scholarly journals Synergistic approach to polycycles through Suzuki–Miyaura cross coupling and metathesis as key steps

2018 ◽  
Vol 14 ◽  
pp. 2468-2481 ◽  
Author(s):  
Sambasivarao Kotha ◽  
Milind Meshram ◽  
Chandravathi Chakkapalli
Keyword(s):  
Recent Work ◽  
Claisen Rearrangement ◽  
Cross Coupling ◽  
Alder Reaction ◽  
Diels Alder ◽  
Enyne Metathesis ◽  
Cross Metathesis ◽  
Diels Alder Reaction ◽  
Synergistic Approach ◽  
Key Steps

This account provides an overview of recent work, including our own contribution dealing with Suzuki–Miyaura cross coupling in combination with metathesis (or vice-versa). Several cyclophanes, polycycles, macrocycles, spirocycles, stilbenes, biaryls, and heterocycles have been synthesized by employing a combination of Suzuki cross-coupling and metathesis. Various popular reactions such as Diels–Alder reaction, Claisen rearrangement, cross-metathesis, and cross-enyne metathesis are used. The synergistic combination of these powerful reactions is found to be useful for the construction of complex targets and fulfill synthetic brevity.

Ring-Closing Metathesis Approach to Cage Propellanes Containing Oxepane and Tetrahydrofuran Hybrid System

Synthesis ◽  
2017 ◽  
Vol 49 (24) ◽  
pp. 5339-5350 ◽  
Author(s):  
Sambasivarao Kotha ◽  
Subba Cheekatla ◽  
Darshan Mhatre
Keyword(s):  
Claisen Rearrangement ◽  
Alder Reaction ◽  
Diels Alder ◽  
Ring Closing Metathesis ◽  
Cage Compounds ◽  
Transannular Cyclization ◽  
Diels Alder Reaction ◽  
Grignard Addition ◽  
Key Steps ◽  
First Time

The preparation of a variety of structurally interesting oxygenated cage compounds involving atom-economic processes such as Claisen rearrangement, Diels–Alder reaction, [2+2] photocycloaddition, and ring-closing metathesis (RCM) as key steps is reported. For the first time, oxepane ring system is introduced in cage framework using olefin metathesis as a key step. These cage systems assembled here are difficult to prepare by traditional methods. The synthetic sequence described here opens up new routes to higher order polycycles containing heteroatoms without the involvement of protecting groups. Transannular cyclization observed during Grignard addition and the RCM protocol used here may be applicable to generate unknown oxygenated cage systems.

Synthesis of Modified Phenylalanine Peptides by Cross Enyne Metathesis and a Diels-Alder Reaction as Key Steps

2012 ◽  
Vol 2012 (9) ◽  
pp. 1843-1850 ◽  
Author(s):  
Sambasivarao Kotha ◽  
Deepti Goyal née Bansal ◽  
Niranjan Thota ◽  
Venu Srinivas
Keyword(s):  
Alder Reaction ◽  
Diels Alder ◽  
Enyne Metathesis ◽  
Diels Alder Reaction ◽  
Key Steps

scholarly journals Diversity-Oriented Approaches to Polycycles and Heterocycles via Enyne Metathesis and Diels–Alder Reaction as Key Steps

ACS Omega ◽  
2019 ◽  
Vol 4 (27) ◽  
pp. 22261-22273 ◽  
Author(s):  
Sambasivarao Kotha ◽  
Arjun S. Chavan ◽  
Deepti Goyal
Keyword(s):  
Alder Reaction ◽  
Diels Alder ◽  
Enyne Metathesis ◽  
Diels Alder Reaction ◽  
Key Steps

ChemInform Abstract: Synthesis of Modified Phenylalanine Peptides by Cross Enyne Metathesis and a Diels-Alder Reaction as Key Steps.

ChemInform ◽  
2012 ◽  
Vol 43 (33) ◽  
pp. no-no
Author(s):  
Sambasivarao Kotha ◽  
Deepti Goyal ◽  
Niranjan Thota ◽  
Venu Srinivas
Keyword(s):  
Alder Reaction ◽  
Diels Alder ◽  
Enyne Metathesis ◽  
Diels Alder Reaction ◽  
Key Steps
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