scholarly journals Scalable synthesis of (1-cyclopropyl)cyclopropylamine hydrochloride

2011 ◽  
Vol 7 ◽  
pp. 1003-1006 ◽  
Author(s):  
Sergei I Kozhushkov ◽  
Alexander F Khlebnikov ◽  
Rafael R Kostikov ◽  
Dmitrii S Yufit ◽  
Armin de Meijere
Keyword(s):  
Hydrogen Chloride ◽  
Diethyl Ether ◽  
Large Scale ◽  
Scalable Synthesis ◽  
Curtius Degradation

1-Cyclopropylcyclopropanecarboxylic acid (2), which is accessible on a large scale (900 mmol) from 1-bromo-1-cyclopropylcyclopropane (1) in 64% yield (89% on a 12.4 mmol scale), has been subjected to a Curtius degradation employing the Weinstock protocol to furnish the N-Boc-protected (1-cyclopropyl)cyclopropylamine 3 (76%). Deprotection of 3 with hydrogen chloride in diethyl ether gave the (1-cyclopropyl)cyclopropylamine hydrochloride (4·HCl) in 87% yield.

Towards scalable synthesis of high-quality PbS colloidal quantum dots for photovoltaic applications

2019 ◽  
Vol 7 (6) ◽  
pp. 1575-1583 ◽  
Author(s):  
Sijie Zhou ◽  
Zeke Liu ◽  
Yongjie Wang ◽  
Kunyuan Lu ◽  
Fan Yang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Large Scale ◽  
Colloidal Quantum Dots ◽  
High Yield ◽  
High Quality ◽  
Excellent Quality ◽  
Photovoltaic Applications ◽  
Photovoltaic Technology ◽  
Scalable Synthesis ◽  
Large Scale Manufacture

Accelerating inorganic nanocrystal-based photovoltaic technology needs more efficient synthetic protocols for large scale manufacture, high yield and excellent quality nanocrystal materials.

A Scalable Synthesis of Biaryl Unit of the HIV Protease Inhibitor Atazanavir

2019 ◽  
Vol 17 (1) ◽  
pp. 68-72
Author(s):  
Chapala Vijayalakshmi ◽  
Malavattu G. Prasad ◽  
Naresh K. Katari ◽  
Pedavenkatagari N. Reddy
Keyword(s):  
Protease Inhibitor ◽  
Large Scale ◽  
Cyano Group ◽  
Cost Effective ◽  
Pharmacokinetic Profile ◽  
Hiv Protease ◽  
Tert Butyl ◽  
Palladium Catalyzed ◽  
Scalable Synthesis

Atazanavir is one of the most prescribed HIV-1 protease inhibitors approved by the FDA. It was the first protease inhibitor approved for once-a-day dosing to treat AIDS due to good oral bioavailability and favorable pharmacokinetic profile. This research aims to develop a new synthetic cost effective process for biaryl-hydrazine unit {tert-butyl 2-[4-(2-pyridinyl)benzyl]hydrazinecarboxylate} of atazanavir on a large scale. The synthesis involved palladium catalyzed Suzuki-Miyaura coupling of 2-chloropyridine and (4-cyanophenyl)boronic acid followed by DIBAL-H reduction of cyano group to aldehyde which is then treated with tert-butyl carbazate to furnish hydrazone subsequently in situ reduction with NaBH4. A large scale synthesis of biaryl-hydrazine unit of atazanavir was accomplished in three steps with 71% overall yield. We have developed a short and efficient synthesis of atazanavir key intermediate biaryl-hydrazine unit. The process does not require the usage of Grignard reagent, expensive catalyst, protection/deprotection of aldehyde moiety and catalytic hydrogenation.

scholarly journals Scalable Synthesis of 1,3,4,5-Tetraaryl Imidazolium Salts as Precursors of Sterically Demanding N-Heterocyclic Carbenes

SynOpen ◽  
2020 ◽  
Vol 04 (01) ◽  
pp. 01-11
Author(s):  
Cengiz Azap ◽  
Anna Christoffers ◽  
Renat Kadyrov
Keyword(s):  
Large Scale ◽  
Oxidative Desulfurization ◽  
Heterocyclic Carbenes ◽  
Imidazolium Salts ◽  
Imidazolium Salt ◽  
Available N ◽  
Sterically Demanding ◽  
Cost Efficient ◽  
Scalable Synthesis ◽  
Electron Donation

A convenient, large-scale, and cost-efficient synthesis of 4,5-diarylsubstituted N,N-diarylimidazolium salts is described. A variety of 1,3,4,5-tetraaryl imidazolium salts with increasing electron donation and steric bulk of the N-aryl groups was synthesized in good yields. In the key step, readily available N,N′-diarylthioureas and benzoin/anisoin are coupled to give imidazole-2-thiones, followed by imidazolium salt formation by oxidative desulfurization. In this way, N,N-diarylimidazolium salts with 2-methoxy, 2-methyl, and 2-isopropyl substituents could be obtained; the synthesis of their 2-tert-butyl, 2,6-dimethyl, and 2,6-diisopropyl analogues failed.

Scalable synthesis of SnS2/S-doped graphene composites for superior Li/Na-ion batteries

Nanoscale ◽  
2017 ◽  
Vol 9 (39) ◽  
pp. 14820-14825 ◽  
Author(s):  
Penglun Zheng ◽  
Zhengfei Dai ◽  
Yu Zhang ◽  
Khang Ngoc Dinh ◽  
Yun Zheng ◽  
...  
Keyword(s):  
Large Scale ◽  
Regeneration Strategy ◽  
Doped Graphene ◽  
Scalable Synthesis

A facile dissolution–regeneration strategy is proposed to construct large-scale flexible SnS2/sulfur-doped graphene composites as anodes for LIBs and SIBs.

scholarly journals Synthesis of DNA Origami Scaffolds: Current and Emerging Strategies

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3386 ◽  
Author(s):  
Joshua Bush ◽  
Shrishti Singh ◽  
Merlyn Vargas ◽  
Esra Oktay ◽  
Chih-Hsiang Hu ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Large Scale ◽  
Structural Complexity ◽  
Dna Origami ◽  
Single Stranded Dna ◽  
Promising Tool ◽  
Design Flexibility ◽  
Scalable Synthesis ◽  
Scalable Methods ◽  
Dna Scaffold

DNA origami nanocarriers have emerged as a promising tool for many biomedical applications, such as biosensing, targeted drug delivery, and cancer immunotherapy. These highly programmable nanoarchitectures are assembled into any shape or size with nanoscale precision by folding a single-stranded DNA scaffold with short complementary oligonucleotides. The standard scaffold strand used to fold DNA origami nanocarriers is usually the M13mp18 bacteriophage’s circular single-stranded DNA genome with limited design flexibility in terms of the sequence and size of the final objects. However, with the recent progress in automated DNA origami design—allowing for increasing structural complexity—and the growing number of applications, the need for scalable methods to produce custom scaffolds has become crucial to overcome the limitations of traditional methods for scaffold production. Improved scaffold synthesis strategies will help to broaden the use of DNA origami for more biomedical applications. To this end, several techniques have been developed in recent years for the scalable synthesis of single stranded DNA scaffolds with custom lengths and sequences. This review focuses on these methods and the progress that has been made to address the challenges confronting custom scaffold production for large-scale DNA origami assembly.

Scalable synthesis of high-quality transition metal dichalcogenide nanosheets and their application as sodium-ion battery anodes

2016 ◽  
Vol 4 (44) ◽  
pp. 17370-17380 ◽  
Author(s):  
Jingwen Zhou ◽  
Jian Qin ◽  
Lichao Guo ◽  
Naiqin Zhao ◽  
Chunsheng Shi ◽  
...  
Keyword(s):  
Transition Metal ◽  
Crystalline Structure ◽  
Large Scale ◽  
Sodium Ion ◽  
Sodium Ion Battery ◽  
Transition Metal Dichalcogenide ◽  
High Quality ◽  
Single Crystalline ◽  
Scalable Synthesis

High-quality 2D WS2, MoS2, MoSe2 and WSe2 nanosheets with a single-crystalline structure have been synthesized on a large scale by a NaCl template-assisted strategy.

How do nitrogen-doped carbon dots generate from molecular precursors? An investigation of the formation mechanism and a solution-based large-scale synthesis

2015 ◽  
Vol 3 (27) ◽  
pp. 5608-5614 ◽  
Author(s):  
Yaoping Hu ◽  
Jing Yang ◽  
Jiangwei Tian ◽  
Jun-Sheng Yu
Keyword(s):  
Formation Mechanism ◽  
Formation Process ◽  
Carbon Dots ◽  
Large Scale ◽  
Molecular Precursors ◽  
Nitrogen Doped ◽  
Scalable Synthesis ◽  
Doped Carbon Dots ◽  
Nitrogen Doped Carbon ◽  
Fluorescent Carbon Dots

A solution-based method is developed for rapid and scalable synthesis of highly fluorescent carbon dots in a monoethanolamine system, and an interesting formation process of carbon dots is directly observed.

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