scholarly journals 1,2,3-Triazoles as leaving groups: SNAr reactions of 2,6-bistriazolylpurines with O- and C-nucleophiles

2021 ◽  
Vol 17 ◽  
pp. 410-419
Author(s):  
Dace Cīrule ◽  
Irina Novosjolova ◽  
Ērika Bizdēna ◽  
Māris Turks
Keyword(s):  
New Approach ◽  
Bond Forming ◽  
Mild Conditions ◽  
Leaving Group ◽  
Bond Forming Reactions ◽  
Leaving Groups

A new approach was designed for the synthesis of C6-substituted 2-triazolylpurine derivatives. A series of substituted products was obtained in SNAr reactions between 2,6-bistriazolylpurine derivatives and O- and C-nucleophiles under mild conditions. The products were isolated in yields up to 87%. The developed C–O and C–C bond forming reactions clearly show the ability of the 1,2,3-triazolyl ring at the C6 position of purine to act as leaving group.

A ruthenium-catalyzed alkenylation–annulation approach for the synthesis of indazole derivatives via C–H bond activation

2018 ◽  
Vol 16 (33) ◽  
pp. 5973-5978 ◽  
Author(s):  
Maral Gholamhosseyni ◽  
Ebrahim Kianmehr
Keyword(s):  
Bond Activation ◽  
New Approach ◽  
Bond Forming ◽  
Bond Forming Reactions

A new approach to indazole derivatives through a Ru(ii)-catalyzed C–H activation–annulation reaction, which proceeds via C–C and C–N bond forming reactions, is reported.

scholarly journals Microporous polyurethane material for size selective heterogeneous catalysis of the Knoevenagel reaction

2016 ◽  
Vol 52 (50) ◽  
pp. 7834-7837 ◽  
Author(s):  
Sandeep Kumar Dey ◽  
Nader de Sousa Amadeu ◽  
Christoph Janiak
Keyword(s):  
Heterogeneous Catalysis ◽  
Knoevenagel Reaction ◽  
Bond Forming ◽  
Mild Conditions ◽  
Bond Forming Reactions ◽  
Type C ◽  
High Yields ◽  
First Time

For the first time, a microporous polyurethane (MPU) is prepared – it acts as an organocatalyst for aldol-type C–C bond forming reactions with high yields and under mild conditions.

Synthesis of (±)-aphanorphine: a new approach to tricyclic 3-benzazepine scaffold using two radical C–C bond-forming reactions

2008 ◽  
Vol 49 (29-30) ◽  
pp. 4473-4475 ◽  
Author(s):  
Takehiko Yoshimitsu ◽  
Chie Atsumi ◽  
Emiko Iimori ◽  
Hiroto Nagaoka ◽  
Tetsuaki Tanaka
Keyword(s):  
New Approach ◽  
Bond Forming ◽  
Bond Forming Reactions

Recent advances in asymmetric organocatalysis mediated by bifunctional amine–thioureas bearing multiple hydrogen-bonding donors

2015 ◽  
Vol 51 (7) ◽  
pp. 1185-1197 ◽  
Author(s):  
Xin Fang ◽  
Chun-Jiang Wang
Keyword(s):  
Hydrogen Bonding ◽  
Recent Progress ◽  
Bond Forming ◽  
Mild Conditions ◽  
Recent Advances ◽  
Bond Forming Reactions ◽  
Asymmetric Organocatalysis ◽  
Multiple Hydrogen Bonding

Recent progress in asymmetric organocatalysis, focusing on fine-tunable amine–thiourea catalysis, is described. Design of novel bifunctional amine–thiourea organocatalysts bearing multiple hydrogen-bonding donors and their applications in asymmetric C–C, C–N, and C–S bond-forming reactions under mild conditions are discussed.

Recent Advances on C-Se Bond-forming Reactions at Low and Room Temperature

2020 ◽  
Vol 23 (28) ◽  
pp. 3206-3225 ◽  
Author(s):  
Amol D. Sonawane ◽  
Mamoru Koketsu
Keyword(s):  
Room Temperature ◽  
Bond Formation ◽  
Bond Forming ◽  
Material Chemistry ◽  
Recent Advances ◽  
Bond Forming Reactions ◽  
Bond Formation Reactions

: Over the last decades, many methods have been reported for the synthesis of selenium- heterocyclic scaffolds because of their interesting reactivities and applications in the medicinal as well as in the material chemistry. This review describes the recent numerous useful methodologies on C-Se bond formation reactions which were basically carried out at low and room temperature.

Graphene Oxide and Its Derivatives: Their Synthesis and Use in Organic Synthesis

2019 ◽  
Vol 23 (2) ◽  
pp. 188-204 ◽  
Author(s):  
Xiangjun Peng ◽  
Xianyun Xu ◽  
Fujiang Huang ◽  
Qian Liu ◽  
Liangxian Liu
Keyword(s):  
Graphene Oxide ◽  
Carbon Materials ◽  
Device Fabrication ◽  
Organic Reactions ◽  
Bond Forming ◽  
Bond Forming Reactions ◽  
Modern Physics ◽  
Recent Developments ◽  
Optical And Mechanical Properties ◽  
Nitrogen Double Bond

Since Geim and co-workers reported their groundbreaking experiments on graphene, research on graphene oxide (GO) and its derivatives has greatly influenced the field of modern physics, chemistry, device fabrication, material science, and nanotechnology. The unique structure and fascinating properties of these carbon materials can be ascribed to their eminent chemical, electronic, electrochemical, optical, and mechanical properties of GO and its derivatives, particularly compared to other carbon allotropes. The present Review aims to provide an overview on the recent developments in the preparation of GO and its derivatives and their applications in organic reactions. We will first outline the synthesis of GO and its derivatives. Then, we will discuss the major sections about their application as stoichiometric and catalytic oxidants in organic reactions, a particular emphasis on the carbon-carbon, carbon-oxygen, and carbon-nitrogen single bond-forming reactions, as well as carbon-oxygen and carbon-nitrogen double bond-forming reactions. Simultaneously, this Review also describes briefly transition metal supported on GO or its derivatives as a catalyst for organic reaction. Lastly, we will present an outlook of potential areas where GO and its derivatives may be expected to find utility or opportunity for further growth and study.

The effect of steric size of leaving group on rates of the competing syn- and anti-pathways in biomolecular elimination

1980 ◽  
Vol 45 (8) ◽  
pp. 2171-2178
Author(s):  
Jiří Závada ◽  
Magdalena Pánková
Keyword(s):  
Comparative Analysis ◽  
Homologous Series ◽  
Leaving Group ◽  
Leaving Groups

Approximate rates of the competing syn- and anti-pathways have been determined in t-C4H9OK-t-C4H9OH promoted elimination from two homologous series of tosylates: I-OTs trans-III (R = H, CH3, C2H5, n-C3H7, i-C3H7, t-C4H9) and II-OTs trans-IV (R = CH3, C2H5, n-C3H7, i-C3H7, t-C4H9). A comparison has been made with rates of the same processes in the (+) elimination of the corresponding trimethylammonium salts I-N(CH3)3 trans-III and (+) II-N(CH3)3 trans-IV. The title effect is demonstrated by a comparative analysis of the rate patterns obtained for the two leaving groups.

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