scholarly journals Gold film-catalysed benzannulation by Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS)

2009 ◽  
Vol 5 ◽  
Author(s):  
Gjergji Shore ◽  
Michael Tsimerman ◽  
Michael G Organ
Keyword(s):  
Microwave Irradiation ◽  
Functional Groups ◽  
Organic Synthesis ◽  
Continuous Flow ◽  
Metal Film ◽  
Silver Film ◽  
Gold Film ◽  
Microwave Assisted ◽  
Glass Capillaries ◽  
Inner Surface

Methodology has been developed for laying down a thin gold-on-silver film on the inner surface of glass capillaries for the purpose of catalysing benzannulation reactions. The cycloaddition precursors are flowed through these capillaries while the metal film is being heated to high temperatures using microwave irradiation. The transformation can be optimized rapidly, tolerates a wide number of functional groups, is highly regioselective, and proceeds in good to excellent conversion.

scholarly journals Cycloaddition of Thiourea- and Guanidine-Substituted Furans to Dienophiles: A Comparison of the Environmentally-Friendly Methods

2020 ◽  
Vol 3 (1) ◽  
pp. 57
Author(s):  
Luka Barešić ◽  
Davor Margetić ◽  
Zoran Glasovac
Keyword(s):  
High Pressure ◽  
Functional Groups ◽  
Organic Synthesis ◽  
High Speed ◽  
Environmentally Friendly ◽  
Microwave Assisted ◽  
Pressure Synthesis ◽  
Ultrasound Assisted ◽  
Substituted Furans ◽  
Guanidine Moiety

The cycloaddition strategy was employed in order to obtain a 7-oxanorbornene framework substituted with a guanidine moiety or its precursor functional groups: protected amine or thiourea. In order to optimize the conditions for the cycloaddition, several environmentally-friendly methods—microwave assisted organic synthesis, high pressure synthesis, high speed vibrational milling, and ultrasound assisted synthesis—were employed. The outcomes of the cycloaddition reactions were interpreted in terms of endo/exo selectivity, the conversion of the reactants to the product, and the isolated yields. In general, our results indicated the HP and HSVM approaches as the methods of choice to give good yields and conversions.

scholarly journals Synthesis of an Isoindoline-Annulated, Tricyclic Sultam Library via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS)

Synthesis ◽  
2012 ◽  
Vol 44 (16) ◽  
pp. 2547-2554 ◽  
Author(s):  
Paul Hanson ◽  
Michael Organ ◽  
Farman Ullah ◽  
Qin Zang ◽  
Salim Javed ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Continuous Flow ◽  
Microwave Assisted

Microwave-assisted Carbon-carbon and Carbon-heteroatom Cross-coupling Reactions in Organic Synthesis

2020 ◽  
Vol 7 (2) ◽  
pp. 86-98
Author(s):  
Rammyani Pal ◽  
Chhanda Mukhopadhyay
Keyword(s):  
Microwave Irradiation ◽  
Organic Synthesis ◽  
Cross Coupling ◽  
Side Reactions ◽  
Coupling Reactions ◽  
Considerable Effort ◽  
Microwave Assisted ◽  
External Heat Source ◽  
Cross Coupling Reactions ◽  
Metal Catalyzed

Conventionally, the organic reactions are accomplished by conductive heating with an external heat source like an oil bath. On the contrary, since its inception, the application of microwave irradiation is growing as a suitable alternate heating method in organic synthesis. Microwave heating considerably reduces the reaction time without promoting any side reactions. The fundamental synthetic organic chemistry majorly deals with transition-metal-catalyzed C–C and C–heteroatom bond formation reactions. It is one of the most important methods in contemporary chemistry resulting in a tremendous increment in the applications of these reactions during the last few years. This field has been acknowledged with a number of Nobel Prizes during the last decade (2001, 2005 and 2010). A considerable effort has been done on the continuous development of new ligands and catalysts as well as an increased understanding of the mechanisms for the improvement of the reaction condition. This review focuses on some of the latest developments in the area of cross-coupling reactions aided by microwave irradiation.

ChemInform Abstract: Synthesis of an Isoindoline-Annulated, Tricyclic Sultam Library via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS).

ChemInform ◽  
2012 ◽  
Vol 43 (47) ◽  
pp. no-no
Author(s):  
Farman Ullah ◽  
Qin Zang ◽  
Salim Javed ◽  
Patrick Porubsky ◽  
Benjamin Neuenswander ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Continuous Flow ◽  
Microwave Assisted

scholarly journals Accessing Stereochemically Rich Sultams via Microwave-assisted, Continuous-flow Organic Synthesis (MACOS) Scale-out

2012 ◽  
Vol 1 (1) ◽  
pp. 32-39 ◽  
Author(s):  
Michael G. Organ ◽  
Paul R. Hanson ◽  
Alan Rolfe ◽  
Thiwanka B. Samarakoon ◽  
Farman Ullah
Keyword(s):  
Organic Synthesis ◽  
Continuous Flow ◽  
Microwave Assisted
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