scholarly journals Solvent- and ligand-induced switch of selectivity in gold(I)-catalyzed tandem reactions of 3-propargylindoles

2011 ◽  
Vol 7 ◽  
pp. 786-793 ◽  
Author(s):  
Estela Álvarez ◽  
Delia Miguel ◽  
Patricia García-García ◽  
Manuel A Fernández-Rodríguez ◽  
Félix Rodríguez ◽  
...  
Keyword(s):  
Proper Choice ◽  
Tandem Reaction ◽  
Tandem Reactions ◽  
Nazarov Cyclization ◽  
Reaction Conditions

The selectivity of our previously described gold-catalyzed tandem reaction, 1,2-indole migration followed by aura-iso-Nazarov cyclization, of 3-propargylindoles bearing (hetero)aromatic substituents at both the propargylic and terminal positions, was reversed by the proper choice of the catalyst and the reaction conditions. Thus, 3-(inden-2-yl)indoles, derived from an aura-Nazarov cyclization (instead of an aura-iso-Nazarov cyclization), were obtained in moderate to good yields from a variety of 3-propargylindoles.

Study of the Pyrimidine Nucleobase C5—C6 Bond Reactivity under Thio-Michael/Aldol Tandem Reaction Conditions.

ChemInform ◽  
2007 ◽  
Vol 38 (1) ◽  
Author(s):  
Edna Vazquez Velez ◽  
Celine Desnous ◽  
Pascale Clivio
Keyword(s):  
Tandem Reaction ◽  
Reaction Conditions

Synthesis of 4-arylethyl-6-arylpyrimidine-2-thiols through aza-Michael addition/nucleophilic addition/aromatization tandem reactions

2018 ◽  
Vol 24 (1) ◽  
pp. 23-26
Author(s):  
Zheng Li ◽  
Wenli Song ◽  
Jiaojiao He ◽  
Yan Du ◽  
Jingya Yang
Keyword(s):  
Efficient Method ◽  
Michael Addition ◽  
Nucleophilic Addition ◽  
Tandem Reactions ◽  
Reaction Conditions ◽  
High Yields ◽  
Work Up

Abstract An efficient method for the synthesis of the title compounds by reactions of divinyl ketones with thiourea is described. This protocol has the advantages of high yields, mild reaction conditions and simple work-up procedure.

Diversified Synthesis of 2-(4-Oxo[1,2,3]triazolo[1,5-a]quinoxalin-5(4H)-yl)acetamide Derivatives through Ugi-4-CR and Copper-Catalyzed Tandem Reactions

Synthesis ◽  
2017 ◽  
Vol 49 (17) ◽  
pp. 3863-3873 ◽  
Author(s):  
Yu An ◽  
Huan He ◽  
Tiantian Liu ◽  
Yong Zhang ◽  
Xiaoyun Lu ◽  
...  
Keyword(s):  
Sodium Azide ◽  
Tandem Reaction ◽  
Tandem Reactions ◽  
Rapid Access

A diversified synthesis of 2-(4-oxo[1,2,3]triazolo-[1,5-a]quin­oxalin-5(4H)-yl)acetamide derivatives is demonstrated. The protocol employs a Ugi four-component reaction for the assembling of N-(2-haloaryl)propynamide intermediates and followed by a copper-catalyzed tandem reaction of the synthetic N-(2-haloaryl)propynamides with sodium azide. Such a method provides rapid access to structurally varied and complex fused tricyclic scaffolds through readily available starting materials.

Practical Synthesis of Functionalized Chromeno[3,4-c]pyridine Derivatives via a CuCl2-Catalyzed Tandem Reaction of the Blaise Reaction Intermediates and 3-Cyanocoumarins

Synlett ◽  
2018 ◽  
Vol 29 (07) ◽  
pp. 959-963
Author(s):  
Jian-Jun Li ◽  
Zhiwei Chen ◽  
Yangyang Fan ◽  
Lei Zheng ◽  
Zhaohai Yang
Keyword(s):  
Michael Addition ◽  
Functional Group ◽  
Tandem Reaction ◽  
Pyridine Derivatives ◽  
Reaction Intermediates ◽  
Reaction Conditions ◽  
Purification Technique ◽  
Aromatization Reaction ◽  
Oxidative Aromatization ◽  
Practical Synthesis

This work discloses a novel and efficient protocol for the construction of functionalized chromeno[3,4-c]pyridine derivatives from the Blaise reaction intermediates and 3-cyanocoumarins through a CuCl2-catalyzed sequential Michael addition/intramolecular cyclization/oxidative aromatization reaction. This new method shows the advantages of mild reaction conditions, easy workup, nonchromatographic purification technique, good functional group tolerance, and moderate to good yields.

Construction of 6H-benzo[c]thiochromenes via a tandem reaction of arynes with thionoesters

2021 ◽  
Author(s):  
Yi An ◽  
Fang Zhang ◽  
Guangfen Du ◽  
Zhihua Cai ◽  
Lin He
Keyword(s):  
Transition Metal ◽  
Tandem Reaction ◽  
Tandem Reactions ◽  
Metal Free

A mild and transition-metal free method has been proposed for the synthesis of 6H-benzo[c]thiochromenes via the tandem reactions of arynes with thionoesters.

scholarly journals Efficient synthesis of dihydropyrimidinones via a three-component Biginelli-type reaction of urea, alkylaldehyde and arylaldehyde

2013 ◽  
Vol 9 ◽  
pp. 2846-2851 ◽  
Author(s):  
Haijun Qu ◽  
Xuejian Li ◽  
Fan Mo ◽  
Xufeng Lin
Keyword(s):  
Molecular Iodine ◽  
Tandem Reaction ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
Type Reaction ◽  
Reaction Proceeds ◽  
Phosphoric Acids ◽  
Substituted Urea

A one-pot three-component synthesis of dihydropyrimidinones via a molecular iodine-catalyzed tandem reaction of simple readily available mono-substituted urea, alkylaldehyde, and arylaldehyde has been developed. The reaction proceeds with high chemo- and regioselectivity to give highly diverse dihydropyrimidinones in reasonable yields under mild reaction conditions. Moreover, the first catalytic enantioselective version of this reaction was also realized by using chiral spirocyclic SPINOL-phosphoric acids.

Palladium-catalyzed tandem reaction of 2-hydroxyarylacetonitriles with sodium sulfinates: one-pot synthesis of 2-arylbenzofurans

2014 ◽  
Vol 12 (24) ◽  
pp. 4078-4083 ◽  
Author(s):  
Jiuxi Chen ◽  
Jianjun Li ◽  
Weike Su
Keyword(s):  
Tandem Reaction ◽  
Tandem Reactions ◽  
One Pot ◽  
One Pot Synthesis ◽  
Palladium Catalyzed

Palladium-catalyzed desulfinative addition and intramolecular annulation tandem reactions of 2-hydroxyarylacetonitriles with sodium sulfinates for one-pot synthesis of 2-arylbenzofurans.

Synthesis of naphthalene amino esters and arylnaphthalene lactone lignans through tandem reactions of 2-alkynylbenzonitriles

2014 ◽  
Vol 50 (42) ◽  
pp. 5641-5643 ◽  
Author(s):  
Yan He ◽  
Xinying Zhang ◽  
Xuesen Fan
Keyword(s):  
Tandem Reaction ◽  
Tandem Reactions ◽  
Efficient Synthesis ◽  
Amino Esters

A novel and efficient synthesis of naphthalene amino esters and arylnaphthalene lactone lignans via the tandem reaction of 2-alkynylbenzonitriles is presented.

Palladium(ii)-catalyzed three-component tandem reactions: synthesis of multiply substituted quinolines

2021 ◽  
Author(s):  
Yetong Zhang ◽  
Lepeng Chen ◽  
Yinlin Shao ◽  
Fangjun Zhang ◽  
Zhongyan Chen ◽  
...  
Keyword(s):  
Tandem Reaction ◽  
Tandem Reactions ◽  
Arylboronic Acids ◽  
Substituted Quinolines

The three-component tandem reaction of 2-aminobenzonitriles, arylboronic acids and ketones as available reagents allowing the synthesis of polysubstitution quinolines is reported.

Study of the pyrimidine nucleobase C5C6 bond reactivity under thio-michael/aldol tandem reaction conditions

2006 ◽  
Vol 43 (4) ◽  
pp. 1095-1098 ◽  
Author(s):  
Edna Vázquez Velez ◽  
Céline Desnous ◽  
Pascale Clivio
Keyword(s):  
Tandem Reaction ◽  
Reaction Conditions
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