scholarly journals The average rate of change for continuous time models

2009 ◽  
Vol 41 (2) ◽  
pp. 268-278 ◽  
Author(s):  
Ken Kelley
Genetics ◽  
1976 ◽  
Vol 83 (3) ◽  
pp. 583-600
Author(s):  
Thomas Nagylaki

ABSTRACT Assuming age-independent fertilities and mortalities and random mating, continuous-time models for a monoecious population are investigated for weak selection. A single locus with multiple alleles and two alleles at each of two loci are considered. A slow-selection analysis of diallelic and multiallelic two-locus models with discrete nonoverlapping generations is also presented. The selective differences may be functions of genotypic frequencies, but their rate of change due to their explicit dependence on time (if any) must be at most of the second order in s, (i.e., O(s  2)), where s is the intensity of natural selection. Then, after several generations have elapsed, in the continuous time models the time-derivative of the deviations from Hardy-Weinberg proportions is of O(s  2), and in the two-locus models the rate of change of the linkage disequilibrium is of O(s  2). It follows that, if the rate of change of the genotypic fitnesses is smaller than second order in s (i.e., o(s  2)), then to O(s  2) the rate of change of the mean fitness of the population is equal to the genic variance. For a fixed value of s, however, no matter how small, the genic variance may occasionally be smaller in absolute value than the (possibly negative) lower order terms in the change in fitness, and hence the mean fitness may decrease. This happens if the allelic frequencies are changing extremely slowly, and hence occurs often very close to equilibrium. Some new expressions are derived for the change in mean fitness. It is shown that, with an error of O(s), the genotypic frequencies evolve as if the population were in Hardy-Weinberg proportions and linkage equilibrium. Thus, at least for the deterministic behavior of one and two loci, deviations from random combination appear to have very little evolutionary significance.


2021 ◽  
Vol 11 (11) ◽  
pp. 5072
Author(s):  
Byung-Kook Koo ◽  
Ji-Won Baek ◽  
Kyung-Yong Chung

Traffic accidents are emerging as a serious social problem in modern society but if the severity of an accident is quickly grasped, countermeasures can be organized efficiently. To solve this problem, the method proposed in this paper derives the MDG (Mean Decrease Gini) coefficient between variables to assess the severity of traffic accidents. Single models are designed to use coefficient, independent variables to determine and predict accident severity. The generated single models are fused using a weighted-voting-based bagging method ensemble to consider various characteristics and avoid overfitting. The variables used for predicting accidents are classified as dependent or independent and the variables that affect the severity of traffic accidents are predicted using the characteristics of causal relationships. Independent variables are classified as categorical and numerical variables. For this reason, a problem arises when the variation among dependent variables is imbalanced. Therefore, a harmonic average is applied to the weights to maintain the variables’ balance and determine the average rate of change. Through this, it is possible to establish objective criteria for determining the severity of traffic accidents, thereby improving reliability.


PAMM ◽  
2007 ◽  
Vol 7 (1) ◽  
pp. 1022903-1022904
Author(s):  
Youdong Lin ◽  
Mark A. Stadtherr

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