scholarly journals First synthesis of meso-substituted pyrrolo[1,2-a]quinoxalinoporphyrins

2014 ◽  
Vol 10 ◽  
pp. 808-813 ◽  
Author(s):  
Dileep Kumar Singh ◽  
Mahendra Nath
Keyword(s):  
Nitro Group ◽  
Spectral Data ◽  
Aromatic Aldehydes ◽  
Elemental Analyses ◽  
Porphyrin Analogues

A synthetic protocol for the construction of new meso-substituted pyrrolo[1,2-a]quinoxalinoporphyrins is described starting from 5-(4-amino-3-nitrophenyl)-10,15,20-triphenylporphyrin. The reaction of this porphyrin with 2,5-dimethoxytetrahydrofuran, followed by the reduction of the nitro group in the presence of NiCl2/NaBH4 afforded 5-(3-amino-4-(pyrrol-1-yl)phenyl)-10,15,20-triphenylporphyrin. This triphenylporphyrin underwent a Pictet–Spengler cyclization after the reaction with various aromatic aldehydes followed by in situ KMnO4 oxidation to form target porphyrin analogues in good yields. The structures of all synthesized products were established on the basis of spectral data and elemental analyses.

scholarly journals Synthesis and Biological Evaluation of Some New Chalcones Containing 2,5-Dimethylfuran Moiety

2011 ◽  
Vol 8 (2) ◽  
pp. 541-546 ◽  
Author(s):  
S. Sridhar ◽  
S. C. Dinda ◽  
Y. Rajendra Prasad
Keyword(s):  
Aqueous Solution ◽  
Spectral Data ◽  
Potassium Hydroxide ◽  
Room Temperature ◽  
Aromatic Aldehydes ◽  
Biological Evaluation ◽  
Significant Activity ◽  
H Nmr ◽  
Elemental Analyses ◽  
Synthesis And Biological Evaluation

A series of new chalcones(3a-g)were prepared by Claisen-Schmidt condensation of 3-acetyl-2,5-dimethylfuran with various substituted aromatic aldehydes in presence of aqueous solution of potassium hydroxide and ethanol at room temperature. The synthesized chalcones were characterized by means of their IR,1H NMRspectral data and elemental analyses. When these chalcones were evaluated for antimicrobial and anti-inflammatory activities, some of them were found to possess significant activity, when compared to standard drugs.

Synthesis of 2-methyl-3-(5-phenyl or 1,5-diphenyl-2-pyrazolin-3-yl)-1,8-naphthyridines

1988 ◽  
Vol 53 (7) ◽  
pp. 1543-1548 ◽  
Author(s):  
Maringanti Thirumala Chary ◽  
Kaleru Mogilaiah ◽  
Bathula Sreenivasulu
Keyword(s):  
Hydrazine Hydrate ◽  
Spectral Data ◽  
Fungicidal Activity ◽  
Aromatic Aldehydes ◽  
Elemental Analyses

3-Cinnamoyl-2-methyl-1,8-naphthyridines II have been synthesized utilizing Claisen-Schmidt condensation of 3-acetyl-2-methyl-1,8-naphthyridine I with aromatic aldehydes. The cinnamoyl naphthyridines react with hydrazine hydrate and phenylhydrazine to create the corresponding pyrazolinyl 1,8-naphthyridine derivatives (III and IV). The structures II-IV have been confirmed by their elemental analyses and spectral data. Some of the compounds have been screened for their fungicidal activity.

Syntheses and Cytotoxicity Screening of some Novel 1,2,4-Triazine Derivatives against Liver Carcinoma Cell Lines

2020 ◽  
Vol 17 ◽  
Author(s):  
W. Abd El-Fattah
Keyword(s):  
Acetic Anhydride ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Aromatic Aldehydes ◽  
Liver Carcinoma ◽  
Anticancer Activities ◽  
Carcinoma Cell Lines ◽  
Elemental Analyses ◽  
Triazine Derivatives ◽  
C Nmr

: In this work, 1,2,4-triazine derivatives were synthesized and evaluated for anticancer activities. Series of 1,2,4-triazine derivatives (4a, b) were prepared via the reaction of N-benzoyl glycine (1) with aromatic aldehydes in presence of fused sodium acetate and acetic anhydride to give 1,3-oxazolinone derivatives (2a, b), followed by condensation with 1-(ethoxycarbonyl) hydrazine (3) in glacial acetic acid. Compounds (4a, b) then reacted with acetic anhydride, ethyl chloroacetate and 2,4-dinitrophenyl hydrazine yielded the corresponding to N-acetyl derivatives (5a, b), N-(ethoxycarbonyl) methyl derivative (6) and 1,2-disubstituted hydrazine (7), respectively. The structures of the 1,2,4-triazine derivatives were confirmed by IR, 1H, 13C NMR, MS and elemental analyses. Anticancer activity of some 1,2,4-triazine derivatives (4-7) have been investigated. The results revealed that compounds 4a (IC50= 2.7μM), 5a (IC50= 1.5μM), and 5b (IC50= 3.9μM) show promising inhibitory growth efficacy compared to a standard antitumor drug (IC50= 4.6μM). These three compounds can be considered as potential agents against human hepatocellular carcinoma cell lines (HepG-2).

Azaoxa Macrocyclic and Acyclic Complexesof Lanthanides

1998 ◽  
Vol 63 (3) ◽  
pp. 363-370 ◽  
Author(s):  
Violetta Patroniak-Krzyminiewska ◽  
Wanda Radecka-Paryzek
Keyword(s):  
Schiff Base ◽  
Spectral Data ◽  
Macrocyclic Ligand ◽  
Lanthanide Ions ◽  
H Nmr ◽  
Elemental Analyses ◽  
Acyclic Complexes ◽  
Schiff Base Cyclocondensation

The template reactions of 2,6-diacetylpyridine with 3,6-dioxaoctane-1,8-diamine in the presence of dysprosium(III), thulium(III) and lutetium(III) chlorides and erbium(III) perchlorate produce the complexes of 15-membered macrocyclic ligand with an N3O2 set of donor atoms as a result of the [1+1] Schiff base cyclocondensation. In contrast, analogous reactions involving the lighter lanthanide ions (lanthanum(III), samarium(III) and europium(III)) yield the acyclic complexes with terminal acetylpyridyl groupings as products of the partial [2+1] condensation. The complexes were characterized by spectral data (IR, UV-VIS, 1H NMR, MS), and thermogravimetric and elemental analyses.

Synthesis of 4-(3-coumarinyl)-3-benzyl-4-thiazolin-2-one 4-methylbenzylidenehydrazone and determination of the isomeric structure by X-ray analysis

2003 ◽  
Vol 218 (12) ◽  
Author(s):  
Süheyla Özbey ◽  
Nilgün Karalı ◽  
Aysel Gürsoy
Keyword(s):  
Single Crystal ◽  
Diffraction Analysis ◽  
Spectral Data ◽  
X Ray Diffraction ◽  
X Ray ◽  
Isomeric Structure ◽  
Elemental Analyses

AbstractIn this study 4-(3-coumarinyl)-3-benzyl-4-thi azolin-2-one 4-methylbenzylidenehydrazone 3 was synthesised. An independent proof of the thiazolylhydrazone structure of 3 was achieved by single crystal X-ray diffraction analysis. Elemental analyses and spectral data (IR,

scholarly journals Antimicrobial Evaluation and Synthesis of Some Phenylpyrazolo benzothiazolo quinoxaline Derivatives

2009 ◽  
Vol 6 (3) ◽  
pp. 866-870
Author(s):  
CH. Sridevi ◽  
K. Balaji ◽  
A. Naidu ◽  
R. Sudhakaran
Keyword(s):  
Spectral Data ◽  
Aromatic Aldehydes ◽  
Antimicrobial Activities ◽  
Methylene Bridge ◽  
Quinoxaline Derivatives ◽  
Antimicrobial Evaluation

2,3-Diphenyl quinoxaline(SI)was fused with 2-amino benzothiazoles(SII)by a methylene bridge, which was then allowed for acetylation. The acetylated product (SIV) was made to react with different aromatic aldehydes to give chalcones(SV1-SV5). Chalcones refluxed with substituted acid hydrazides to afford different phenyl pyrazolo benzothiazolo quinoxaline derivatives(SVI1-SVI15). The structure of chalcones and phenyl pyrazolo benzothiazolo quinoxaline derivatives were confirmed by M.P, TLC and spectral data. All the synthesized compounds were screened for their antimicrobial activities.

scholarly journals Synthesis and Bio-Spectral Studies of Co(II) Complex of 5-Chloro-2,4-Dihydroxy Butyrophenoneoxime (CDHBOX)

2010 ◽  
Vol 6 (3) ◽  
pp. 1120-1133
Author(s):  
F. Rehman ◽  
M. Bhardwaj ◽  
U.K. Jetley
Keyword(s):  
Spectral Data ◽  
Standard Free Energy ◽  
Spectral Studies ◽  
Curvularia Lunata ◽  
Mass Spectral ◽  
Ir Studies ◽  
Free Energy Of Formation ◽  
Escherchia Coli ◽  
Elemental Analyses ◽  
Point Determination

Co(II) complex of 5-chloro-2,4-dihydroxy butyrophenoneoxime (CDHBOX) was synthesized from 5-chloro-2,4-dihydroxy butyrophenoneoxime by using standard protocol, and characterized by elemental analyses, melting point determination and spectral data. The ML2 (metal/ligand) stoichiometry of the complex was determined by spectrophotometric and potentiometric studies, and mass spectral data. The value of stability constant of the complex was found to be 6.94x 108 while its standard free energy of formation is 12.155 kcal/mol at 27ºC. Beer’s law is obeyed in the concentration range 2-15 ppm of Co. The value of molar extinction coefficient and sensitivity as per Sandell’s scale were found to 3.35x 103 L.mol-1cm-1and 0.017 μg Co/cm2 respectively. The value of activation energy and the Arrhenius constant Arrhenius constant were found as 4.949 kjmol-1, 74.39. The IR studies reveal that the phenolic proton is lost on complexation and the oxygen of the phenolic (–OH) and nitrogen of the oximino (=NOH) groups coordinate with Co(II) ion. The electronic spectra and magnetic susceptibility measurement indicate that the complex is paramagnetic and tetrahedral in nature. The antimicrobial activity of different concentrations of ligand and its Co(II)-complex  has been evaluated against Curvularia lunata, Fusarium oxysporum and Alternaria alternata fungi  and Streproproteus, Staph, Escherchia coli, Klebsella, and pseudomonas bacteria. The results indicated that the ligand (CDHBOX) and its Co(II) complex have good anti-microbial properties. 

scholarly journals THE REACTION BETWEEN 2,2-DIPHENYL-1-PICRYLHYDRAZYL FREE STABLE RADICAL AND N-BROMOSUCCINIMIDE

1998 ◽  
Vol 6 (7) ◽  
pp. 101-106
Author(s):  
Petre Ionita
Keyword(s):  
Nitro Group ◽  
Stable Radical ◽  
Starting Material ◽  
Secondary Product ◽  
Ipso Substitution

The reactions of 2,2-diphenyl-1-picrylhydrazyl (DPPH) or 2,2-diphenyl-1-picrylhidrazine (DPPH-H) with N-bromosuccinimide (NBS) were studied. Two main compounds Br-DPPH and (Br)2 DPPH were obtained, by bromination of the starting material in para-phenyl position, and also a secondary product, N02 DPPH. It was shown that the reactions of NBS with DPPH include a substitution at the picryl group of PPH with liberation in situ of N02 (ipso-substitution of a nitro group with bromine) and subsequently N02 is scavenged by DPPH with the foundation of N02 DPPH.

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