scholarly journals Catalyst-free and solvent-free Michael addition of 1,3-dicarbonyl compounds to nitroalkenes by a grinding method

2012 ◽  
Vol 8 ◽  
pp. 534-538 ◽  
Author(s):  
Zong-Bo Xie ◽  
Na Wang ◽  
Ming-Yu Wu ◽  
Ting He ◽  
Zhang-Gao Le ◽  
...  
Keyword(s):  
Michael Addition ◽  
Solvent Free ◽  
Environmentally Benign ◽  
Dicarbonyl Compounds ◽  
Catalyst Free ◽  
Grinding Method ◽  
Solvent Free Conditions ◽  
The Michael Addition

An environmentally benign, fast and convenient protocol has been developed for the Michael addition of 1,3-dicarbonyl compounds to β-nitroalkenes in good to excellent yields by a grinding method under catalyst- and solvent-free conditions.

Use of (R)-Mandelic Acid as Chiral Co-Catalyst in the Michael Addition Reaction Organocatalyzed by (1S,4S)-2-Tosyl-2,5-diazabicyclo[2.2.1]heptane under Solvent-Free Conditions

2015 ◽  
Vol 2 (1) ◽  
Author(s):  
C. Gabriela Ávila-Ortiz ◽  
Manuel López-Ortiz ◽  
Alberto Vega-Peñaloza ◽  
Ignacio Regla ◽  
Eusebio Juaristi
Keyword(s):  
Michael Addition ◽  
Mandelic Acid ◽  
Addition Reaction ◽  
Solvent Free ◽  
Reaction Intermediates ◽  
Michael Addition Reaction ◽  
Co Catalyst ◽  
Co Catalysts ◽  
Solvent Free Conditions ◽  
The Michael Addition

AbstractThis article describes a study on the Michael addition reaction of cyclohexanone to nitroolefins catalyzed by the chiral secondary amine (1S,4S)-2-tosyl- 2,5-diazabicyclo[2.2.1]heptane. Reactions were carried out under solvent-free conditions to make them more environmentally friendly. Initially, the observed diastereoand enantioselectivities were moderate to good, but were significantly improved by lowering the reaction temperature. Furthermore, a variety of chiral acids were also tested as co-catalysts in both of their enantiomeric forms, which revealed that (R)-mandelic acid affords excellent results in terms of yield and stereoselectivity. Monitoring the reaction by MS-TOF allowed for the detection of key reaction intermediates, and a reasonable reaction mechanism in which both catalysts are involved is proposed.

scholarly journals Cyanuric Chloride-Catalyzed Michael Addition of Indoles to Nitroolefins under Solvent-Free Conditions

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
Xiao Juan Yang ◽  
Yun Jing
Keyword(s):  
Michael Addition ◽  
Present Method ◽  
Solvent Free ◽  
Cyanuric Chloride ◽  
Reaction Conditions ◽  
Experimental Procedure ◽  
Solvent Free Conditions ◽  
Short Period ◽  
The Michael Addition ◽  
Solvent Free Reaction

Cyanuric chloride is an inexpensive, efficient, and mild catalyst for the Michael addition of indoles to nitroolefins at 70°C under solvent-free conditions. The simple experimental procedure, solvent-free reaction conditions, utilization of an inexpensive and readily available catalyst, short period of conversion, and excellent yields are the advantages of the present method.

Zinc oxide-tetrabutylammonium bromide tandem as a highly efficient, green, and reusable catalyst for the Michael addition of pyrimidine and purine nucleobases to α,β-unsaturated esters under solvent-free conditions

2008 ◽  
Vol 86 (4) ◽  
pp. 317-324 ◽  
Author(s):  
Abdolkarim Zare ◽  
Alireza Hasaninejad ◽  
Mohammad Hassan Beyzavi ◽  
Abolfath Parhami ◽  
Ahmad Reza Moosavi Zare ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Michael Addition ◽  
Tetrabutylammonium Bromide ◽  
Solvent Free ◽  
Reusable Catalyst ◽  
Efficient Procedure ◽  
Unsaturated Esters ◽  
Microwave Assisted ◽  
Solvent Free Conditions ◽  
The Michael Addition

An efficient procedure for the synthesis of carboacyclic nucleosides via microwave-assisted Michael addition of pyrimidine and purine nucleobases to α,β-unsaturated esters in the presence of catalytic amounts of zinc oxide (ZnO) and tetrabutylammonium bromide (TBAB) is described. The reactions proceed rapidly in good to excellent yields.Key words: ZnO–TBAB, green chemistry, Michael addition, nucleobase, solvent-free, microwave.

scholarly journals One-Pot Synthesis of 1,8-Dioxodecahydroacridines and Polyhydroquinoline using 1,3-Di (bromo or chloro)-5,5-Dimethylhydantoin as a Novel and Green Catalyst under Solvent-Free Conditions

2017 ◽  
Vol 57 (4) ◽  
Author(s):  
Behrooz Maleki ◽  
Reza Tayebee ◽  
Mina Kermanian ◽  
Samaneh Sedigh Ashrafi
Keyword(s):  
Ethyl Acetoacetate ◽  
Ammonium Acetate ◽  
Solvent Free ◽  
Environmentally Benign ◽  
One Pot ◽  
Dicarbonyl Compounds ◽  
Green Catalyst ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
Hantzsch Condensation

Solvent-free, one-pot synthesis of polyhdroquinoline and 1,8-dioxodecahydroacridine derivatives have been described via Hantzsch condensation of various aldehydes, ammonium acetate with (<em>i</em>) cyclic 1,3-dicarbonyl compounds and ethyl acetoacetate and (<em>ii</em>) cyclic 1,3-dicarbonyl compounds (2 mmoles) in a very simple, efficient, and environmentally benign method using 1,3-(dibromo or dichloro)-5,5-dimethylhydantoin as a cheap, non-toxic and neutral catalyst with up to excellent yields.

A simple and eco-sustainable method for the sulfonylation of amines under microwave-assisted solvent-free conditions

RSC Advances ◽  
2014 ◽  
Vol 4 (31) ◽  
pp. 16027-16032 ◽  
Author(s):  
Salah Lakrout ◽  
Hacène K'tir ◽  
Aïcha Amira ◽  
Malika Berredjem ◽  
Nour-Eddine Aouf
Keyword(s):  
Microwave Irradiation ◽  
Reaction Times ◽  
Solvent Free ◽  
Environmentally Benign ◽  
Microwave Assisted ◽  
Catalyst Free ◽  
Solvent Free Conditions

A new environmentally benign, simple, and efficient protocol for the sulfonylation of amines using microwave irradiation under solvent- & catalyst-free conditions is reported. The corresponding sulfonamides were obtained in excellent yields within short reaction times.

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