1-yl)-11H-indeno[1,2-b]quinoxaline derivatives exploiting a three-component coupling strategy under microwave irradiation

2005 ◽  
Vol 46 (36) ◽  
pp. 6155-6157 ◽  
Author(s):  
Javad Azizian ◽  
Ali Reza Karimi ◽  
Zahra Kazemizadeh ◽  
Ali A. Mohammadi ◽  
Mohammad R. Mohammadizadeh
Keyword(s):  
Microwave Irradiation ◽  
Synthetic Route ◽  
Quinoxaline Derivatives ◽  
Coupling Strategy ◽  
Three Component Coupling

Semi-synthesis and proteasome inhibition of D-ring deoxy analogs of (–)-epigallocatechin gallate (EGCG), the active ingredient of green tea extract

2008 ◽  
Vol 86 (6) ◽  
pp. 495-502 ◽  
Author(s):  
Congde Huo ◽  
Guoqing Shi ◽  
Wai Har Lam ◽  
Di Chen ◽  
Quizhi Cindy Cui ◽  
...  
Keyword(s):  
Natural Product ◽  
Green Tea ◽  
Epigallocatechin Gallate ◽  
Proteasome Inhibition ◽  
Synthetic Route ◽  
Tea Leaves ◽  
Green Tea Leaves ◽  
Inhibitory Activities ◽  
Cistus Salvifolius ◽  
Tea Extract

A semi-synthetic route to the D-ring analogs of (–)-epigallocatechin gallate (EGCG) from the relatively abundant (–)-epigallocatechin (EGC), isolated from green tea leaves, is described. A natural product (13), found in Cistus salvifolius, its acetate (14) and analog (17) were synthesized by this method. Their inhibitory activities against proteasomes were investigated.Key words: green tea, (–)-epigallocatechin gallate (EGCG), (–)-epigallocatechin (EGC), proteasome inhibition.

ChemInform Abstract: General Synthetic Route to Anomeric α-Azido and α-Amino Acids and Formal Synthesis of (+)-Hidantocidin (V).

ChemInform ◽  
2010 ◽  
Vol 26 (28) ◽  
pp. no-no
Author(s):  
A. DONDONI ◽  
M.-C. SCHERRMANN ◽  
A. MARRA ◽  
J.-L. DELEPINE
Keyword(s):  
Amino Acids ◽  
Synthetic Route ◽  
Formal Synthesis

scholarly journals Short Enantioselective Formal Synthesis of (–)-Platencin

Synthesis ◽  
2018 ◽  
Vol 50 (22) ◽  
pp. 4359-4368 ◽  
Author(s):  
Brian Stoltz ◽  
Christian Defieber ◽  
Justin Mohr ◽  
Gennadii Grabovyi
Keyword(s):  
Natural Product ◽  
Radical Cyclization ◽  
Formal Synthesis ◽  
Aldol Cyclization ◽  
Key Steps

A short enantioselective formal synthesis of the antibiotic natural product platencin is reported. Key steps in the synthesis include enantioselective decarboxylation alkylation, aldehyde/olefin radical cyclization, and regioselective aldol cyclization.

A Synthetic Route to 11-(1H-Pyrrol-1-yl)-11H-indeno[1,2-b]quinoxaline Derivatives Exploiting a Three-Component Coupling Strategy under Microwave Irradiation.

ChemInform ◽  
2005 ◽  
Vol 36 (51) ◽  
Author(s):  
Javad Azizian ◽  
Ali Reza Karimi ◽  
Zahra Kazemizadeh ◽  
Ali A. Mohammadi ◽  
Mohammad R. Mohammadizadeh
Keyword(s):  
Microwave Irradiation ◽  
Synthetic Route ◽  
Quinoxaline Derivatives ◽  
Coupling Strategy ◽  
Three Component Coupling
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