scholarly journals Diversity-oriented synthesis of dihydrobenzoxazepinones by coupling the Ugi multicomponent reaction with a Mitsunobu cyclization

2014 ◽  
Vol 10 ◽  
pp. 209-212 ◽  
Author(s):  
Lisa Moni ◽  
Luca Banfi ◽  
Andrea Basso ◽  
Alice Brambilla ◽  
Renata Riva
Keyword(s):  
Multicomponent Reaction ◽  
Glycolic Acid ◽  
Ugi Reaction ◽  
Diversity Oriented Synthesis ◽  
Simple Protocol ◽  
High Yields

An operationally simple protocol for the synthesis of 2,3-dihydrobenzo[f][1,4]oxazepin-3-ones, based on an Ugi reaction of an ortho-(benzyloxy)benzylamine, glycolic acid, an isocyanide and an aldehyde, followed by an intramolecular Mitsunobu substitution was developed. The required ortho-(benzyloxy)benzylamines have been in situ generated from the corresponding azides, in turn prepared in high yields from salicylic derivatives.

scholarly journals Electrochemical multicomponent synthesis of 4-selanylpyrazoles under catalyst- and chemical-oxidant-free conditions

2021 ◽  
Author(s):  
Yan Wu ◽  
Jin-Yang Chen ◽  
Jing Ning ◽  
Xue Jiang ◽  
Jie Deng ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Raw Materials ◽  
Multicomponent Synthesis ◽  
Mild Conditions ◽  
Simple Protocol ◽  
High Yields

An electrochemical multicomponent reaction was established under catalyst-, chemical-oxidant-free and mild conditions, which provides an eco-friendly and simple protocol for constructing 4-selanylpyrazoles from easily available raw materials with high yields.

Acetic acid mediated regioselective synthesis of 2,4,5-trisubstituted thiazoles by a domino multicomponent reaction

2019 ◽  
Vol 43 (22) ◽  
pp. 8644-8650 ◽  
Author(s):  
Mohit Saroha ◽  
Jitender M. Khurana
Keyword(s):  
Acetic Acid ◽  
Multicomponent Reaction ◽  
Regioselective Synthesis ◽  
Domino Reaction ◽  
Thiazole Derivatives ◽  
Active Methylene

Acetic acid mediated regioselective synthesis of novel 2,4,5-trisubstituted thiazole derivatives has been reported by a domino reaction of thiosemicarbazide and aldehydes/ketones/isatin, to generate thiosemicarbazones (in situ) followed by addition of arylglyoxal and active methylene/activated C–H acids/pyrazole/indole in ethanol at 80 °C.

ChemInform Abstract: Diversity-Oriented Synthesis of Hydrazine-Derived Compounds from Amino Isocyanates Generated in situ.

ChemInform ◽  
2014 ◽  
Vol 45 (18) ◽  
pp. no-no
Author(s):  
Christian Clavette ◽  
Jean-Francois Vincent Rocan ◽  
Andre M. Beauchemin
Keyword(s):  
Diversity Oriented Synthesis

Hypervalent iodine catalysis for selective oxidation of Baylis–Hillman adducts via in situ generation of o-iodoxybenzoic acid (IBX) from 2-iodosobenzoic acid (IBA) in the presence of oxone

2016 ◽  
Vol 40 (12) ◽  
pp. 10300-10304 ◽  
Author(s):  
Raktani Bikshapathi ◽  
Parvathaneni Sai Prathima ◽  
Vaidya Jayathirtha Rao
Keyword(s):  
Selective Oxidation ◽  
Carbonyl Compounds ◽  
Hypervalent Iodine ◽  
In Situ Generation ◽  
Iodosobenzoic Acid ◽  
High Yields

An efficient, eco-friendly protocol for selective oxidation of primary and secondary Baylis–Hillman alcohols to the corresponding carbonyl compounds in high yields has been developed with 2-iodosobenzoic acid (IBA).

A facile approach for the synthesis of 1,3-di- and 1,2,3-tri-substituted indolizines

2015 ◽  
Vol 93 (5) ◽  
pp. 542-545 ◽  
Author(s):  
Jun Tan ◽  
Yiwen Yang ◽  
Jie Chen ◽  
Chunxiang Kuang
Keyword(s):  
Multicomponent Reaction ◽  
Pyridinium Salt ◽  
Quinolinium Salt ◽  
Convenient Synthesis ◽  
High Yields

A convenient synthesis of 1,3-di- and 1,2,3-tri-substituted indolizines involving the multicomponent reaction of pyridinium salt (or quinolinium salt), olefine acid, and 1,2-dichloroethane has been achieved. The process proceeds smoothly in moderate to high yields.

The Acceleration of the Rearrangement of α-Hydroxy Aldimines by Lewis or Brønsted Acids

Synlett ◽  
2018 ◽  
Vol 29 (15) ◽  
pp. 2015-2018 ◽  
Author(s):  
William Wulff ◽  
Xin Zhang ◽  
Yijing Dai
Keyword(s):  
Silica Gel ◽  
Efficient Method ◽  
Bronsted Acids ◽  
High Yields

An efficient method was developed for the synthesis of α-amino ketones from α-hydroxy imines. The reaction occurs through an α-iminol rearrangement involving the migration of a substituent of the carbinol carbon to the imine carbon. The optimal catalysts were found to be silica gel or montmorillonite K 10, which effected migration of a variety of aryl and alkyl substituents in high yields. The rearrangement can also be carried out on imines generated in situ from aldehydes and amines in essentially the same yields as those from the preformed imines.

Enantio- and diastereoselective synthesis of spiropyrazolones via an organocatalytic [1 + 2 + 3] multicomponent reaction

2019 ◽  
Vol 17 (41) ◽  
pp. 9217-9225 ◽  
Author(s):  
Yan-Ling Ji ◽  
He-Ping Li ◽  
Yue-Yan Ai ◽  
Guo Li ◽  
Xiang-Hong He ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Diastereoselective Synthesis ◽  
Asymmetric Catalytic ◽  
High Yields

An asymmetric catalytic [1 + 2 + 3] multicomponent reaction of malononitrile, benzaldehyde and α-arylidene pyrazolinones to produce spiropyrazolones in high yields, with excellent enantioselectivities and good diastereoselectivities.

Geological and Gas-Content Features of Coalbed Methane System in Qinshui Basin, Shanxi

2012 ◽  
Vol 170-173 ◽  
pp. 1187-1191
Author(s):  
Ya Hui Jia ◽  
Xiao Ping Xie ◽  
Ai Li Lu
Keyword(s):  
Coalbed Methane ◽  
Gas Content ◽  
Structural Deformation ◽  
Shanxi Province ◽  
Qinshui Basin ◽  
The North ◽  
North Part ◽  
Coalbed Methane Reservoir ◽  
High Yields

Colabed methane system is a natural system that consists of coal seams, coalbed methane in them and surrounding rocks. As an unconventional natural gas, reservoir and conservation of coalbed methane are different from those of conventional hydrocarbon. The Qinshui Basin, covering an area about 30,000sq.km in southeastern Shanxi Province, has abundant coalbed methane resources in the carboniferous Taiyuan formation and permian Shanxi formation, with an in-situ methane resource 3.3×1012 m3.In this study, the structural deformation and tectonic evolution of coalbed methane system in Qinshui basin were reported. Relationships between structural deformation and the formation of coalbed methane reservoir in Qinshui Basin were also discussed. The results show that Yangquan-Shouyang area in the north part of the basin and Tunliu-Xiangyuan area in the east are favorable for formation coalbed methane system. In contrast, Jincheng-Qinshui area in the south part of basin and the Qinyuan area in the middle of basin are favorable for both the formation of coalbed methane reservoirs and high yields as well.

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