scholarly journals Designed whole-cell-catalysis-assisted synthesis of 9,11-secosterols

2021 ◽  
Vol 17 ◽  
pp. 581-588
Author(s):  
Marek Kõllo ◽  
Marje Kasari ◽  
Villu Kasari ◽  
Tõnis Pehk ◽  
Ivar Järving ◽  
...  
Keyword(s):  
Synthetic Biology ◽  
Step Method ◽  
Reaction Conditions ◽  
Whole Cell ◽  
Chemical Cleavage ◽  
Whole Cell Biocatalysis ◽  
Vicinal Diol ◽  
Regioselective Hydroxylation ◽  
Whole Cell Catalysis ◽  
Key Steps

A method for the synthesis of 9,11-secosteroids starting from the natural corticosteroid cortisol is described. There are two key steps in this approach, combining chemistry and synthetic biology. Stereo- and regioselective hydroxylation at C9 (steroid numbering) is carried out using whole-cell biocatalysis, followed by the chemical cleavage of the C–C bond of the vicinal diol. The two-step method features mild reaction conditions and completely excludes the use of toxic oxidants.

scholarly journals Applications of the Horner-Wadsworth-Emmons olefination in modern natural product synthesis

Synthesis ◽  
2021 ◽  
Author(s):  
Dávid Roman ◽  
Maria Sauer ◽  
Christine Beemelmanns
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Natural Product Synthesis ◽  
Reaction Conditions ◽  
Comprehensive Review ◽  
Modern Natural ◽  
Key Steps ◽  
Synthetic Approaches

Here, we have summarized more than 30 representative natural product syntheses published in 2015 to 2020 that employ one or more Horner-Wadsworth-Emmons (HWE) reactions. We comprehensively describe the applied phosphonate reagents, HWE reaction conditions and key steps of the total synthetic approaches. Our comprehensive review will support future synthetic approaches and serve as guideline to find the best HWE conditions for the most complicated natural products known

scholarly journals In Vivo Assembly of Artificial Metalloenzymes and Application in Whole‐Cell Biocatalysis**

2021 ◽  
Author(s):  
Shreyans Chordia ◽  
Siddarth Narasimhan ◽  
Alessandra Lucini Paioni ◽  
Marc Baldus ◽  
Gerard Roelfes
Keyword(s):  
Whole Cell ◽  
Whole Cell Biocatalysis ◽  
Artificial Metalloenzymes

Enantiocomplementary decarboxylative hydroxylation combining photocatalysis and whole-cell biocatalysis in a one-pot cascade process

2019 ◽  
Vol 21 (8) ◽  
pp. 1907-1911 ◽  
Author(s):  
Jian Xu ◽  
Mamatjan Arkin ◽  
Yongzhen Peng ◽  
Weihua Xu ◽  
Huilei Yu ◽  
...  
Keyword(s):  
Cascade Process ◽  
One Pot ◽  
Whole Cell ◽  
Whole Cell Biocatalysis

The first demonstration of photochemo-enzymatic whole-cell one-pot enantiocomplementary decarboxylative hydroxylation.

Whole‐cell biocatalysis: Advancements toward the biosynthesis of fuels

2021 ◽  
Author(s):  
Tanushree Baldeo Madavi ◽  
Sushma Chauhan ◽  
Anushri Keshri ◽  
Hemasundar Alavilli ◽  
Kwon‐Young Choi ◽  
...  
Keyword(s):  
Whole Cell ◽  
Whole Cell Biocatalysis

GM3 trisaccharide biosynthesis and process optimization using engineered E. coli lysate and whole-cell catalysis

2020 ◽  
Vol 39 (5-6) ◽  
pp. 217-231
Author(s):  
Lipeng Feng ◽  
Jie Shi ◽  
Haofei Hong ◽  
Zhifang Zhou ◽  
Zhimeng Wu
Keyword(s):  
Process Optimization ◽  
Whole Cell ◽  
E Coli ◽  
Whole Cell Catalysis
Sign in / Sign up

Export Citation Format

Share Document