scholarly journals A chromatography-free and aqueous waste-free process for thioamide preparation with Lawesson’s reagent

2021 ◽  
Vol 17 ◽  
pp. 805-812
Author(s):  
Ke Wu ◽  
Yichen Ling ◽  
An Ding ◽  
Liqun Jin ◽  
Nan Sun ◽  
...  
Keyword(s):  
Large Scale ◽  
Scaling Up ◽  
Small Scale ◽  
Substitution Reactions ◽  
Great Opportunity ◽  
Lawesson’S Reagent ◽  
Free Process ◽  
Aqueous Waste ◽  
Scale Preparation ◽  
Lawesson's Reagent

After completing the thio-substitution with Lawesson’s reagent, ethanol was found to be effective in the decomposition of the inherent stoichiometric six-membered-ring byproduct from the Lawesson’s reagent to a highly polarized diethyl thiophosphonate. The treatment significantly simplified the following chromatography purification of the desired thioamide in a small scale preparation. As scaling up the preparation of two pincer-type thioamides, we have successfully developed a convenient process with ethylene glycol to replace ethanol during the workup, including a traditional phase separation, extraction, and recrystallization. The newly developed chromatography-free procedure did not generate P-containing aqueous waste, and only organic effluents were discharged. It is believed that the optimized procedure offers the great opportunity of applying the Lawesson’s reagent for various thio-substitution reactions on a large scale.

scholarly journals A Column-Free and Aqueous Waste-Free Process for Thioamide Preparation with Lawesson’s reagent

2020 ◽  
Author(s):  
Ke Wu ◽  
Yichen Ling ◽  
An Ding ◽  
Liqun Jin ◽  
Nan Sun ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Scaling Up ◽  
Membered Ring ◽  
Small Scale ◽  
Lawesson’S Reagent ◽  
Free Process ◽  
Aqueous Waste ◽  
Scale Preparation ◽  
Lawesson's Reagent

After completing thio-substitution with the Lawesson’s reagent, ethanol was found to be able to efficiently decompose the inherent stoichiometric six-membered-ring by-product from the Lawesson’s reagent to a highly polarized diethyl thiophosphate. This treatment could significantly simplify the following column purification of the desired thioamide in a small scale preparation. As scaling up the preparation of two pincer-type thioamides, we have successfully developed a convenient process with ethylene glycol to replace ethanol during the workup, including traditional phase-cut, extraction, and re-crystallization. The newly developed column-free procedure did not generate P-contained aqueous waste, and only organic effluents were discharged. It was believed that the optimized procedure can greatly provide opportunity of the application of the Lawesson’s reagent for various thio-substituted reacions in scaling up preparation.

scholarly journals Biohybrid Actuators for Soft Robotics: Challenges in Scaling Up

Actuators ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 96
Author(s):  
Phillip Won ◽  
Seung Hwan Ko ◽  
Carmel Majidi ◽  
Adam W. Feinberg ◽  
Victoria A. Webster-Wood
Keyword(s):  
Large Scale ◽  
Scaling Up ◽  
Living Cells ◽  
Living Systems ◽  
Soft Robotics ◽  
Small Scale ◽  
Self Healing ◽  
Artificial Structures ◽  
Wide Range ◽  
Macro Scale

Living systems have evolved to survive in a wide range of environments and safely interact with other objects and organisms. Thus, living systems have been the source of inspiration for many researchers looking to apply their mechanics and unique characteristics in engineering robotics. Moving beyond bioinspiration, biohybrid actuators, with compliance and self-healing capabilities enabled by living cells or tissue interfaced with artificial structures, have drawn great interest as ways to address challenges in soft robotics, and in particular have seen success in small-scale robotic actuation. However, macro-scale biohybrid actuators beyond the centimeter scale currently face many practical obstacles. In this perspective, we discuss the challenges in scaling up biohybrid actuators and the path to realize large-scale biohybrid soft robotics.

scholarly journals A Fast Multiscale Clustering Approach Based on DBSCAN

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Runzi Chen ◽  
Shuliang Zhao ◽  
Meishe Liang
Keyword(s):  
Large Scale ◽  
Computational Cost ◽  
Scaling Up ◽  
Practical Significance ◽  
Small Scale ◽  
Large Scale Data ◽  
Traditional Algorithm ◽  
Multiscale Clustering ◽  
Clustering Approach ◽  
Scale Data

Multiscale brings great benefits for people to observe objects or problems from different perspectives. It has practical significance for clustering on multiscale data. At present, there is a lack of research on the clustering of large-scale data under the premise that clustering results of small-scale datasets have been obtained. If one does cluster on large-scale datasets by using traditional methods, two disadvantages are as follows: (1) Clustering results of small-scale datasets are not utilized. (2) Traditional method will cause more running overhead. Aims at these shortcomings, this paper proposes a multiscale clustering framework based on DBSCAN. This framework uses DBSCAN for clustering small-scale datasets, then introduces algorithm Scaling-Up Cluster Centers (SUCC) generating cluster centers of large-scale datasets by merging clustering results of small-scale datasets, not mining raw large-scale datasets. We show experimentally that, compared to traditional algorithm DBACAN and leading algorithms DBSCAN++ and HDBSCAN, SUCC can provide not only competitive performance but reduce computational cost. In addition, under the guidance of experts, the performance of SUCC is more competitive in accuracy.

Large-scale questions and small-scale data: empirical and theoretical methods for scaling up in ecology

Oecologia ◽  
2005 ◽  
Vol 145 (2) ◽  
pp. 176-177 ◽  
Author(s):  
N. Underwood ◽  
P. Hambäck ◽  
B. D. Inouye
Keyword(s):  
Large Scale ◽  
Scaling Up ◽  
Small Scale ◽  
Theoretical Methods ◽  
Scale Data

Small-Scale Science to Large-Scale Profession

2000 ◽  
Vol 45 (4) ◽  
pp. 396-398
Author(s):  
Roger Smith
Keyword(s):  
Large Scale ◽  
Small Scale

Purification of the Antihemophilic Factor by Gel Filtration on Agarose

1969 ◽  
Vol 22 (03) ◽  
pp. 577-583 ◽  
Author(s):  
M.M.P Paulssen ◽  
A.C.M.G.B Wouterlood ◽  
H.L.M.A Scheffers
Keyword(s):  
Factor Viii ◽  
Plasma Proteins ◽  
Large Scale ◽  
Gel Filtration ◽  
Large Scale Preparation ◽  
Scale Preparation ◽  
Antihemophilic Factor

SummaryFactor VIII can be isolated from plasma proteins, including fibrinogen by chromatography on agarose. The best results were obtained with Sepharose 6B. Large scale preparation is also possible when cryoprecipitate is separated by chromatography. In most fractions containing factor VIII a turbidity is observed which may be due to the presence of chylomicrons.The purified factor VIII was active in vivo as well as in vitro.

Development of Physics Learning Module Based on Guided Inquiry with Light Wave Material in Class XI of Senior High School

2020 ◽  
Vol 1 (1) ◽  
pp. 1-10
Author(s):  
Evi Rahmawati ◽  
Irnin Agustina Dwi Astuti ◽  
N Nurhayati
Keyword(s):  
Large Scale ◽  
Learning Strategy ◽  
Student Response ◽  
Average Score ◽  
Small Scale ◽  
Design Development ◽  
Teacher Response ◽  
Student Responses ◽  
Analysis Design ◽  
Scientific Skills

IPA Integrated is a place for students to study themselves and the surrounding environment applied in daily life. Integrated IPA Learning provides a direct experience to students through the use and development of scientific skills and attitudes. The importance of integrated IPA requires to pack learning well, integrated IPA integration with the preparation of modules combined with learning strategy can maximize the learning process in school. In SMP 209 Jakarta, the value of the integrated IPA is obtained from 34 students there are 10 students completed and 24 students are not complete because they get the value below the KKM of 68. This research is a development study with the development model of ADDIE (Analysis, Design, Development, Implementation, and Evaluation). The use of KPS-based integrated IPA modules (Science Process sSkills) on the theme of rainbow phenomenon obtained by media expert validation results with an average score of 84.38%, average material expert 82.18%, average linguist 75.37%. So the average of all aspects obtained by 80.55% is worth using and tested to students. The results of the teacher response obtained 88.69% value with excellent criteria. Student responses on a small scale acquired an average score of 85.19% with highly agreed criteria and on the large-scale student response gained a yield of 86.44% with very agreed criteria. So the module can be concluded receiving a good response by the teacher and students.

Planetary gentrification and urban (re)development

2019 ◽  
Vol 61 (1) ◽  
pp. 5-13 ◽  
Author(s):  
Loretta Lees
Keyword(s):  
Low Income ◽  
Policy Making ◽  
Large Scale ◽  
Urban Redevelopment ◽  
Urban Transformation ◽  
Small Scale ◽  
Income Groups ◽  
Low Income Groups

Abstract Gentrification is no-longer, if it ever was, a small scale process of urban transformation. Gentrification globally is more often practised as large scale urban redevelopment. It is state-led or state-induced. The results are clear – the displacement and disenfranchisement of low income groups in favour of wealthier in-movers. So, why has gentrification come to dominate policy making worldwide and what can be done about it?

AGRICULTURAL PRODUCTION OF CA DONG PEOPLE IN RESETTLEMENT AREA OF TRANH RIVER HYDROPOWER NUMBER 2: CURRENT SITUATION AND IMPACT FACTORS

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Bùi Thị Bích Lan
Keyword(s):  
Social Relations ◽  
Agricultural Production ◽  
Large Scale ◽  
Transition Process ◽  
Impact Factors ◽  
Small Scale ◽  
Scale Production ◽  
Technical Application ◽  
Production Models ◽  
Role Of The State

In Vietnam, the construction of hydropower projects has contributed significantly in the cause of industrialization and modernization of the country. The place where hydropower projects are built is mostly inhabited by ethnic minorities - communities that rely primarily on land, a very important source of livelihood security. In the context of the lack of common productive land in resettlement areas, the orientation for agricultural production is to promote indigenous knowledge combined with increasing scientific and technical application; shifting from small-scale production practices to large-scale commodity production. However, the research results of this article show that many obstacles in the transition process are being posed such as limitations on natural resources, traditional production thinking or the suitability and effectiveness of scientific - technical application models. When agricultural production does not ensure food security, a number of implications for people’s lives are increasingly evident, such as poverty, preserving cultural identity, social relations and resource protection. Since then, it has set the role of the State in researching and building appropriate agricultural production models to exploit local strengths and ensure sustainability.

Managing the impacts of mining on Ghana’s water resources from a legal perspective

2018 ◽  
Vol 1 (3) ◽  
pp. 156-165 ◽  
Author(s):  
Nasirudeen Abdul Fatawu
Keyword(s):  
Surface Water ◽  
Water Resources ◽  
Environmental Protection Agency ◽  
Large Scale ◽  
Small Scale ◽  
Mining Activities ◽  
Protection Agency ◽  
Environmental Laws ◽  
Mining Areas ◽  
Legal Perspective

Recent floods in Ghana are largely blamed on mining activities. Not only are lives lost through these floods, farms andproperties are destroyed as a result. Water resources are diverted, polluted and impounded upon by both large-scale minersand small-scale miners. Although these activities are largely blamed on behavioural attitudes that need to be changed, thereare legal dimensions that should be addressed as well. Coincidentally, a great proportion of the water resources of Ghana arewithin these mining areas thus the continual pollution of these surface water sources is a serious threat to the environmentand the development of the country as a whole. The environmental laws need to be oriented properly with adequate sanctionsto tackle the impacts mining has on water resources. The Environmental Impact Assessment (EIA) procedure needs to bestreamlined and undertaken by the Environmental Protection Agency (EPA) and not the company itself.

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