scholarly journals One-year temporal stability of delay-discount rates

2009 ◽  
Vol 16 (3) ◽  
pp. 457-462 ◽  
Author(s):  
Kris N. Kirby
2005 ◽  
Vol 15 (3) ◽  
pp. 213-222 ◽  
Author(s):  
Kris N. Kirby ◽  
Gordon C. Winston ◽  
Mariana Santiesteban

2002 ◽  
Vol 39 (2) ◽  
pp. 124-132 ◽  
Author(s):  
Anne M. Schell ◽  
Michael E. Dawson ◽  
Keith H. Nuechterlein ◽  
Kenneth L. Subotnik ◽  
Joseph Ventura

2020 ◽  
pp. 001112872092254
Author(s):  
David Hatten ◽  
Eric L. Piza

This study investigates the temporal stability of identified near-repeat robbery patterns in Newark, New Jersey. With one noteworthy exception, scholars have yet to explore the temporal stability of identified spatiotemporal crime clusters. Furthermore, researchers have yet to measure the near-repeat phenomenon longitudinally. To fill this gap, this study employs a longitudinal design to measure variation in effect size and significance of identified near-repeat crime patterns across 13 “rolling” one-year time periods within a 2-year study period (January 2015–December 2016). Temporal instability was found within two out of six spatiotemporal crime clusters. Results are reported in the form of formalized descriptive statistics and visualizations of temporal trends.


2008 ◽  
Vol 51 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Paulo de Souza Gonçalves ◽  
Mário Luiz Teixeira de Moraes ◽  
Lígia Regina Lima Gouvêa ◽  
Adriano Tosoni da Eira Aguiar ◽  
Erivaldo José Scallopi Júnior

The objective of this study was to assess genotype-year interaction and determine temporal stable genotypes across six years of rubber yield evaluation. Stability analyses were performed by Eberhart and Russell method for rubber yield. Twenty-five genotypes were analyzed in a randomized complete block design with three replications. The best genotype in one year was not same always in the other year. The genotype components were partitioned into linear (genotypes within year) and nonlinear (pooled deviations) components. Significant mean square for linear components was predictable. This indicated that the performance of genotypes across the years for rubber yield could be predicted. Among the analyzed genotypes the IAC 40 also was considered highly productive and vigorous, with suitable adaptation.


2002 ◽  
Vol 23 (3) ◽  
pp. 291-316 ◽  
Author(s):  
Kris N Kirby ◽  
Ricardo Godoy ◽  
Victoria Reyes-Garcı́a ◽  
Elizabeth Byron ◽  
Lilian Apaza ◽  
...  

2014 ◽  
Vol 32 (3_suppl) ◽  
pp. 16-16 ◽  
Author(s):  
Todd A. Hembrough ◽  
Wei-Li Liao ◽  
Sheeno Thyparambil ◽  
Les Henderson ◽  
Brittany Rambo ◽  
...  

16 Background: Overexpression of MET in gastroesophageal cancer (GEC) is associated with poor prognosis and potentially predictive of anti-MET therapeutic benefit. IHC has been the method chosen to quantify MET expression to date. However, IHC is semi-quantitative, suffers from cross-reactivity, and is low throughput. Moreover, MET IHC is hampered by antigenic instability in FFPE sections, limiting its utility to recently cut FFPE sections. Increasing recognition of the importance of other biomarkers in GEC suggests that ‘economic’ testing of scarce samples will be required. We sought to develop a MET quantitative assay within our ‘GEC-plex’ Liquid-Tissue-selected reaction monitoring (LT-SRM) MS test. Methods: We used trypsin digestion mapping of rMET to identify unique peptides for MS assay development. The assay was pre-clinically validated in 5 cell lines, where electrochemiluminescence (ECL) immunoassay measurement of MET was also performed. To assess the MET MS assay stability from archival FFPE sections, freshly cut FFPE tissue sections were immediately microdissected, processed and analyzed, while adjacent sections were processed and analyzed one year after cutting, to compare temporal quantification from the same FFPE samples (n=33). MET expression was assessed in GEC cases (n=121), and compared to IHC and FISH in select cases. Results: Tryptic digestion mapping of rMET showed that peptide TEFTTALQR was optimal for MET quantification. The LLOD for this peptide was 150 amol with CV<20%. Validation of the MET MS assay on 5 cell lines revealed concordance when compared to ECL (R2=0.99). The MET MS assay demonstrated temporal stability of serial sections cut from 33 samples analyzed one year apart: CVs<20%, R2=0.75. Analysis of 121 GEC FFPE tissues showed a broad range of MET expression levels (<150-4600 amol/ug), with 36/121 (29.7%) having detectable levels, similar to that observed using IHC. MS expression thresholds were determined that reliably identified MET gene amplification; sensitivity and specificity of these thresholds will be presented. Conclusions: ‘GEC-plex’ has a quantitative, sensitive, and specific MET MS assay that can be multiplexed along with other GEC biomarkers.


2014 ◽  
Vol 2 ◽  
Author(s):  
Shinichi Sunagawa ◽  
Siegfried Schloissnig ◽  
Manimozhiyan Arumugam ◽  
Kristoffer Forslund ◽  
Makedonka Mitreva ◽  
...  

Introduction: The breakthrough of next generation sequencing-technologies has enabled large-scale studies of natural microbial communities and the 16S rRNA genes have been widely used as a phylogenetic marker to study community structure. However, major limitations of this approach are that neither strain-level resolution nor genomic context of microorganisms can be provided. This information, however, is crucial to answer fundamental questions about the temporal stability and distinctiveness of natural microbial communities.Material and methods: We developed a methodological framework for metagenomic single nucleotide polymorphism (SNP) variation analysis and applied it to publicly available data from 252 human fecal samples from 207 European and North American individuals. We further analyzed samples from 43 healthy subjects that were sampled at least twice over time intervals of up to one year and measured population similarities of dominant gut species.Results: We detected 10.3 million SNPs in 101 species, which nearly amounts to the number identified in more than 1,000 humans.Conclusion: The most striking result was that host-specific strains appear to be retained over long time periods. This indicates that individual-specific strains are not easily exchanged with the environment and furthermore, that an individuals appear to have a unique metagenomic genotype. This, in turn, is linked to implications for human gut physiology, such as the stability of antibiotic resistance potential.


2022 ◽  
Vol 38 (1) ◽  
pp. 101-109
Author(s):  
Almudena Giménez de la Peña ◽  
Miguel López-Zamora ◽  
Oscar Vila ◽  
Auxiliadora Sánchez ◽  
Lisa B. Thorell

Background: The Childhood Executive Functioning Inventory (CHEXI) was designed to identify EF deficits in daily life contexts. The aim of the present study was to validate the Spanish version of the CHEXI in 4-5-year-old children. Method: Parents’ ratings of the CHEXI and laboratory tests of EF were investigated in two large samples of 445 children aged 4 years (196 girls, 249 boys) and 459 children aged 5 years (208 girls, 251 boys). CHEXI ratings were collected again after one-year. Results: The two-factor structure of the CHEXI (i.e., Working Memory and Inhibition) was replicated, showing high internal consistency and temporal stability. The 4-year-olds were reported to have higher EF deficits than 5-year-olds have. Boys were rated as having higher EF deficits than girls were. However, gender differences were not significant contrasting performance on EF tasks. Finally, associations between CHEXI ratings and EF tests were weak, suggesting that EF tests and EF ratings capture different aspects of EF. Conclusions: The Spanish CHEXI provides a suitable instrument to assess EF in 4-5-year-old children. Contexto: El Childhood Executive Functioning Inventory (CHEXI) se diseñó para detectar déficit de Funciones Ejecutivas (FE) en contextos de la vida diaria. El propósito del presente estudio era validar la versión española del CHEXI para niños de 4 y 5 años. Método: Se obtuvieron las valoraciones de los padres y las puntuaciones en test de laboratorio en una muestra de 445 niños de 4 años (196 niñas, 249niños) y otra de 459 niños de 5 años (208 niñas, 251 niños). Un año más tarde se volvieron a recoger las valoraciones de los padres en CHEXI. Resultados: Se replicó la estructura de dos factores de CHEXI (Memoria de Trabajo e Inhibición), obteniendo una alta consistencia interna y estabilidad temporal. Los niños de 4 años eran valorados con mayor déficit en FE que los niños de 5 años. Los niños alcanzaban puntuaciones más elevadas de déficit de FE. Sin embargo, no aparecieron diferencias significativas de género en las pruebas conductuales. Finalmente, se encontró una baja asociación entre las valoraciones de CHEXI y las puntuaciones de las pruebas conductuales. Este resultado sugiere que los inventarios y las medidas conductuales evalúan diferentes aspectos de las FE. Conclusiones: La versión española de CHEXI ofrece un instrumento válido para evaluar las FE en niños de 4 y 5 años.


Itinerario ◽  
2000 ◽  
Vol 24 (2) ◽  
pp. 146-169 ◽  
Author(s):  
Michael Leroy Oberg

In August of 1587 Manteo, an Indian from Croatoan Island, joined a group of English settlers in an attack on the native village of Dasemunkepeuc, located on the coast of present-day North Carolina. These colonists, amongst whom Manteo lived, had landed on Roanoke Island less than a month before, dumped there by a pilot more interested in hunting Spanish prize ships than in carrying colonists to their intended place of settlement along the Chesapeake Bay. The colonists had hoped to re-establish peaceful relations with area natives, and for that reason they relied upon Manteo to act as an interpreter, broker, and intercultural diplomat. The legacy of Anglo-Indian bitterness remaining from Ralph Lane's military settlement, however, which had hastily abandoned the island one year before, was too great for Manteo to overcome. The settlers found themselves that summer in the midst of hostile Indians.


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