scholarly journals Total synthesis of panicein A2

2015 ◽  
Vol 11 ◽  
pp. 1991-1996 ◽  
Author(s):  
Lili Yeung ◽  
Lisa I Pilkington ◽  
Melissa M Cadelis ◽  
Brent R Copp ◽  
David Barker
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Cell Lines ◽  
Tumour Cell ◽  
Human Cancer ◽  
In Vitro Cytotoxicity ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Tumour Cell Lines

The first total synthesis of the unusual aromatic sesquiterpene panicein A2 is reported and the structure of the natural product has been confirmed. When tested by the NCI against a range of human cancer cell lines, it was found that panicein A2 exhibits very little antiproliferative activity at 10 μM – an observation that is at odds with the earlier report that stated panicein A2 exhibits in vitro cytotoxicity against a number of tumour cell lines.

scholarly journals Hopane-6α,16α,22-triol: A New Hopane Triterpenoid from the Lichen Parmotrema sancti-angelii

2019 ◽  
Vol 14 (6) ◽  
pp. 1934578X1985820 ◽  
Author(s):  
Jirapast Sichaem ◽  
Huu-Hung Nguyen ◽  
Thuc-Huy Duong
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Spectroscopic Data ◽  
Human Cancer ◽  
In Vitro Cytotoxicity ◽  
Previous Literature ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Ergosterol Peroxide

A new compound, namely hopane-6 α,16 α,22-triol (1), along with 8 known compounds 2 to 9, leucotylin (2), 16 β-acetoxyhopane-6 α,22-diol (3), 6 α-acetoxyhopane-16 β,22-diol (4), zeorin (5), 6 α-acetoxyhopane-22-ol (6), ergosterol peroxide (7), brassicasterol (8), and atranorin (9), was isolated from the lichen Parmotrema sancti-angelii. The structures of all the isolated compounds 1 to 9 were fully characterized using spectroscopic data, as well as comparison with the previous literature data. Moreover, compounds 2 and 4 were assessed for their in vitro cytotoxicity against 3 human cancer cell lines.

scholarly journals A New Non-glucosidic Iridoid from the Roots of Strychnos nux-blanda

2016 ◽  
Vol 11 (6) ◽  
pp. 1934578X1601100 ◽  
Author(s):  
Jirapast Sichaem ◽  
Suttira Khumkratok ◽  
Pongpun Siripong ◽  
Santi Tip-pyang
Keyword(s):  
Physical Properties ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
In Vitro Cytotoxicity ◽  
Previous Literature ◽  
Spectroscopic Methods ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

Strychnuxin (1), a new non-glucosidic iridoid, together with four known compounds, IX (2), loganetin (3), loganin (4) and sweroside (5), were isolated from the roots of Strychnos nux-blanda. The structures of all isolated compounds (1-5) were elucidated through their physical properties and by the use of spectroscopic methods, as well as comparisons with the previous literature. To the best of our knowledge, this is the first isolation of compounds 1-5 from this plant. All isolated compounds were evaluated for their in vitro cytotoxicity against five human cancer cell lines.

In vitro cytotoxicity against different human cancer cell lines of laticifer proteins of Calotropis procera (Ait.) R. Br

2007 ◽  
Vol 21 (8) ◽  
pp. 1563-1573 ◽  
Author(s):  
Jefferson Soares de Oliveira ◽  
Daniel Pereira Bezerra ◽  
Cleverson Diniz Teixeira de Freitas ◽  
José Delano Barreto Marinho Filho ◽  
Manoel Odorico de Moraes ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
In Vitro Cytotoxicity ◽  
Calotropis Procera ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

Synthesis, characterisation and in vitro cytotoxicity of mixed ligand Pt(ii) oxadiazoline complexes with hexamethylenetetramine and 7-nitro-1,3,5-triazaadamantane

2017 ◽  
Vol 46 (36) ◽  
pp. 12226-12238 ◽  
Author(s):  
Stefanie Sieste ◽  
Irina Lifincev ◽  
Nina Stein ◽  
Gabriele Wagner
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
In Vitro Cytotoxicity ◽  
Mixed Ligand ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

The synthesis, spectroscopic and DFT-computational characterisation of trans-Pt(ii) oxadiazoline complexes is described. Some are more cytotoxic in vitro than cisplatin with the human cancer cell lines HeLa and A549.

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