scholarly journals 5-Aminopyrazole as precursor in design and synthesis of fused pyrazoloazines

2018 ◽  
Vol 14 ◽  
pp. 203-242 ◽  
Author(s):  
Ranjana Aggarwal ◽  
Suresh Kumar
Keyword(s):  
Organic Reactions ◽  
Synthetic Methods ◽  
Present Review ◽  
Design And Synthesis ◽  
The World ◽  
Synthetic Routes

The condensation of 5-aminopyrazole with various bielectrophilic moieties results in the formation of pyrazoloazines, an interesting array of fused heterocyclic systems. The development of new synthetic routes towards pyrazoloazines for their biological and medicinal exploration is an attractive area for researchers throughout the world. The present review focuses on various synthetic methods developed in the last decade for the synthesis of differently substituted pyrazoloazines by a broad range of organic reactions by means of 5-aminopyrazole as a precursor.

Synthetic Routes to 2-Iminothiazolidines: State-of-the-Art 2006-2020

2020 ◽  
Vol 24 (24) ◽  
pp. 2823-2844
Author(s):  
Aditya Bhattacharyya
Keyword(s):  
State Of The Art ◽  
Biological Significance ◽  
Review Article ◽  
Synthetic Methods ◽  
Pharmacological Properties ◽  
Cyclic Molecules ◽  
Synthetic Routes

: Multiheteroatom-containing small-sized cyclic molecules such as 2- iminothiazolidines are often found to possess beneficial pharmacological properties. In this review article, the biological significance of 2-iminothiazolidines is discussed and the literature reports published in the last 15 years spanning from 2006 to 2020 describing various preparative routes to access 2-iminothiazolidine derivatives have been categorically and chronologically described. The notable synthetic methods discussed here involve ringexpansion transformations of nonactivated and activated aziridines, thiiranes, epoxides, and other miscellaneous reactions.

Multi-Targeting Anticancer Agents: Rational Approaches, Synthetic Routes and Structure Activity Relationship

2019 ◽  
Vol 19 (7) ◽  
pp. 842-874 ◽  
Author(s):  
Harbinder Singh ◽  
Nihar Kinarivala ◽  
Sahil Sharma
Keyword(s):  
Anticancer Agents ◽  
Cancer Drug ◽  
Design And Synthesis ◽  
Cancer Drug Discovery ◽  
Dual Targeting ◽  
Structure Activity ◽  
Anti Cancer ◽  
Dual Inhibitors ◽  
Recent Trends ◽  
Synthetic Routes

We live in a world with complex diseases such as cancer which cannot be cured with one-compound one-target based therapeutic paradigm. This could be due to the involvement of multiple pathogenic mechanisms. One-compound-various-targets stratagem has become a prevailing research topic in anti-cancer drug discovery. The simultaneous interruption of two or more targets has improved the therapeutic efficacy as compared to the specific targeted based therapy. In this review, six types of dual targeting agents along with some interesting strategies used for their design and synthesis are discussed. Their pharmacology with various types of the molecular interactions within their specific targets has also been described. This assemblage will reveal the recent trends and insights in front of the scientific community working in dual inhibitors and help them in designing the next generation of multi-targeted anti-cancer agents.

scholarly journals Approaches towards the synthesis of 5-aminopyrazoles

2011 ◽  
Vol 7 ◽  
pp. 179-197 ◽  
Author(s):  
Ranjana Aggarwal ◽  
Vinod Kumar ◽  
Rajiv Kumar ◽  
Shiv P Singh
Keyword(s):  
Biological Properties ◽  
Synthetic Methods ◽  
Medicinal Properties ◽  
Synthetic Routes

The biological and medicinal properties of 5-aminopyrazoles have prompted enormous research aimed at developing synthetic routes to these heterocyles. This review focuses on the biological properties associated with this system. Various synthetic methods developed up to 2010 for these compounds are described, particularly those that involve the reactions of β-ketonitriles, malononitrile, alkylidenemalononitriles and their derivatives with hydrazines, as well as some novel miscellaneous methods.

CHALLENGES IN PROVIDING QUALITATIVE LEGAL EDUCATION IN THE CONTEXT OF COVID-19: EXPERIENCE OF RĪGA STRADINS UNIVERSITY

2021 ◽  
Vol 1 ◽  
pp. 742-754
Author(s):  
Andrejs Vilks ◽  
Aldona Kipane
Keyword(s):  
Legal Education ◽  
Synthetic Methods ◽  
Specific Knowledge ◽  
Relevant Study ◽  
Regulatory Frameworks ◽  
The World ◽  
Study Programs ◽  
Potential Impact ◽  
Long Term Impact

The spreading of COVID-19 since March 2020 has had a profound and irreversible impact on all spheres of life around the world. The long-term impact of the pandemic with unpredictable consequences will also be observed in the field of education. The aim of the article is to analyse the potential impact of COVID-19 on the providing of qualitative legal education.  Full-fledged assurance of the qualitative education is linked to common conditions for acquiring of knowledge, skills and competences. There are certain specifics in obtaining legal education, especially higher education. It is related to a combination of circumstances that are relevant to the specific knowledge, skills and competences to be acquired by lawyers and legal assistants. In 2020 a new standard for the legal profession was approved, which not only defines new qualitative requirements for the relevant profession, but also determines the need to make adjustments in the relevant study programs. The process of implementing and performing qualitative legal education in the current circumstances is being transformed in line with the international   and national regulatory frameworks in the context of management of COVID-19. As research methods descriptive, analytical and synthetic methods are used by the authors. 

scholarly journals THE CHARACTER ZHU BAJIE IN “JOURNEY TO THE WEST” BY WU CHENGEN

2019 ◽  
Vol 35 (2) ◽  
Author(s):  
Pham Ngoc Ham
Keyword(s):  
Chinese Literature ◽  
Synthetic Methods ◽  
The West ◽  
Television Production ◽  
The World ◽  
Journey To The West ◽  
Animal Part

“Journey to the West”, one of the Four Great Classical Novels of Chinese literature, was adapted for cinematographic, theatrical and television production, amongst others and spread beyond China’s border, making it familiar to millions of readers and audience in many parts of the world, including Vietnam. On the journey to retrieve original Buddhist scriptures for China, the character Pigsy or Zhu Bajie is portrayed as a half-man, half-pig monster with both good and bad personalities which are represented by the animal part and human part. In the article, the analytical and synthetic methods are used to clarify the meaning and significance of the image of Pigsy or Zhu Bajie in “Journey to the West” by Wu Chengen, and this contributes to teaching ancient Chinese literature to Vietnamese students.

scholarly journals Brain Concussion: New Classifications and Current Physiopathological Knowledge of the Disease

2017 ◽  
Vol 38 (04) ◽  
pp. 284-291
Author(s):  
Daniel Damiani ◽  
Durval Damiani
Keyword(s):  
Review Paper ◽  
Present Review ◽  
Emergency Rooms ◽  
Late Sequelae ◽  
Brain Concussion ◽  
Cerebral Concussion ◽  
High Prevalence ◽  
The World ◽  
New Evidence

AbstractThe present review paper aims to update the definition and classification of cerebral concussion, highlighting its pathophysiological mechanisms. The high prevalence of cerebral concussion in emergency rooms around the world makes it necessary to know its proper management to avoid its late sequelae, which traditionally compromise cognitive aspects of behavior. New evidence on potential neuroprotective treatments is being investigated.

scholarly journals Pyrido[2,3-d]pyrimidin-7(8H)-ones: Synthesis and Biomedical Applications

Molecules ◽  
2019 ◽  
Vol 24 (22) ◽  
pp. 4161 ◽  
Author(s):  
Guillem Jubete ◽  
Raimon Puig de la Bellacasa ◽  
Roger Estrada-Tejedor ◽  
Jordi Teixidó ◽  
José I. Borrell
Keyword(s):  
Biomedical Applications ◽  
Pyridine Ring ◽  
General Structure ◽  
Pyrimidine Ring ◽  
The Body ◽  
Synthetic Methods ◽  
Present Review ◽  
Nitrogen Bases ◽  
Dna And Rna

Pyrido[2,3-d]pyrimidines (1) are a type of privileged heterocyclic scaffolds capable of providing ligands for several receptors in the body. Among such structures, our group and others have been particularly interested in pyrido[2,3-d]pyrimidine-7(8H)-ones (2) due to the similitude with nitrogen bases present in DNA and RNA. Currently there are more than 20,000 structures 2 described which correspond to around 2900 references (half of them being patents). Furthermore, the number of references containing compounds of general structure 2 have increased almost exponentially in the last 10 years. The present review covers the synthetic methods used for the synthesis of pyrido[2,3-d]pyrimidine-7(8H)-ones (2), both starting from a preformed pyrimidine ring or a pyridine ring, and the biomedical applications of such compounds.

scholarly journals Covid-19 and Pregnancy: An Overview

2020 ◽  
Vol 42 (07) ◽  
pp. 420-426
Author(s):  
Pedro Castro ◽  
Ana Paula Matos ◽  
Heron Werner ◽  
Flávia Paiva Lopes ◽  
Gabriele Tonni ◽  
...  
Keyword(s):  
Public Health ◽  
Pregnant Women ◽  
World Health Organization ◽  
Case Series ◽  
Public Health Emergency ◽  
Present Review ◽  
World Health ◽  
The World ◽  
Coronavirus Infection ◽  
Health Organization

AbstractSince the World Health Organization (WHO) declared coronavirus infection (COVID-19) a Public Health Emergency of International Concern in January 2020, there have been many concerns about pregnant women and the possible effects of this emergency with catastrophic outcomes in many countries. Information on COVID-19 and pregnancy are scarce and spread throughout a few case series, with no more than 50 cases in total. The present review provides a brief analysis of COVID-19, pregnancy in the COVID-19 era, and the effects of COVID-19 on pregnancy.

scholarly journals Ecology, Cultivation and Utilization of the Aromatic Greek Oregano (Origanum vulgare L.): A Review

2019 ◽  
Vol 47 (3) ◽  
Author(s):  
Elpiniki SKOUFOGIANNI ◽  
Alexandra D. SOLOMOU ◽  
Nicholaos G. DANALATOS
Keyword(s):  
Essential Oil ◽  
Mediterranean Region ◽  
Present Review ◽  
Digital Object Identifier ◽  
Extensive Literature ◽  
Origanum Vulgare ◽  
Medicinal And Aromatic Plants ◽  
Wide Range ◽  
The World ◽  
The Mediterranean

Medicinal and aromatic plants represent a stable part of the natural biodiversity legacy of many countries in the world. The present review focuses on oregano (Origanum vulgare L.; family Lamiaceae), an endemic herb in Greece that constitutes one of the best known aromatic and medicinal plants originating in the Mediterranean region. In particular, oregano is an evergreen, rich in natural compounds perennial plant that received increased attention in the last years for a wide range of uses. Oregano dry leaves and inflorescences in mixture are used as human and animal food that is extremely rich in antioxidative properties. Additionally, its essential oil is rich in carvacrol, thymol, c-terpinene and p-cymene, and is used for a number of medicinal purposes, e.g. for inhibiting microbial and fungal toxin production as well as for the well-known anti-inflammatory, analgesic, antiarthritic, antiallergic, anticarcinogenic, antidiabetic, cardioprotective, gastroprotective, hepatoprotective, and neuroprotective properties. Due to its perfect quality and high essential oil concentration, Greek oregano (O. vulgare ssp. hirtum) is regarded among the best in the world gaining in popularity in the global markets for food industry applications. Consequently, oregano might be considered as an important low-input, environmental friendly commodity for extensive cultivation in Greece. The present review summarizes on the origin, the morphology, the ecology and the utilization of this plant. Despite the extensive literature available on the use of oregano biomass and essential oil, only few reports exist concerning the cultivation of this plant. Therefore, the present review is additionally focused on the cultivation practices and the importance of cultivation and utilization of Origanum vulgare L. in Greece and generally in the Mediterranean region in the near future, as it constitutes a plant species with high medical, economic and environmental value.   ********* In press - Online First. Article has been peer reviewed, accepted for publication and published online without pagination. It will receive pagination when the issue will be ready for publishing as a complete number (Volume 47, Issue 3, 2019). The article is searchable and citable by Digital Object Identifier (DOI). DOI link will become active after the article will be included in the complete issue. *********

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