scholarly journals Heyde’s syndrome: An enigma

2021 ◽  
Vol 33 (1) ◽  
pp. 95-100
Author(s):  
Fayaz Mohammed Khazi ◽  
Nayyer R Siddiqi ◽  
Yehia Mohamed Karaly ◽  
Obaid Aljassim ◽  
Zohair Y Al-Halees
Keyword(s):  
Heyde’S Syndrome

scholarly journals JUST ANOTHER BLEEDING HEART: HEYDE'S SYNDROME TREATED WITH TAVR

2021 ◽  
Vol 77 (18) ◽  
pp. 2377
Author(s):  
Travis Benzing ◽  
Michael Grzeskowiak ◽  
Mark Gajjar ◽  
William Kessler ◽  
Mark Pirwitz ◽  
...  
Keyword(s):  
Heyde’S Syndrome

scholarly journals Heyde's Syndrome Incidence and Outcome in Patients Undergoing Transcatheter Aortic Valve Implantation

2013 ◽  
Vol 61 (6) ◽  
pp. 687-689 ◽  
Author(s):  
Cosmo Godino ◽  
Ludovica Lauretta ◽  
Anna Giulia Pavon ◽  
Antonio Mangieri ◽  
Giacomo Viani ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Transcatheter Aortic Valve Implantation ◽  
Transcatheter Aortic Valve ◽  
Aortic Valve Implantation ◽  
Heyde’S Syndrome ◽  
Valve Implantation

Perspectives on Heyde's Syndrome and Calcific Aortic Valve Disease

2021 ◽  
pp. 100930
Author(s):  
Ramy Abdelmaseih ◽  
Ravi Thakker ◽  
Randa Abdelmasih ◽  
Arroj Ali ◽  
Mustajab Hasan
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Disease ◽  
Valve Disease ◽  
Calcific Aortic Valve Disease ◽  
Heyde’S Syndrome

scholarly journals Gastrointestinal Bleeding due to Angiodysplasia in a Patient with Severe Aortic Stenosis: Heyde’s Syndrome

2013 ◽  
Vol 21 (3) ◽  
pp. 288-290 ◽  
Author(s):  
Felipe Homem Valle ◽  
Fernando Pivatto Júnior ◽  
Luiz Carlos Corsetti Bergoli ◽  
Rodrigo Vugman Wainstein ◽  
Marco Vugman Wainstein
Keyword(s):  
Aortic Stenosis ◽  
Gastrointestinal Bleeding ◽  
Severe Aortic Stenosis ◽  
Heyde’S Syndrome

Report of a Case of Heyde's Syndrome Diagnosed by Abnormal Closure Times Despite Normal Von Willebrand's Activity

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 1403-1403
Author(s):  
Pernilla D'Souza ◽  
Mark Blostein
Keyword(s):  
Aortic Valve ◽  
Aortic Stenosis ◽  
Gastrointestinal Bleeding ◽  
High Shear ◽  
Life Threatening ◽  
Cofactor Activity ◽  
Heyde’S Syndrome ◽  
Von Willebrand ◽  
Ristocetin Cofactor ◽  
Ristocetin Cofactor Activity

Abstract Abstract 1403 In 1958, EC Heyde described a syndrome of iron deficiency anemia due to gastrointestinal bleeding (GI) in a patient with calcific aortic stenosis. In 1992, Warkentin et al. hypothesized a bleeding diathesis due to a link between Heyde's Syndrome and acquired Von Willebrand Syndrome. This bleeding syndrome has now been shown to result from the loss of the largest multimers of von Willebrand Factor (VWF) and is therefore classified as acquired Type 2A Von Willebrand Syndrome. Hypotheses suggest that the high shear stresses that are obtained in tortuous angiodysplastic lesions work with this deficiency of VWF, to produce gastrointestinal bleeding that is notoriously difficult to elucidate on endoscopy. It has been shown repeatedly that replacement of a stenotic aortic valve results in cessation of bleeding. Here we present a case of Heyde's Syndrome diagnosed with abnormal Closure Times and normal VWF Ristocetin cofactor activity. In this case, a 79-year-old man with known aortic stenosis and several episodes of GI bleeding was cured of a life threatening hemorrhage after the replacement of his stenotic aortic valve. At the time of his first notable gastrointestinal bleed, a tagged RBC scan showed a source of hemorrhage in the small bowel. Subsequently, two video capsule endoscopies showed jejunal angiodysplasia. After recurrent bleeding episodes, this patient presented with a life-threatening GI hemorrhage, which, in the context of aortic stenosis, raised the suspicion for Heyde's Syndrome. At this time, he presented with hematochezia requiring massive transfusions, and admission to the Intensive Care Unit. A tagged RBC scan showed active bleeding in a location that matched previous scans. The following tests were within normal limits: Factor VIII (1.53), VWF Ag (1.26), VWF:Rco activity (1.11), and the ratio of VWF Ag/VWF:Rco (0.88). However, the Dade Behring PFA-100 platelet function analyzer demonstrated that Closure Times with collagen/adenosine (> 300 sec) and with collagen/epinephrine (> 300 sec) were prolonged. In the clinical context consistent with Heyde's Syndrome, the patient's native aortic valve was replaced with a 21mm Carpentier-Edwards Magna Ease Bovine valve. As is classic for this syndrome, the valve replacement was curative. Since the surgery, the patient has not required further transfusions or interventions for gastrointestinal hemorrhage. In this case, our observations are consistent with previous reports by Warkentin et al. and Vincentellli et al. What is unique about our current report is that we measured both Ristocetin cofactor activity and Closure Times, two commonly available assays in most coagulation laboratories. Ristocetin cofactor activity is the current gold standard for measuring platelet function activity but may miss activities under high shear stress. The Closure Time, on the other hand, is able to detect defects in platelet aggregation under such conditions and may be the only manner by which such abnormalities in VWF function are detected. Therefore, we conclude that Closure Times should be used to screen for acquired Von Willebrand's Syndrome in Heyde's Syndrome. Disclosures: No relevant conflicts of interest to declare.

scholarly journals 0353: Impact of TAVI on primary hemostasis, von Willebrand factor and Heyde’s syndrome: a prospective monocenter study

2015 ◽  
Vol 7 (1) ◽  
pp. 53
Author(s):  
Thibault Caspar ◽  
Laurence Jesel ◽  
Dominique Desprez ◽  
Lélia Grunebaum ◽  
Hafida Samet ◽  
...  
Keyword(s):  
Von Willebrand Factor ◽  
Primary Hemostasis ◽  
Heyde’S Syndrome ◽  
Von Willebrand ◽  
Willebrand Factor

scholarly journals Long Survival after Gastrointestinal Bleeding in a New-Onset Heyde’s Syndrome Patient Treated with Multiple Endoscopic Hemostatic Procedures and Repeated Transfusions after Aortic Valve Replacement

2021 ◽  
pp. 819-824
Author(s):  
Genso Notoya ◽  
Ryota Niikura ◽  
Atsuo Yamada ◽  
Masanori Ochi ◽  
Takashi Kawai ◽  
...  
Keyword(s):  
Gastrointestinal Bleeding ◽  
Sigmoid Colon ◽  
Valve Replacement ◽  
Mechanical Valve ◽  
Factor Deficiency ◽  
Old Japanese ◽  
Heyde’S Syndrome ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
New Onset

Heyde’s syndrome, which is caused by aortic stenosis and subsequent acquired von Willebrand factor deficiency, is a gastrointestinal bleeding disease. Gastrointestinal bleeding develops in patients with Heyde’s syndrome, which may have a different prognosis from general gastrointestinal bleeding; thus, it is important to understand the clinical course. We report a 76-year-old Japanese female who underwent aortic mechanical valve replacement 1 year ago and presented with recurrent gastrointestinal bleeding in angiodysplasia of the sigmoid colon. Endoscopic interventions achieved hemostasis. However, 6 rebleeding events occurred due to a sigmoid colon ulcer and gastric and jejunal angiodysplasia 7 years after first hemostasis. The patient underwent multiple endoscopic hemostatic procedures (upper, lower, and balloon-assisted endoscopy) and repeated transfusions (total of 394 units of red blood cells). The intensive treatment contributed to the survival time of 10 years. In addition, we performed a literature review of the prognosis of patients with Heyde’s syndrome.

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