scholarly journals Mutagenic activity of quaternary ammonium salt derivatives of carbohydrates

2016 ◽  
Vol 12 ◽  
pp. 1434-1439 ◽  
Author(s):  
Barbara Dmochowska ◽  
Karol Sikora ◽  
Anna Woziwodzka ◽  
Jacek Piosik ◽  
Beata Podgórska
Keyword(s):  
Ammonium Salt ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salt ◽  
Ames Test ◽  
Vibrio Harveyi ◽  
Mutagenic Activity ◽  
Hydrocarbon Chain ◽  
Luminescence Assay ◽  
Derivatives Of ◽  
C Nmr

This paper presents a study on a series of quaternary ammonium salt (QAS) derivatives of glucopyranosides with an elongated hydrophobic hydrocarbon chain. The new N-[6-(β-D-glucopyranosyloxy)hexyl]ammonium bromides and their O-acetyl derivatives were analyzed via 1H and 13C NMR spectroscopy. The mutagenic activity of the newly synthesized QAS was investigated using two different techniques: The Vibrio harveyi luminescence assay and the Ames test. The obtained results support previous findings contesting QAS safety and indicate that QAS, specifically pyridinium derivatives, might be mutagenic.

scholarly journals Quaternary ammonium salt derivatives of allylphenols with peripheral analgesic effect

1991 ◽  
Vol 86 (suppl 2) ◽  
pp. 133-136
Author(s):  
A. B de Oliveira ◽  
T. H. A. Silva ◽  
S. H. Ferreira ◽  
B. B. Lorenzetti
Keyword(s):  
Ammonium Salt ◽  
Quaternary Ammonium ◽  
Analgesic Effect ◽  
Quaternary Ammonium Salt ◽  
Derivatives Of

Synthesis and Preliminary Biological Properties Assessment of Novel 2-S-, 4-, 5-Substituted and Bicyclic Derivatives of 6-Methylpyrimidine-4-ol

2020 ◽  
Vol 17 (2) ◽  
pp. 149-156
Author(s):  
Aleksandr P. Yengoyan ◽  
Zhermen A. Azaryan ◽  
Vergush A. Pivazyan ◽  
Emma A. Ghazaryan ◽  
Rafael A. Tamazyan ◽  
...  
Keyword(s):  
Ammonium Salt ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salt ◽  
Potassium Salt ◽  
Biological Properties ◽  
Subsequent Treatment ◽  
Growth Stimulant ◽  
Derivatives Of

: A series of novel 2-S-, 4-, 5-substituted and bicyclic 6-methylpyrimidine-4-ol derivatives including pyrazole, 1,2,4-triazole and pyridazine moieties in the molecule were synthesized by accessible and efficient methods. Thiopyrazolyl derivatives were obtained from 2-mercapto-6-methylpyrimidin-4-ol. 4-Triazolyl and 4-aminotriazolylpyrimidines were synthesized from the quaternary ammonium salt of pyrimidine and 4-chloro-substituted 2-thiomethyl-6-methylpyrimidine, respectively. The reaction of potassium salt of 1-methyl-6-oxo-1,6-dihydropyridazin-3-ole with ethyl 2-chloro-3-oxobutanoate and subsequent treatment with thiourea led to 6-((4-hydroxy-2-mercapto-6-methylpyrimidin-5-yl)oxy)-2- methylpyridazin-3 (2H)-one. The reaction product of the latter with 3-chloropentan-2,4-dione was subjected to heterocyclization, which afforded the target bicyclic derivative of pyrimidine. The synthesized compounds showed a pronounced stimulating action on plants growth. Their growth stimulant activities were in the range of 60-93% compared to heteroauxin.

Catalyst- and oxidant-free electrochemical para-selective hydroxylation of N-arylamides in batch and continuous-flow

2020 ◽  
Vol 22 (19) ◽  
pp. 6437-6443
Author(s):  
Cheng-Kou Liu ◽  
Meng-Yi Chen ◽  
Xin-Xin Lin ◽  
Zheng Fang ◽  
Kai Guo
Keyword(s):  
Ammonium Salt ◽  
Quaternary Ammonium ◽  
Continuous Flow ◽  
Quaternary Ammonium Salt ◽  
Selective Hydroxylation

A catalyst-, oxidant-, acidic solvent- and quaternary ammonium salt-free electrochemical para-selective hydroxylation of N-arylamides at rt in batch and continuous-flow was developed.

Synthesis and Performance of Polyoxy-ethylene Ester Quaternary Ammonium Salt

2013 ◽  
Vol 50 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Yong-Qiang Sun ◽  
Wen-Jing Li ◽  
Wan-Xu Wang ◽  
Qiu-Xiao Li ◽  
Wieslaw Hreczuch ◽  
...  
Keyword(s):  
Ammonium Salt ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salt ◽  
And Performance

Instability of Solutions of Quaternary Ammonium Permanganates in Dichloromethane

1997 ◽  
Vol 62 (6) ◽  
pp. 849-854 ◽  
Author(s):  
Vladislav Holba ◽  
Renata Košická
Keyword(s):  
Ammonium Salt ◽  
Rate Constants ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salt ◽  
Activation Parameters ◽  
The Stability

The paper deals with instability of solutions of quaternary ammonium permanganates, QMnO4 (Q = tetraethyl-, tetra-1-propyl-, tetra-1-butyl-, tetra-1-pentyl-, tetra-1-octyl-, and cetyltrimethylammonium), in dichloromethane and presents the rate constants and activation parameters of the reduction of permanganate. Attention was paid to the properties of colloidal Mn(IV) intermediate. The stability of the solutions depends markedly on the quaternary ammonium salt used.

Sign in / Sign up

Export Citation Format

Share Document